Clinical trials: Cognition Disorders in Old Age, open to volunteers
Depression - Major Depressive Disorder, Cognition Disorders in Old Age
Real-world Clinical Response to Trazodone in Italy, Poland, and Romania
TRACOMDD study is a study with the intention to describe the real-world use of trazodone and the clinical response in a sub-group of patients affected by Major Depressive Disorder and Mild Cognitive impairment, by collecting data…
- Trial name
- NCT07377682
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Cognitive Dysfunction, Mobility Limitation
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain…
- Conditions
- Cognitive Dysfunction, Mobility Limitation, Frail Elderly
- Trial name
- NCT05830942
- Testing
- Walking Exercise, Prefrontal Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Eldery People, Cognitive Decline
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and…
- Conditions
- Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
- Trial name
- NCT06933095
- Testing
- LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Cincinnati
Aging, Balance Control in Elderly
Effects of Telerehabilitation-Based Dual-Task Exercises on Balance, Fall Risk, Cognitive Function, and Sleep Quality in Geriatric Individuals
The purpose of this study is to investigate the effects of dual-task exercises-which simultaneously target cognitive and motor functions-delivered via telerehabilitation on fall risk, balance, cognitive functions, and sleep…
- Conditions
- Aging, Balance Control in Elderly, Sleep Disorder (Disorder)
- Trial name
- NCT07472101
- Testing
- Telerehabilitation Based Dual-Task Exercises, Educational Brochure and Phone Follow-Up
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Mild Cognitive Impairment, Mild Dementia
Sensory Enrichment Using Aromatherapy for Neurobehavioral and Psychological Symptoms in Early Dementia
To determine if diffusion aromatherapy exposure to an essential oil blend can potentially improve mild cognitive impairment/mild dementia symptoms and relieve caregiver stress.
- Trial name
- SENSE (NCT07234357)
- Testing
- No Intervention, Aromatherapy
- Where
- 2 sites in Singapore
- Volunteers
- 200 people
- Sponsor
- National Cancer Centre, Singapore
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Cognitive Intervention, Mild Cognitive Impairment
Cognitive Intervention for Cognitive Impairment
Mild cognitive impairment is characterized by cognitive dysfunction without impairment in instrumental activities of daily living, with aging being the primary risk factor.
- Conditions
- Cognitive Intervention, Mild Cognitive Impairment, Elderly Adults, Diabetes Mellitus
- Trial name
- NCT07747675
- Testing
- cognitive intervention
- Volunteers
- 102 people
- Sponsor
- Instituto Mexicano del Seguro Social
Mild Cognitive Impairment (MCI)
Effects of Tadalafil on Cognition and Cerebral Hemodynamics in Elderly Patients With Mild Cognitive Impairment
The goal of this clinical trial is to determine if taking four weeks of a daily low dose of tadalafil is possible and safe in elderly males and females with mild cognitive impairment.
- Trial name
- NCT07882901
- Testing
- Tadalafil 5 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Los Angeles Brain Science Project
Cognitive Decline, Aging
Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults
This prospective observational study aims to investigate the effects of a multidomain community-based support program on cognitive function and quality of life in older adults attending the Vefahane Life Center in Istanbul…
- Conditions
- Cognitive Decline, Aging, Quality of Life
- Trial name
- NCT07610109
- Testing
- Multidomain Community Support Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Cognition Disorders in Old Age, Cognitive and Behavioral Impairment
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive…
- Trial name
- NCT07338682
- Testing
- L-Arginine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Geriatric, Elderly
Validity and Reliability of the Turkish Form of the Enjoyment of Physical Activity Scale-8 in Geriatrics With Minimal Cognitive Impairment
The main objective of this study is to examine the validity and reliability of the Turkish form of the Enjoyment of Physical Activity Scale-8 (PACES-8) in individuals aged 65 and over with Minimal Cognitive Impairment (MCI).
- Conditions
- Geriatric, Elderly, Cognitive Abnormality
- Trial name
- NCT07588685
- Testing
- Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Cognitive Impairment, Cognitive Impairment, Mild
Comparative Evaluation of Immediate vs Progressive Standing Dual Task Training in Elderly With Mild and Moderate Cognitive Impairment
older adults with mild and moderate cognitive impairment. compare immediate vs progressive standing dual-task training. assess balance, cognition, executive function, mobility, and quality of life.
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Moderate Cognitive Impairment
- Trial name
- NCT07764250
- Testing
- Immediate standing dual task training, progressive standing dual task training
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Shifa Tameer-e-Millat University
Cognitive Impairment, Balance Changes
LSVT Big and Dual Task Training in Cognitive Impaired Patients
The goal of this study ifs to determine the comparative effects of Lee Silverman voice treatment Big and dual task training on balance, cognition and functional mobility in older adults with cognitive impairment.
- Conditions
- Cognitive Impairment, Balance Changes, Cognition Disorders in Old Age, Functional Mobility
- Trial name
- NCT06927362
- Testing
- Lee Silverman treatment big, Dual task training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Ageing, Disability
The Beijing Longitudinal Disability Survey in Community Elderly
The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for…
- Conditions
- Ageing, Disability, Cognitive Impairment, Frailty
- Trial name
- BLINDSCE (NCT06863727)
- Where
- China
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Dementia, Cognitive Dysfunction ( MMSE < 24 )
Animal-Assisted Therapy Combined With Standard Rehabilitation for Motor Recovery in Dementia Patients in a Medical and Rehabilitation Care Unit
The goal of this randomized study is to find out if animal-assisted therapy (AAT) - a structured program where trained animals take part in care sessions guided by health professionals - can help improve movement abilities in…
- Conditions
- Dementia, Cognitive Dysfunction ( MMSE < 24 ), Motor Skills Disorders
- Trial name
- RéMédi - A (NCT07730983)
- Testing
- Animal-Assisted Therapy, Standard psychomotor rehabilitation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- LNA SANTE
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Bipolar Disorder, Cognitive Impairment
Cognitive Stimulation for Elderly Bipolar Patients
Age is a major risk factor for the development of cognitive disorders and neurodegenerative pathologies. Cognitive disorders during the phases of bipolar disease are known to exist, and alterations increase significantly after…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Age-related Cognitive Decline
- Trial name
- TONIC (NCT04184375)
- Testing
- cognitive stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Gastric Cancer, Gastric Adenocarcinoma
Frailty, Immunonutrition, Surgery Type, and Biologic Recovery in Elderly Gastric Cancer
This prospective observational cohort study will evaluate the effects of multidimensional frailty phenotypes, immunonutritional status, and surgical approach on biological recovery in patients aged 60 years and older undergoing…
- Trial name
- NCT07803159
- Testing
- Laparoscopic Gastrectomy, Open Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 328 people
- Sponsor
- Kocaeli City Hospital