Clinical trials: Cognitive/Functional Effects
Mild Cognitive Impairment
Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic…
- Trial name
- NCT02082418
- Testing
- Alpha-lactalbumin, Whey, Casein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cardiometabolic Health, Gastro-intestinal Wellbeing
Effects of Wholegrains on Children's Health (KORN)
KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.
- Conditions
- Cardiometabolic Health, Gastro-intestinal Wellbeing, Cognitive Function, Overweight
- Trial name
- NCT04430465
- Testing
- Grain products high in wholegrains from oat and rye, Grain products low in wholegrains
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Subjective Memory Impairment
Effect of Krill Oil on Cognitive Function in Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Krill oil on cognitive function in adults with subjective memory impairment for 12 weeks.
- Trial name
- NCT04347421
- Testing
- Krill oil group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Alteration of Cognitive Function, Disturbance in Affect (Finding)
Investigating the Effect of Dietary Supplement VSL#3 on Cognition and Mood in Healthy Older Adults
This research aims to determine whether a 12 week daily dose of VSL#3 has any measurable effects on memory, attention, executive function or self-reported mood and anxiety in healthy older adults.
- Trial name
- NCT01877967
- Testing
- VSL#3
- Where
- Ireland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Aging, Age-related Cognitive Decline
Acute Raspberry Intake on Metabolic Control and Cognitive Function
The purpose of this project is to determine whether restoring the post-prandial metabolic/inflammatory balance via supplementation with raspberries results in improved cognitive performance, and if these enhancements are mediated…
- Conditions
- Aging, Age-related Cognitive Decline, Obesity
- Trial name
- NCT03743792
- Testing
- Active breakfast, Control breakfast
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA Human Nutrition Research Center on Aging
Neurocognitive Function
Comparison of the Effects of Ciprofol and Propofol on Cognitive Function After Painless Gastroenteroscopy
This randomized platform trial compared ciprofol and propofol for early neurocognitive recovery in adults undergoing painless gastrointestinal endoscopy.
- Trial name
- NCT07887594
- Testing
- Ciprofol
- Where
- China
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Mild Cognitive Impairment (MCI)
Comparison of Different Training Programs on Cognitive Function
The goal of the project is to identify the most effective exercise modalities in terms of neuroprotective effects and FP improvement.
- Trial name
- NCT06682741
- Testing
- Exercise
- Where
- Poland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Schizophrenia
Clinical Trial of Tolcapone for Cognition in Schizophrenia
This study will evaluate whether Tolcapone improves cognition in healthy volunteers as well as patients with schizophrenia. Talcapone is a drug that has been FDA approved for Attention Deficit Disorder and allegedly increase the…
- Trial name
- NCT00044083
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognitive Function
Pain Effect on Attention Using an Ipad Game App
Cognitive performance will be studied over time using an iPad game interface called the nine choice human game (5CH) in normal volunteer subjects before during and after experimentally induced thermal (cold or warm) pain or…
- Trial name
- NCT03115788
- Testing
- Heat induced pain, Cold Induced Pain, iPad
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Old Age; Debility, Psychological Distress
Mindfulness-based Short Intervention for Seniors - Decentering Effects on Cognitive Functions and Psychological Distress
The present study examined the effect of a short Mindfulness-based intervention emphasizing a 'decentering' component on elderly seniors.
- Conditions
- Old Age; Debility, Psychological Distress, Cognitive Change
- Trial name
- NCT04165005
- Testing
- decentering, guided imagery
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ben-Gurion University of the Negev
Healthy
Effects of Dietary Interventions on the Aging Brain
The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00996229
- Testing
- Caloric restriction, Omega-3 (fish oil capsules), Resveratrol
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Adult
Effects of RIC on Cognitive Function and Blood Oxygen Levels in Unacclimatized Adult at High Altitude
Several studies have shown cognitive impairment such as memory, perception and learning skill during ascent to high altitudes. However, few studies have directly investigated the effect of high altitudes exposure on attention-a…
- Trial name
- NCT03728114
- Testing
- RIC
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Muscle Strength, Cognitive Function
Fish Oil T Cell Function
The purpose of the study is to examine the effect of dietary n-3 polyunsaturated fatty acid supplementation on subjects' pan CD4+ T cell function, cognition, and muscle function.
- Trial name
- NCT02775084
- Testing
- Fish Oil, Olive Oil
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Eye Health, Vision
The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function
VisionPure™ is a softgel dietary supplement containing fish oil, lutein, zeaxanthin, and vitamin D. The intent of the VisionPure product is to assist in maintaining eye and cognitive health while helping to provide protection…
- Conditions
- Eye Health, Vision, Cognitive Function
- Trial name
- NCT05533658
- Testing
- VisionPure Dietary Supplement
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Cognitive Function, Academic Performance
Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex.
- Conditions
- Cognitive Function, Academic Performance, Mental Health
- Trial name
- NCT02240264
- Testing
- Krill oil capsules
- Where
- 17 sites in Netherlands
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Open University
Aging Well, Aging Problems
Aquatic Exercise for Cognition and Mobility in Older Adults
The purpose of this study is to assess the effects of an aquatic exercise program on cognition and physical function of older adults.
- Conditions
- Aging Well, Aging Problems, Cognitive Change, Gait, Unsteady
- Trial name
- NCT05501249
- Testing
- Aquatic Integrated Cognitive Motor Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emily Dunlap
Cognition
Acupoint Stimulation Improves Cognition Under Hypoxia
Cognitive impairment is common in people who suffer from hypoxia. Acupuncture and related techniques can be used to improve hypoxia and treat cognitive impairment.
- Trial name
- TREACLE (NCT06521632)
- Testing
- transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zhihong LU
Cognitive Function
Acute Effects of Cold Exposure on Cognitive Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
- Trial name
- NCT06654167
- Testing
- Low temperature (15℃) group, Moderate temperature (22℃) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Athletic Performance
Alpha-GPC and Physical and Cognitive Performances in Volleyball Players.
In order to attain the elite level on the national scene, volleyball players need several attributes. In addition to mastering technical and tactical skills, great jumping ability is another important asset.
- Trial name
- VolleyAGPC (NCT02886130)
- Testing
- Experimental
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Aging
Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- mTOR (NCT04742777)
- Testing
- rapamycin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio