Clinical trials: Cognitive/Functional Effects
Type 2 Diabetes Mellitus
Effects of Aerobic Training on Pancreatic Fat and Cognitive Function in T2DM Patients
The primary aim of this study was to evaluate the difference in cognitive function and brain functional structure between exercise group and control group by performing regular one-year moderate-intensity aerobic training in type…
- Trial name
- NCT04489966
- Testing
- Aerobic training
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Brain-derived Neurotrophic Factor (BDNF), Cognitive Function
Whole Coffee Fruit Concentrate Pilot Study 1
The purpose of this pilot study is to evaluate the potential effects of whole coffee fruit concentrate (WCFC, Neurofactor), a product that elevates circulating brain-derived neurotrophic factor (BDNF), on cognition and mood in…
- Conditions
- Brain-derived Neurotrophic Factor (BDNF), Cognitive Function, Affect
- Trial name
- WCFC (NCT01965795)
- Testing
- Whole Coffee Fruit Concentrate (WCFC), Nutrim
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cognitive Aging
Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People
Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective.
- Trial name
- NCT02985580
- Testing
- Blueberry
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Postoperative Cognitive Dysfunction
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block combined with intraoperative infusion of s-ketamine on postoperative acute pain and cognitive function in patients with thoracoscopic surgery
- Trial name
- NCT05341375
- Testing
- Thoracic paravertebral block, Esketamine, Measurement of cognitive function
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
COPD
Effects of Combined Cognitive Rehabilitation in COPD Patients
This study was to examine the effect of endurance training combined with cognitive training in patients with COPD. The intervention group underwent Cognitive Training added to Endurance Training and the control group underwent…
- Trial name
- NCT03907839
- Testing
- clinical trials
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculty of Medicine, Sousse
Elderly (people Aged 65 or More)
Leg Press Power Training with Visual Feedback Games Improves Physical, Cognitive, and Heart Health in Seniors
This study investigates the effects of lower limb leg press power training combined with visual feedback games on the physical performance, cognitive function, and heart rate variability (HRV) of older adults aged 65 and above.
- Trial name
- LPPT-VFG (NCT06714175)
- Testing
- Lower Limb Strength Training Program with Visual Feedback
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Mood (Psychological Function)
Effect of Relora Supplement on Anxiety, Cognitive Performance & Mood Tested After Induced Stress
The present randomized, double-blind, placebo-controlled crossover trial aims to evaluate the effects of Relora supplementation on responses to induced stress produced by a combination of cognitive and physiologic stressors in…
- Trial name
- NCT02734251
- Testing
- Relora
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- InterHealth Nutraceuticals, Inc.
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sports Performance, Cognitive Performance During Physical Activity
Multi-Ingredient Supplementation in Professional Football Players
This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive…
- Conditions
- Sports Performance, Cognitive Performance During Physical Activity, Fatigue, Recovery
- Trial name
- TCP-Soccer (NCT07604519)
- Testing
- taurine, Caffeine, Phosphatidylserine
- Where
- 5 sites in Hungary, Poland and 1 more
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Vizja University in Warsaw
Executive Function, Cognitive Performance
Acute Effects of Moderate-Intensity Swimming Exercise on Inhibitory Control, Cognitive Flexibility, and Selective Attention
This randomized controlled trial aims to investigate the acute effects of a single session of moderate-intensity freestyle swimming exercise on cognitive performance in healthy young adults.
- Conditions
- Executive Function, Cognitive Performance, Selective Attention, Inhibitory Control
- Trial name
- SWIMCOG (NCT07670104)
- Testing
- Moderate-Intensity Freestyle Swimming Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Görkem Açar
Cognitive Impairment
The Effect of Upper Limb Low-intensity Motor Control Training Program on Cognitive Function in Healthy Older Adults
This healthy volunteer intervention study is designed to evaluate the effectiveness of upper limb motor control training (uMCT) on physical and cognitive functions in older adults.
- Trial name
- uMCON (NCT06962722)
- Testing
- Upper limb motor control training (uMCON)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Old Age; Debility
Puzzle Game Strategy on Older Adults
One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts…
- Trial name
- PUZZLEOLDER (NCT06459492)
- Testing
- puzzle game strategies
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Attention Deficit Hyperactivity Disorder
Taekwondo Practice in Adolescents With Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neuro-developmental/behavioral disorders among adolescents.
- Trial name
- NCT03678844
- Testing
- Taekwondo practice, CONTROL
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Genova
Attention, Cognition
Acute Effects of Mango Leaf Extract on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study
The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of a single dose (300 mg) of Mango Leaf Extract compared to a placebo on cognitive function…
- Conditions
- Attention, Cognition, Mood
- Trial name
- NCT05182450
- Testing
- Mango leaf extract capsule
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Effect of Drugs
Comparative Effect of Hypotensive Anaesthesia on Event Related Potentials, Quantitative Electroencephalograghy
AIM OF THE WORK The aim of this work was to compare the effect of hypotensive anaesthesia using Nitroglycerine versus phentolamine on Event related potentials, quantitative Electroencephalograghy and cognitive function, in…
- Trial name
- NCT04110808
- Testing
- hypotensive anaesthesia using Nitroglycerine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Cognitive Performance, Academic Performance
Acute Effects of Active Breaks and Physically Active Learning in University Students
This multicenter randomized crossover study will examine the acute effects of four classroom break conditions on executive functions, immediate academic performance, perceived exertion, and interest-enjoyment in university…
- Trial name
- PAL UNI (NCT07809750)
- Testing
- Sedentary Academic Review, Active Break, Physically Active Learning
- Where
- Spain
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Schizophrenia, Schizoaffective Disorder
Galantamine for Cognition in People With Schizophrenia
This study is a double-blind, placebo-controlled trial of the nicotinic receptor agonist, galantamine, for the improvement of memory and attention in people with schizophrenia and schizoaffective disorder.
- Trial name
- NCT00320736
- Testing
- galantamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Sleep Disturbances
Bonafide Sleep Supplement for Menopausal Women With Impaired Sleep
This open-label study evaluated whether a daily dietary sleep supplement could improve sleep and related daytime functioning in menopausal women aged 40 to 65 with impaired sleep.
- Trial name
- NCT07839299
- Testing
- S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Psychosis
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
Background Psychosis is a mental health condition that affects around 3 in 100 people in their lifetime. Most treatments for psychosis target a brain chemical called dopamine but they don't work for everyone and don't address…
- Trial name
- LEVHIPPRO (NCT06224530)
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- King's College London
Long Covid
The Effect of Acupuncture Treatment on Cognitive Functions and Brain Networks for Long COVID
Background of study: Long COVID(LC) is a prevalent sequalae of SARS-CoV-2 infection and can affect multiple organ systems. Cognitive dysfunction is one of the most common symptoms in LC with 22% prevalence.
- Trial name
- NCT07355751
- Testing
- Acupuncture
- Where
- 2 sites in China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Tingting Luo