Clinical trials: Cognitive Aging
Aging, MCI
Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation
The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of…
- Trial name
- NCT06633952
- Testing
- MediTrain, Worder, noninvasive neurostimulation device
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging, Cognitive Decline
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and…
- Conditions
- Aging, Cognitive Decline, Older Adults, Cardiovascular
- Trial name
- FOES (NCT07000734)
- Testing
- Risk managment, Dasatinib, Quercetin (dietary supplement)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Alzheimer Disease, Aging
Vanderbilt Memory and Aging Project
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults.
- Conditions
- Alzheimer Disease, Aging, Aged, 80 and Over, Biomarkers
- Trial name
- VMAP (NCT05372159)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Frailty, Mild Cognitive Impairment
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction.
- Conditions
- Frailty, Mild Cognitive Impairment, Aging
- Trial name
- Mito-Frail (NCT06027554)
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- UConn Health
Healthy Aging, Cognitive Benefits
Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences…
- Conditions
- Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
- Trial name
- ExBrain (NCT07727577)
- Testing
- High-Intensity Interval Training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colby-Sawyer College
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Dementia Risk Cognitive Decline Cognitive Impairment Healthy Cognitive Aging
Effects of Lifestyle and Cognitive Play-Based Nursing Intervention on Dementia Risk
This study evaluated whether a nurse-led lifestyle modification program combined with cognitive play-based training could reduce dementia risk among older adults living in residential care homes.
- Trial name
- Dementia (NCT07747610)
- Testing
- A structured nurse-led multidomain intervention
- Where
- Jordan
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Al-Zaytoonah University of Jordan
Physical Inactivity, Aging
Motivating Activity Through Text Communications - Helping Adults Increase Movement
The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and…
- Conditions
- Physical Inactivity, Aging, Cognitive Ability, Behavior Change
- Trial name
- MATCH AIM (NCT07593677)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4
This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT07414680
- Where
- 2 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment (MCI), Healthy Aging
cMIND AI Web Tool Usability Study (Hong Kong)
This study is testing a new web-based tool that uses artificial intelligence (AI) to help older adults in Hong Kong check how healthy their Cantonese-style meals are for brain health.
- Conditions
- Mild Cognitive Impairment (MCI), Healthy Aging, Nutrition
- Trial name
- NCT07735013
- Testing
- Web-Based AI Dietary Assessment System
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Aging, Cognitive Decline
ACHIEVE Brain Health Follow-Up Study
The ACHIEVE Brain Health Follow-Up Study is a 3-year follow-up to the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study to determine the long-term effect of hearing intervention vs.
- Conditions
- Aging, Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- ACHIEVE-BHFU (NCT05532657)
- Testing
- Hearing intervention, Successful aging/delayed hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 629 people
- Sponsor
- Johns Hopkins University
Aging, Cognitive Performance
Visual Stimulus-Based Cognitive-Motor Agility Exercise in Older Adults
This randomized controlled trial examined the effects of adding a brief visual stimulus-based cognitive-motor agility exercise component to a multicomponent exercise program in community-dwelling older adults.
- Conditions
- Aging, Cognitive Performance, Psychomotor Performance, Exercise
- Trial name
- NCT07714148
- Testing
- Multicomponent Exercise Program, Visual Stimulus-Based Cognitive-Motor Agility Exercise, Time-Matched Low-Intensity Activities
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aging, Aging Problems
Brain Health Virtual Reality Study
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa.
- Conditions
- Aging, Aging Problems, Memory Loss, Memory Impairment
- Trial name
- NCT06124339
- Testing
- Physical Activity, Cognitive Activity (VR), Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aging, Cognitive Decline
Social and Cognitive Online Training: the SCOT Project
Social isolation and reduced involvement in cognitive activities are associated with repercussions on cognitive well-being and health status in elderly adults.
- Trial name
- SCOT (NCT05023187)
- Testing
- SCOT, CON
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Aging, Institutionalized Older Adults
Effects of Exercise, Cognitive Training, and Their Combination in Institutionalized Older Adults
The goal of this clinical trial is to learn if physical exercise, cognitive stimulation, or a combination of both can improve mobility, cognitive function, and psychosocial well-being in institutionalized older adults aged 65 and…
- Conditions
- Aging, Institutionalized Older Adults, Cognitive Abilities, Mobility and Independence
- Trial name
- NCT07082504
- Testing
- Physical Exercise Program, Cognitive Stimulation Program, Combined Physical Exercise and Cognitive Stimulation
- Volunteers
- 140 people
- Sponsor
- University of Salamanca
Aging and Cognitive Health, Healty
PotenziaMente: A Digital Executive Function Training Intervention for Healthy Aging in the Elderly Population
The study, entitled "PotenziaMente: Cognitive Training in Aging," is a clinical trial designed to evaluate the effectiveness of an individualized tablet-based cognitive training program targeting executive functions (e.g.…
- Trial name
- NCT07639203
- Testing
- Remote Cognitive Training, Supervised In-Person Cognitive Training
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Mild Cognitive Impairment, Cognitive Dysfunction
Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Impairment
The purpose of this study is to find out if adding virtual reality (VR) to a cognitive training program helps improve cognitive performance in older adults with mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Cognitive Dysfunction, Aging
- Trial name
- RVEC-DCL (NCT06977815)
- Testing
- VR-Enhanced Cognitive Rehabilitation, Standard Cognitive Rehabilitation
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Badalona Serveis Assistencials
Conditions or Focus of Study: Cognitive Function Loneliness Aging Physical Activity
Wearable-Assisted Walking for Cognitive Function and Loneliness in Older Adults
Participants in the wearable-assisted walking group were asked to walk five days per week for approximately 30 minutes per session at moderate intensity.
- Trial name
- WAW-CogLon (NCT07650292)
- Testing
- Wearable-Assisted Walking Program
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan College of Performing Arts
Older Adults With Cognitive Decline, Insulin Resistance Syndrome
Glycine Supplementation Improves Cognitive Performance in Mexican Older Adults
The purpose of this study was to evaluate the effects of daily glycine supplementation on metabolic health and cognitive performance in older adults.
- Conditions
- Older Adults With Cognitive Decline, Insulin Resistance Syndrome, Aging
- Trial name
- Glycine (NCT07643675)
- Testing
- Glycine
- Where
- Mexico
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Brenda Sarahí Beristain Lujano