Clinical trials: Cognitive Aging
Brain Stimulation, Alzheimer Disease
Transcranial Alternating Current Stimulation (TACS) for Sleep Disturbances in Neurocognitive Disorders Due to Alzheimer's Disease
Background: Sleep disturbances are highly prevalent in ageing population and patients with age-related neurodegenerative diseases, which severely affect cognition and even lead to accumulated amyloid-β (Aβ).
- Conditions
- Brain Stimulation, Alzheimer Disease, tACS, Sleep Disturbance
- Trial name
- NCT05544201
- Testing
- High-definition transcranial current stimulation
- Where
- Hong Kong
- Volunteers
- 99 people
- Sponsor
- Chinese University of Hong Kong
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cognitive Dysfunction, Motor Skills Disorders
Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Iraqis
This study investigates the impact of sociodemographic, psychological, and quality of life factors on dual-task performance in elderly individuals living in Iraq.
- Conditions
- Cognitive Dysfunction, Motor Skills Disorders, Aging
- Trial name
- SociQ-DT (NCT06476561)
- Testing
- - Sociodemographic Assessment - Psychological Assessment - Quality of Life Assessment - D
- Where
- Turkey (Türkiye)
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Edentulism, Biological Aging
Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients
This study aims to investigate the association between full-arch implant-supported fixed dental rehabilitation and changes in biological aging among adults with complete tooth loss (edentulism).
- Trial name
- NCT07890753
- Testing
- Full-Arch Implant-Supported Fixed Dental Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Traumatic Brain Injury, Aging
The Long-term Consequences After Traumatic Brain Injury in the Elderly
A better understanding of the injury patterns, injury severity, risk profiles, consequences and impact of Traumatic Brain Injury (TBI) in the elderly population is necessary due to the increasing incidence and prevalence of TBI…
- Conditions
- Traumatic Brain Injury, Aging, Cognitive Impairment, Quality of Life
- Trial name
- NCT04074850
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity & Overweight
Multimodal Intervention for Weight Management and Health in the Elderly Population
Aging may be accompanied by changes in body composition, muscle strength, metabolic health, and well-being. In older adults with overweight or obesity, strategies that combine physical exercise, behavioral changes, and…
- Trial name
- NCT07820774
- Testing
- Nutritional guidance focused on adopting a high-protein diet., Group Cognitive Behavioral Therapy Intervention, Resistance Training Program
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Aging
Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults
The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in adults aged 60 to 80 with stable health.
- Trial name
- NCT06068803
- Testing
- Ketone drink
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Physical Activity
Supervised Group-based Walking Intervention Among Inactive Older Adults in Saudi Arabia
The purpose of the proposed study is to compare the effects of supervised group-based walking and non-supervised individual-based walking interventions on frailty, cognitive function and quality of life among inactive older…
- Trial name
- NCT05151575
- Testing
- supervised group-based walking and non-supervised individual-based walking interventions
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Aging, Cognitive Change
Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging
Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly…
- Conditions
- Aging, Cognitive Change, Neurocognitive Disorders, Mild
- Trial name
- DecidingBrain (NCT05457725)
- Testing
- Contingent rtfMRI neurofeedback training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Florida
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
Cognitive Decline, Cognitive Function
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
This study will evaluate the efficacy of 1MD Nutrition's MindMD supplement in improving and maintaining cognitive function and memory.
- Trial name
- NCT06523218
- Testing
- MindMD Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Traumatic Brain Injury, Aging Related Cognitive Decline
Remote Stimulation and Training to Advance Recovery From TBI in Seniors
The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI).
- Trial name
- ReSTART (NCT07332299)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Aging
Mind-body Interventions for Healthy Aging
The goal of this study is to examine the impact of mind-body interventions in enhancing behavioral and neural correlates of attentional control in older adults.
- Trial name
- HealthyAgers (NCT03626532)
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Lifestyle Education (LifeEd)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Mild Cognitive Impairment (MCI), Amyloid Pathology
Using Light Therapy for Mild Cognitive Impairment
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and…
- Trial name
- LTMC (NCT07651787)
- Testing
- Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Physical Functional Impairment, Cognitive Impairment
Community Recreation to Enhance Function in Aging
This aim of this study is to examine the therapeutic impacts of a group-based recreational program that delivers guided visual artmaking and dual-task exergaming, to older adults.
- Trial name
- NCT07104435
- Testing
- Artmaking and exergaming
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Age-related Cognitive Decline, Age-related Physiology Decline
Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline
The primary goal is to develop a multidomain intervention program focused on preserving global or regional brain volume and functions while simultaneously improving physical mobility and cognitive functions in older individuals…
- Trial name
- NCT05828043
- Testing
- Multi-domain intervention
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- National Yang Ming Chiao Tung University
Quality of Life, Aging
Effects of Functional Training by High Intensity Intervals in Older Adults With Mild Cognitive Impairment.
To analyze the effects of a high intensity interval functional training program (HIFT), in the cognitive and functional capacities of Colombian older adults with mild cognitive impairment.
- Trial name
- NCT04638322
- Testing
- HIFT Group
- Where
- Colombia
- Volunteers
- 52 people
- Sponsor
- University of Jaén
Aging, Alzheimer Disease
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's…
- Conditions
- Aging, Alzheimer Disease, Life Style, Healthy, Exercise
- Trial name
- LIBRA-NET (NCT06986096)
- Testing
- Aerobic-strength training and nutritional counseling, Cognitive training and stretching.
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- Slovak Academy of Sciences
Age-Related Loss of Skeletal Muscle Mass, Aging
Agility Training for Older Adults to Improve Fall Risk Factors
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as…
- Conditions
- Age-Related Loss of Skeletal Muscle Mass, Aging, Sarcopenia, Cognitive Decline
- Trial name
- AgilE (NCT05727254)
- Testing
- Agility training, Exercise recommendations, Exercise diary
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oliver Faude
Mild Cognitive Impairment
CBD for Individuals at Risk for Alzheimer's Disease
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with…
- Trial name
- NCT05822362
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Colorado, Denver