Clinical trials: Cognitive Changes
Cognitive Change
Semaglutide and Cognition in Healthy Volunteers
Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RA). It is a safe medication approved for use in type-2 diabetes mellitus (T2DM) and obesity.
- Trial name
- OxSENSE (NCT06363487)
- Testing
- Semaglutide, 0.5 mg/mL
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Alzheimer Disease, Mild Cognitive Impairment
Atlas of Retinal Imaging in Alzheimer's Study
The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia, Aging
- Trial name
- ARIAS (NCT03862222)
- Testing
- Retinal Imaging, Pupillometry, Contrast Sensitivity
- Where
- 4 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Oral Manifestations, Child Behavior
Change in Hygiene and Sugar Comsuption Habits After Use of Cognitive Behavioral Therapy in Pediatric Dentistry in Twins
The objective of this study is to verify the changing habits and their maintenance after using cognitive behavioral therapy, exploring factors that may be associated with these stages and the moment in which they occur.
- Conditions
- Oral Manifestations, Child Behavior, Adolescent Behavior, Change; Cognitive
- Trial name
- CARDEC-BC (NCT06961890)
- Testing
- Principals of cognitive behavioral therapy on guided changing hygiene and sugar comsuption habits
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cognitive Change
Examining the Effectiveness of Cognitive Training
The present study addresses whether placebo effects can possibly account for previous findings in the field, as well as ascertains whether placebo-based mechanisms can be deliberately harnessed for impact.
- Trial name
- NCT04344028
- Testing
- True Cognitive Training Program, Control Cognitive Training Program, Positive Expectation Induction
- Where
- 3 sites in United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Adolescent Behavior, Dental Plaque
Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)
This is a Phase III, randomized, one-center, three arm parallel group, open label and single blind clinical study to evaluate the effectiveness of a cognitive behavioral intervention (CBI) adjunctive to a smart powered toothbrush…
- Conditions
- Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
- Trial name
- NCT05782348
- Testing
- Cognitive behavioral intervention, Colgate smart toothbrush
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Howard University
Cognitive Change
COgnitive Dynamics in Early Childhood
The goal of this accelerated longitudinal observational cohort study is to advance our understanding of cognitive variability in children aged 7 to 10 at first measurement.
- Trial name
- CODEC (NCT06330090)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cognitive Change
Altering Multitasking Behavior Using Low Current Brain Stimulation
This study is designed to investigate multitasking deficits, with a particular interest in reducing costs related to dual-tasking (dividing attention between tasks) and task-switching (switching between tasks) using noninvasive…
- Trial name
- NCT03873636
- Testing
- Stimulation via noninvasive brain stimulation systems
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tufts University
LPS, Mood Disorders
Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults
Given its capacity to stimulate exercise-induced neuroplasticity at lower doses compared to aerobic exercise, resistance exercise has become the top-recommended rehabilitation approach for individuals with neurocognitive…
- Conditions
- LPS, Mood Disorders, Cognitive Change
- Trial name
- NCT06437405
- Testing
- Vinegar liquid, vinegar pill
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Trauma, Stress, Emotional
Cognitive Appraisals and Team Performance Under Stress in Simulated Trauma Care
Medical teams work in demanding situations that are often uncertain, changeable and require accurate decision-making, skilled movement and coordinated action. How teams perform matters for patient outcomes.
- Conditions
- Trauma, Stress, Emotional, Cognitive Change
- Trial name
- NCT05083871
- Testing
- European Trauma Course
- Where
- Italy
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Azienda Usl di Bologna
Normal Cognition, Cardiovascular Risk Factors
Cardiovascular Risk Factors and Cognitive Trajectories
The cognitive trajectory varies among non-demented older adults. In a 12-year follow-up study, we found approximately 5% participants presented rapid cognitive decline.
- Conditions
- Normal Cognition, Cardiovascular Risk Factors, Cognitive Change, Cerebral Blood Flow
- Trial name
- NCT05441865
- Where
- China
- Volunteers
- 3,372 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Noise Exposure, Sleep Disturbance
Effects of Railway Vibration on Sleep and Disease
This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease.
- Conditions
- Noise Exposure, Sleep Disturbance, Sleep Hygiene, Metabolic Disturbance
- Trial name
- BioVib (NCT06260254)
- Testing
- Railway noise, Low level railway vibration, Intermediate level railway vibration
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Cognitive Change
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults
The present study investigates how individual differences in cognitive processing contribute to the efficacy of working memory training programs in an older adult population.
- Trial name
- NCT05396586
- Testing
- N-back, Span, Multisensory
- Where
- 2 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Cognitive Change, Mood
Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adults
The Pleurotus oyster species is a common edible mushroom rich in phytochemicals such as proteins, phenolic compounds, dietary fibre and is also particularly rich in ergothioneine, a bioactive known for its neurocognitive…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSCOG (NCT06846827)
- Testing
- Oyster mushroom, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading
Aerobic Exercise, Cognitive Change
The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults
Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated…
- Trial name
- TEEMY (NCT04861818)
- Testing
- Moderate-intensity aerobic exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Diet Modification, Cognitive Decline
Multicultural Healthy Diet to Reduce Cognitive Decline
This is a pilot randomized controlled clinical trial is designed to investigate whether the Multicultural Healthy Diet (MHD), an anti-Inflammatory diet tailored to a multi-cultural population, can improve cognitive functioning in…
- Conditions
- Diet Modification, Cognitive Decline, Cognitive Change
- Trial name
- MHD (NCT03240406)
- Testing
- Multicultural Healthy Diet, Usual Diet plus Self-Care
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Cognitive Change, Well-Being, Psychological
Trout Consumption in Young Children and Families and Brain Health
Regular fish consumption may support brain health. Trout lines developed in Idaho contain higher levels of omega-3 fatty acids, nutrients important for human cognition and mental wellbeing.
- Trial name
- NCT06721468
- Testing
- Trout, Child-centered nutrition phrases, Puzzle
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Aging, Cognitive Change
Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
- Trial name
- NCT05652140
- Testing
- Data collections
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Cognitive Change
The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine
Single-center, randomized, double-blind, placebo-controlled, proof-of-principle study to evaluate potential cognitive benefits of a single oral dose of AVL-3288 (3 mg) in the presence and absence of transdermal nicotine (7 mg/24…
- Trial name
- NCT03281694
- Testing
- Nicotine, AVL-3288, Nicotine + AVL-3288
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cognitive Change
A Clinical Study on the Effect of DHA & ARA Candy on the Cognitive Improvement in Preschool Children
The goal of this interventional study is to evaluate the effectiveness of DHA (docosahexaenoic acid) \& ARA (arachidonic acid) Candy on the cognitive development of preschool children (2-6 years old).
- Trial name
- NCT06532435
- Testing
- DHA & ARA Candy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong Sibote Biotechnology Co., Ltd.