Clinical trials: Cognitive Changes
Intolerance to Uncertainty
The Effectiveness of Cognitive Bias Modification on Intolerance of Uncertainty
The current study aims to reduce the intolerance of uncertainty levels with an internet-based cognitive bias modification intervention in young adults with high levels of intolerance to uncertainty aged between 18 and 40.
- Trial name
- NCT06174311
- Testing
- Active Cognitive Bias Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
Healthy
Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
This study is designed to look at the potential for an investigational drug (PF-04995274, under development by Pfizer, Inc. as a potential treatment for Alzheimer's disease) to reverse changes in memory and learning/problem…
- Trial name
- NCT01345864
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Age-Related Macular Degeneration
Brain Connectivity in Age-Related Macular Degeneration
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function.
- Trial name
- NCT01996215
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Duke University
Psychological Distress, Quality of Life
The Effectiveness of Culturally Adapted Cognitive Behavioral Intervention Among COVID-19 Survivors
The effectiveness study for Culturally-Adapted Cognitive Behavioral Intervention (CA-CBI) will be conducted with individuals infected with and recovered from Coronavirus disease (COVID-19) to measure if this intervention is…
- Conditions
- Psychological Distress, Quality of Life, Depressive Symptoms, Anxiety
- Trial name
- NCT04949061
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI), Enhanced Treatment as Usual (ETA-U)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Koç University
Cognitive Change
Decision Making in Video Games
The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right…
- Trial name
- NCT03869489
- Testing
- Anodal left dorsolateral prefrontal cortex tDCS stimulation, Anodal right dorsolateral prefrontal cortex tDCS stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Psychological Distress, Well-being
The Effectiveness of a CA-CBI on Psychological Distress of University Students During the COVID-19 Pandemic
The effectiveness study for Culturally Adapted Cognitive Behavioral Intervention will be conducted with university students to measure if this intervention if effective for decreasing the university students' psychological…
- Trial name
- NCT04858789
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI)
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Koç University
Psychological Stress, Anxiety
Mindfulness Training in U.S. Army Cohorts
This project aims to contextualize delivery of mindfulness training to U.S. Army personnel, evaluate its effectiveness on measures of executive functions and psychological well-being, and determine best practices for its delivery.
- Conditions
- Psychological Stress, Anxiety, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT03310112
- Testing
- 4-week MBAT, 2-week MBAT
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Miami
Overweight, Physical Capacity
Physical Exercise, Dietary Counseling and Cognitive Behavioral Training as a Combined Intervention to Reduce Weight and Increase Workability in Health Care Workers
The purpose of this study is to evaluate whether a 1 year worksite based life-style intervention can reduce body weight and increase physical capacity and subsequently reduce musculoskeletal disorders and increase workability in…
- Conditions
- Overweight, Physical Capacity, Musculoskeletal Diseases, Work Ability
- Trial name
- FINALE-Health (NCT01015716)
- Testing
- Intervention-group, Control-group
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Enhanced Internet Behavior Therapy for Treating Obesity
The purpose of this study is to compare two Internet-based behavioral weight loss programs.
- Trial name
- NCT00212238
- Testing
- internet behavioral weight loss program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia, Psychotic Disorders
Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis
The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and…
- Conditions
- Schizophrenia, Psychotic Disorders, Delusions, Emotions
- Trial name
- CBTd-E (NCT02787135)
- Testing
- emotion-oriented Cognitive Behavior Therapy
- Where
- 2 sites in Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Cognitive Impairment
Changes in Cognition During a 24-h Simulated Military Operation
Sustained military operations (SUSOPs) result in psychological stress and cognitive dysfunction, which may be related to the recruitment of classical monocytes into the brain.
- Trial name
- NCT04250480
- Testing
- beta-alanine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Implant Supported Overdenture
Impact of Implant Supported Overdenture on Changes of Electromyographic and Brain Activity
The purpose of this study is to evaluate and compare the effects of a mandibular implant-supported overdenture with a mandibular complete denture on electromyographic activity, brain activity, and cognitive performance in…
- Trial name
- NCT05493579
- Testing
- Implant supported overdenture
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Brain Structure, Cognitive Performance
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and…
- Trial name
- NCT04856410
- Testing
- Spaceflight, Controls
- Where
- 3 sites in United States, Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cognitive Impairment, Coginitive Assessment
A Modified Test of Goal-directed Behaviour: a Feasibility Study
Cognitive assessment plays an important part in decision making in acute neurological settings, partly because difficulties with cognitive skills such as attention, memory and executive functioning (which includes planning and…
- Trial name
- NCT07484048
- Testing
- Five cognitive tasks
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Stroke, Trauma
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40.
- Conditions
- Stroke, Trauma, Cognition, Agency
- Trial name
- FUSCBM (NCT07389447)
- Testing
- Focused ultrasound, EEG
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
PTSD
Prevention of Post Traumatic Stress Disorder Following Trauma by Attention Control Training
The purpose of this study is to explore the efficacy of Attention Control Training in preventing the development of Post Traumatic Stress Disorder (PTSD), during the period near after a traumatic event and before PTSD is develop.
- Trial name
- NCT02591485
- Testing
- Attention Control Training
- Where
- Israel
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Yair Bar-Haim
Obesity, Morbid
Suboptimal Weight Loss After Gastric Bypass Surgery
Bariatric surgery is the only long-term established treatment for morbid obesity. However, some patients experience suboptimal weight loss after surgery and/or experience a significant weight regain.
- Trial name
- NCT01829906
- Testing
- Multidisciplinary outpatient programme, Inpatient lifestyle programme
- Where
- Norway
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University