Clinical trials: Cognitive Disorders
Stroke, Spinal Cord Injury
Synergistic Effect of Non-invasive Brain and Spinal Cord Stimulation
The goal of this clinical study is to investigate the potential synergy between non-invasive brain and spinal cord stimulation administered during a cognitive-motor task, in terms of their immediate effects on sensorimotor and…
- Conditions
- Stroke, Spinal Cord Injury, Able Bodied
- Trial name
- BrainSpineStim (NCT07334977)
- Testing
- tDCS, tSCS, Cognitive-Motor Task
- Where
- 2 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Mild Cognitive Impairment
Applying a Person-Centered Approach to Enhance Cognitive Training in Senior Living Community Residents With Mild Cognitive Impairment
Computerized cognitive interventions (CCIs) have been increasingly widely implemented among older adults with mild cognitive impairment (MCI).
- Trial name
- CogT-PACT (NCT03292705)
- Testing
- PEP, CCI
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Developmental Coordination Disorder
Motor-Cognitive Integrated Intervention for Children With Developmental Coordination Disorder
The goal of this clinical trial is to evaluate the efficacy of an Action Observation and Motor Imagery (AOMI) combined with Fundamental Movement Skills (FMS) intervention for children aged 7 to 11 years with Developmental…
- Trial name
- NCT07486856
- Testing
- Action Observation and Motor Imagery (AOMI) Training, Fundamental Movement Skills (FMS) Training, General Physical Activities
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Parkinson Disease
Comparison of Different Non-invasive Electrical Stimulation Protocols to Facilitate Rehabilitation in Parkinson's Disease Subjects With Postural Instability and Gait Disorders
The trial will include 51 adult participants with Parkinson's disease and postural instability and gait disorders (PD-PIGD) and 20 age- and sex-matched healthy controls.
- Trial name
- NCT06868160
- Testing
- Rehabilitation, tDCS, tsDCS (first cycle)
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
CADASIL
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID).
- Trial name
- NCT05677880
- Testing
- Study Procedures
- Where
- 12 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Fetal Alcohol Syndrome
In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions
This study aims to validate that PLGF is a biomarker of cerebral lesions and therefore of secondary developmental disorders and disabilities that will be best diagnosed at 2 and 6 years of age.
- Trial name
- ALCOBRAIN (NCT03371641)
- Testing
- ASQ parental questionnaire, Development scales, Scale of Conners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
ADHD
Effects of a Cognitive Training Program With Game Elements Among ADHD
This study examines the impact of cognitive training among participants with ADHD in Switzerland
- Trial name
- CogtrainADHD (NCT03799029)
- Testing
- Cognitive training
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Alcoholism
Individualized Assessment and Treatment for Alcoholism II
The object of this study is to develop a treatment for alcohol use disorders that is more effective than current CB treatments. Through a 2009 R-21 pilot project the investigators developed a cognitive-behavioral (CB) treatment…
- Trial name
- IATP2 (NCT03233802)
- Testing
- Individualized Assess & Treatment (IATP), Packaged Cognitive-Behavioral (PCBT), Case Management (CaseM)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- UConn Health
Mild Cognitive Impairment
Application and Revision of Montreal Cognitive Assessment in Chinese Retirees
The study was designed to employ MOCA to screen mild cognitive impairment (MCI) in military retirees and to analyze the associated risk factors. As such, MOCA was revised to be validated for the Chinese context.
- Trial name
- ARMOCA (NCT02483754)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Cognitive Disorders
A Study to Investigate the Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-G3031 in Healthy Subjects
The purpose of the study is to investigate the effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-G3031 in Healthy Subjects
- Trial name
- NCT02881294
- Testing
- SUVN-G3031
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-2: Shaping HOME Environments and LifeSTYLES to Prevent Childhood Obesity in SNAP-Education
Childhood obesity prevention efforts are needed in the United States, especially for families with low income. Educating parents and caregivers on simple lifestyle and affordable home environment changes is an effective strategy…
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Child Behavior, Cognitive Change
- Trial name
- NCT05019339
- Testing
- Healthy HomeStyles, Eat Healthy Be Active
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Florida
Postpartum Depression
Peer Administered CBT for PPD
Postpartum depression (PPD) affects up to 20% of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care.
- Trial name
- PL-CBT (NCT03285139)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mild Cognitive Impairment (MCI)
A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to Dementia
This prospective, longitudinal observational cohort study will examine clinical, cognitive, blood-based, and neuroimaging features across the cognitive continuum.
- Trial name
- NCT07876570
- Testing
- Observational Multimodal Assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment, Alzheimer's Disease
Arterial Spin Labeling (ASL) MRI for Cognitive Decline
The purpose of this study is to determine the value of Arterial Spin Labeling (ASL) MRI, a measure of blood flow to the brain, in Mild Cognitive Impairment (MCI) and compare it to existing measures.
- Trial name
- NCT01727622
- Testing
- FDG-PET, ASL-MRI, Lumbar Puncture
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognitive Change, Cognitive Decline
Sleep, Diet, Exercise and Older Persons
To examine the impacts of a cognitive yoga program and circuit resistance training on cognitive and physical performance with nutrition and sleep as modulating factors in healthy, older adults.
- Trial name
- NCT05735353
- Testing
- High-Speed Circuit Resistance Training, High-Speed Multidirectional Yoga
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cognitive Dysfunction
Aprepitant to Mitigate Opioids' Cognitive Side Effects
Morphine and similar substances (called opioids) are often prescribed for moderate to severe pain, such as after a surgery, thus allowing for minimal pain and a better recovery.
- Trial name
- NCT02226601
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Alzheimer Disease and Related Dementias (ADRD), Mild Cognitive Impairment (MCI)
Remote Sensing for ADRD-Specific Activities Identification in Older Adults
The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom…
- Trial name
- NCT07120347
- Testing
- Remote Ambient Sensor System
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
MCI
BRain Energy Activation With Ketones to Prevent Alzheimer's Disease
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS).
- Trial name
- BREAK-AD (NCT04466735)
- Testing
- Active group
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Alzheimer's Disease, Aging
aeRobic Exercise and Cognitive Health
The purpose of the aeRobic Exercise and Cognitive Health (REACH) study is to understand how an aerobic exercise intervention might help promote brain health and cognition, thereby delaying the onset of clinical symptoms of…
- Trial name
- REACH (NCT02384993)
- Testing
- Enhanced Physical Activity
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Social Anxiety Disorder
Cognitive Behavioural Therapy as an Effective Treatment for Social Anxiety, Perfectionism, and Rumination
This randomized, controlled trial study was designed to examine the efficacy of Cognitive Behavioural Therapy (CBT) on social anxiety, perfectionism, and rumination among individuals diagnosed with social anxiety in Tehran, Iran.
- Trial name
- NCT03946735
- Testing
- Cognitive Behavioural Therapy as an Effective Treatment for Social Anxiety, Perfectionism, and Rumination
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alzahra University
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