Clinical trials: Cognitive Disorders
Cognitive Deficit
Patient-Centered NeuroRehabilitation (PCN)
As individuals grow older, a number of factors can reduce our cognitive (or thinking) abilities such as "normal" aging, neurodegenerative diseases, and cardiovascular disease.
- Trial name
- PCN (NCT03036319)
- Testing
- Active tDCS, Cognitively based intervention, Active tACS
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Huntington Disease
Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease
This study will investigate if a new experimental drug to treat Huntington's Disease gets into the brain. If it does get into the brain the study will explore the relationship between the amount of drug in the brain and the…
- Trial name
- NCT01602900
- Testing
- GSK356278, Rolipram
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vascular Cognitive Impairment, Alzheimer Disease
Multimodal Biomarkers for Diagnosis and Prognosis in VCI
We will try to 1. establish the correlation of plasma Aβ40 and Aβ42 level, ApoE genotype, MRI imaging markers in the diagnosis and prognosis of VCI patients 2. understand more on the pathophysiology of VCI.
- Trial name
- VCI (NCT04604600)
- Testing
- amyloid PET
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obsessive-Compulsive Disorder
Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- NCT03457675
- Testing
- Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period
- Where
- 3 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Sleep, Cardiovascular Diseases
Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers
The purpose of this study is to evaluate the effects of kefir on gastrointestinal health, sleep quality, and biochemical parameters in adults who have sleep problems.
- Conditions
- Sleep, Cardiovascular Diseases, Gut Microbiome, Cognitive Function and Mood
- Trial name
- NCT07071181
- Testing
- Original flavour kefir, Milk
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
Alzheimer's Disease Neuroimaging Initiative 2
The purpose of this study is to build upon the information obtained in the original Alzheimer's Disease Neuroimaging Initiative (ADNI1) and ADNI-GO (Grand Opportunity; a study funded through an NIH grant under the American…
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), Significant Memory Concern (SMC), Early Mild Cognitive Impairment (EMCI)
- Trial name
- ADNI2 (NCT01231971)
- Testing
- Florbetapir, Flortaucipir
- Where
- 58 sites in United States, Canada
- Volunteers
- 1,182 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Psychological Stress, Anxiety
Mindfulness Training in U.S. Army Cohorts
This project aims to contextualize delivery of mindfulness training to U.S. Army personnel, evaluate its effectiveness on measures of executive functions and psychological well-being, and determine best practices for its delivery.
- Conditions
- Psychological Stress, Anxiety, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT03310112
- Testing
- 4-week MBAT, 2-week MBAT
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anxiety, Cognitive Deficit
Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits
This study investigates the potential of cranial electrotherapy stimulation to mitigate anxiety induced cognitive deficits
- Trial name
- NCT04961112
- Testing
- Cranial Electrotherapy Stimulation
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Tufts University
No Condition
Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention.
- Trial name
- CFDDCN (NCT06658392)
- Testing
- cognitive tasks
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Cognitive Dysfunction
Immersive Nature-Based Wellbeing Program in Older Adults With Cognitive Impairment
This study aims to evaluate an immersive virtual reality program designed to support cognitive and emotional well-being in older adults with mild to moderate cognitive impairment.
- Trial name
- COGNITIO (NCT07802392)
- Testing
- Immersive virtual reality program
- Where
- Spain
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Atrial Fibrillation, Heart Failure
Akershus Cardiac Examination (ACE) 1950 Study
Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study.
- Conditions
- Atrial Fibrillation, Heart Failure, Mild Cognitive Impairment, Cardiovascular Diseases
- Trial name
- ACE1950 (NCT01555411)
- Where
- 2 sites in Norway
- Volunteers
- 3,706 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Opioid-use Disorder
Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward processing, as measured by the…
- Trial name
- NCT04432493
- Testing
- Active repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Overweight, Physical Capacity
Physical Exercise, Dietary Counseling and Cognitive Behavioral Training as a Combined Intervention to Reduce Weight and Increase Workability in Health Care Workers
The purpose of this study is to evaluate whether a 1 year worksite based life-style intervention can reduce body weight and increase physical capacity and subsequently reduce musculoskeletal disorders and increase workability in…
- Conditions
- Overweight, Physical Capacity, Musculoskeletal Diseases, Work Ability
- Trial name
- FINALE-Health (NCT01015716)
- Testing
- Intervention-group, Control-group
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alzheimer Disease
Imaging Tau in Alzheimer's Disease and Normal Aging
This study is being done to learn about tau tangles in Alzheimer's disease. A type of positron emission tomography (PET) scan is used to measure the abnormal accumulation of protein called tau in the brain.
- Trial name
- NCT03373604
- Testing
- 18F-MK-6240, Lumbar Puncture (optional)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Internet Gaming Disorder, Emotion Regulation
Emotion and Craving Regulation Among Individuals With Internet Gaming Disorders
To investigate the potential deficits in emotion and craving regulation capacities of drug-naïve young adults with Internet gaming disorder as compared with healthy controls.
- Trial name
- NCT04110548
- Testing
- Emotion Regulation Task, Craving Regulation Task
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Chronic Obstructive Pulmonary Disease, End-of-Life Fear
End-of-Life Fear in Patients With End-Stage Lung Disease (COPD)
The aim of the study is to develop an interview to ask patients with COPD about their fear of death and dying, their needs and wishes at the end-of-life.
- Conditions
- Chronic Obstructive Pulmonary Disease, End-of-Life Fear, Fear About Death and Dying, Depression
- Trial name
- NCT00792974
- Testing
- A brief psycho-educational intervention
- Where
- 2 sites in Germany
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Huntington Disease, Tardive Dyskinesia
Effect of Food on the Pharmacokinetics of LPM3770164 Sustained-release Tablets
This is a A single-center, randomized, open-label, two-dose, two-period, crossover trial was conducted to evaluate the effect of food on the Pharmacokinetic characteristics and safety of oral administration of LPM3770164…
- Trial name
- NCT06474650
- Testing
- LPM3770164 sustained release tablet
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Turner's Syndrome
Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome
RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome.
- Trial name
- NCT00004274
- Testing
- Estrogen
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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