Clinical trials: Cognitive Function Decline
Alzheimer Disease, Dementia
Tablet-based Cognitive Training
Today the therapy options for dementia due to Alzheimer's disease (AD) are limited. One recommended intervention is cognitive stimulation.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT04452864
- Testing
- Computerized Cognitive Training, Documentaries with delayed Computerized Cognitive Training
- Where
- 2 sites in Switzerland
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Bern
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
MCI, Subjective Cognitive Decline
Senior Driving Simulation Training for Subjective Cognitive Decline and Mild Cognitive Impairment
This study aims to establish the Senior Driving Simulation Training (SDST) for Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI), and explore the effectiveness of Senior Driving Simulation Training (SDST) on…
- Conditions
- MCI, Subjective Cognitive Decline, Healthy Aging
- Trial name
- SDST (NCT05380284)
- Testing
- Senior Driving Simulation Training, Waiting list control
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognitive Impairment, Subjective Cognitive Decline
Brain Health Together: Development and Pilot Test
The objectives of this study were to develop and pilot-test Brain Health Together (BHT), a 12-week, virtual-group program that combines our evidence-based, mind-body, group movement program with brain health education and…
- Conditions
- Cognitive Impairment, Subjective Cognitive Decline, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06914947
- Testing
- Brain Health Together
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Muscle Weakness, Bone Health
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment and falls in older adults carry an increased risk for poor health outcomes and if identified early, can be…
- Conditions
- Muscle Weakness, Bone Health, Cognitive Decline
- Trial name
- HOPE-DIET (NCT03786835)
- Testing
- Protein supplementation and regular physical activity
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Alzheimer Disease, Neurodegenerative Diseases
Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION
DECISION Study - Summary Title: Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline The DECISION study aims to develop and validate a simplified yet robust tool for assessing the capacity…
- Trial name
- DECISION (NCT07514520)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer's Disease
Early Markers of Cognitive Change and Alzheimer s Disease
Background: The Baltimore Longitudinal Study of Aging (BLSA) is a long-term study of human aging. To see how the brain changes with age, researchers will study BLSA participants who are at least 60 years old.
- Trial name
- NCT01867346
- Where
- United States
- Volunteers
- 2,850 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging, Cardiovascular Risk Factor
A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without…
- Trial name
- ACTIONcR (NCT04962061)
- Testing
- Cognitive Training, Aerobic and resistance exercises, Stretching and Toning
- Where
- Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Mild Cognitive Impairment, Alzheimer's Disease
Arterial Spin Labeling (ASL) MRI for Cognitive Decline
The purpose of this study is to determine the value of Arterial Spin Labeling (ASL) MRI, a measure of blood flow to the brain, in Mild Cognitive Impairment (MCI) and compare it to existing measures.
- Trial name
- NCT01727622
- Testing
- FDG-PET, ASL-MRI, Lumbar Puncture
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognitive Dysfunction, Cognitive Impairment
CAMCI: Advancing the Use of Computerized Screening in Healthcare
Cognitive impairment is a significant health problem in the United States, resulting in costs over $100 billion a year. We will provide an efficient, effective, and financially intelligent solution to Primary Care Physician's to…
- Conditions
- Cognitive Dysfunction, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- NCT03512301
- Testing
- CAMCI, MoCA, Clinical Adjudication
- Where
- 4 sites in United States
- Volunteers
- 773 people, healthy volunteers welcome
- Sponsor
- Psychology Software Tools, Inc.
Cognitive Decline, Aging
Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing
COMBI is a multi-center, randomized controlled trial among 70 older adults at risk of cognitive decline. The main goal is to investigate the effect of a 6-week colon-delivered multivitamin supplementation on the gut-brain axis in…
- Trial name
- COMBI (NCT05675007)
- Testing
- Colon-delivered multivitamin supplement
- Where
- 2 sites in Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Mild Cognitive Impairment, Dementia, Mild
The Brain Health Champion Study
6-month, randomized, controlled investigation measuring the effect of increased clinical contact and personalization compared to standard physician counseling on adherence to consensus-based, brain health recommendations for…
- Conditions
- Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
- Trial name
- BHC (NCT03772977)
- Testing
- Brain Health Champion
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognitive Impairment, Cognitive Decline
Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults
Previous research has shown that a healthy lifestyle, including a balanced diet, physical and social activity, and management of vascular risk factors can support both cardiovascular and brain health.
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia
- Trial name
- LETHE (NCT05565170)
- Testing
- Structured ICT-assisted multimodal lifestyle intervention, Self-guided multimodal lifestyle intervention
- Where
- 4 sites in Austria, Finland and 2 more
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Cognitive Decline
A Home-based e-Health Intervention in the Elderly: MOVI-ageing
This protocol study aims to evaluate the efficacy of the MOVI-ageing intervention, a complex home-based eHealth intervention of cognitive-demanding exercise for the elderly, in improving: global cognitive function and basic…
- Trial name
- MOVI-ageing (NCT05928078)
- Testing
- intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Mild Cognitive Impairment
Cognitive Assessment of Elderly Primary Care Patients
Most primary care physicians do not screen older patients for cognitive impairment. Identification of cognitive impairment may result in earlier referral for diagnostic work-up and earlier treatment and better patient outcomes.
- Trial name
- NCT01492335
- Testing
- Cognitive Report, Treatment As Usual
- Where
- United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Memory, Cognitive Function Decline
Cognitive Effects of Bioavailable Curcumin
An estimated 50% of older adults complain of memory changes that worsen as they age. Although numerous commercially available dietary supplements claim cognitive benefits, relatively few well-designed, longitudinal…
- Trial name
- NCT07251985
- Testing
- Curcumin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles