Clinical trials: Cognitive Function Decline
Intracranial Atherosclerosis, Cognitive Impairment
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study
The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on…
- Conditions
- Intracranial Atherosclerosis, Cognitive Impairment, Cerebrovascular Event
- Trial name
- NCT06336174
- Testing
- Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin, Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Type 2 Diabetes Mellitus (T2DM), Cognitive Dysfunction
SGLT2 Inhibitors and Cognitive Function in Adults With Type 2 Diabetes (SaveMinD)
This study is a prospective, randomized, open-label trial with blinded outcome assessment (PROBE design) designed to evaluate the effects of sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy on cognitive function in adults…
- Trial name
- SaveMinD (NCT07694596)
- Testing
- SGLT2 Inhibitor, Standard Diabetes Care
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University of Primorska
Subjective Cognitive Decline (SCD)
An Open Label Trial Evaluating the Efficacy of Lacticaseibacillus Paracasei PS23 on Cognition
This open label study aims to evaluate whether the consumption of probiotics can improve symptoms and overall quality of life in individuals experiencing cognitive decline symptoms, as well as to evaluate the effects of…
- Trial name
- NCT07168824
- Testing
- Lacticaseibacillus paracasei
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chi-Chang Huang
Cognitive Decline, Cognitive Change
Dairy Based Probiotic Intervention and Cognitive, Emotional, and Inflammatory Outcomes
The purpose of this study was to determine the effect of dairy-based probiotics on cognitive function, emotional wellbeing, and inflammation.
- Conditions
- Cognitive Decline, Cognitive Change, Inflammation, Emotions
- Trial name
- NCT04643080
- Testing
- Yogurt
- Where
- 4 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Cognitive Impairment, Cognitive Change
Validation of a Digital Self-Administered Cognitive Screening Tool: MoCA-XpressO
The investigators conducted a validation study for the Montreal Cognitive Assessment (MoCA)-XpressO compared to the digital-MoCA test (version 8.1) as the gold standard.
- Conditions
- Cognitive Impairment, Cognitive Change, Cognitive Deficit, Assessment, Self
- Trial name
- MoCA (NCT05879562)
- Testing
- MoCA-Xpresso
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MoCA Clinic and Institute
Cognitive Decline
Cognitive Function in Elderly Marathon Runners
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly.
- Trial name
- APSOEM (NCT01045031)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Diabetes, Diabetes Mellitus Type 2
Cognitive Screening and Multidomain Intervention Targeting Cognitive Decline in Type 2 Diabetes (The Brain Care Study)
The purpose of The Brain Care Study is to investigate the prevalence of cognitive impairment in older adults with type 2 diabetes (T2D) and to evaluate the effectiveness of a multidomain intervention designed to prevent cognitive…
- Conditions
- Diabetes, Diabetes Mellitus Type 2, Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT07250789
- Testing
- Multidomain Intervention Targeting Cognitive Decline
- Where
- 3 sites in Denmark
- Volunteers
- 420 people
- Sponsor
- Steno Diabetes Center Copenhagen
Chronic Pain, Mild Cognitive Impairment
Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT
The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and early cognitive decline.
- Trial name
- NCT07785648
- Testing
- Feeling of Being, Health Enhancement Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognition Disorders in Old Age, Mild Cognitive Impairment
Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment
In this research study we want to learn more about whether taking Niagen, a daily supplement containing a form of Vitamin B3, will improve cognitive function, mood, and daily activity in people with Subjective Cognitive Decline…
- Conditions
- Cognition Disorders in Old Age, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04078178
- Testing
- Niagen
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Steven E Arnold, MD
Insomnia, Cognitive Dysfunction
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals…
- Conditions
- Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05565833
- Testing
- SHUTi OASIS, Patient Education
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Virginia
Cognitive Dysfunction
Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline
The European Commission Horizon 2020 programme has funded the SCD-WELL trial to investigate the efficacy of mindfulness-based training to reduce anxiety in individuals with Subjective Cognitive Decline (SCD), in comparison to an…
- Trial name
- SCD-WELL (NCT03005652)
- Testing
- Mindfulness weekly courses for 8 weeks, Health education weekly courses for 8 weeks
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cognitive Impairment, Cognitive Decline
Music Therapy for Older Adults With Cognitive Decline Living in Care Homes
This research aims to investigate whether the use of music-improvisation therapy for older adult participants can lead to improvements in cognitive ability levels, especially in attentional functions.
- Trial name
- NCT05856604
- Testing
- Music Therapy, Storytelling
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Middlesex University
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Cognitive Impairment, Subjective Cognitive Decline
Brain Health Together: Development and Pilot Test
The objectives of this study were to develop and pilot-test Brain Health Together (BHT), a 12-week, virtual-group program that combines our evidence-based, mind-body, group movement program with brain health education and…
- Conditions
- Cognitive Impairment, Subjective Cognitive Decline, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06914947
- Testing
- Brain Health Together
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Subjective Cognitive Decline
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
- Trial name
- preSmartAge (NCT02755246)
- Testing
- Polyamine supplementation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Older Adults, Depression
Educational and Cultural Engagement and Incidence of Health Adverse Events
This study evaluated if the social and cultural activities decrease the incidence of dementia and frailty conditions.
- Conditions
- Older Adults, Depression, Cognitive Decline
- Trial name
- NCT03987360
- Testing
- Observational
- Where
- Canada
- Volunteers
- 30,000 people
- Sponsor
- Jewish General Hospital
Muscle Weakness, Bone Health
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment and falls in older adults carry an increased risk for poor health outcomes and if identified early, can be…
- Conditions
- Muscle Weakness, Bone Health, Cognitive Decline
- Trial name
- HOPE-DIET (NCT03786835)
- Testing
- Protein supplementation and regular physical activity
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Subjective Cognitive Decline
Β-OHB Supplementation and Brain Health in Older Adults
The goal of this randomized placebo controlled crossover trial is investigate the effects of short-term ketone monoester (KME) supplementation to brain function in older adults with subjective cognitive decline.
- Trial name
- NCT06588946
- Testing
- Ketone monoester (KME) supplement
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- McMaster University