Clinical trials: Cognitive Function Decline
Type2diabetes, Mild Cognitive Impairment
Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
This is a single-arm feasibility study employing a pre-post design with a 12-week intervention period. The study utilizes a telehealth-assisted home-based resistance exercise program, with a structured progression from supervised…
- Conditions
- Type2diabetes, Mild Cognitive Impairment, Age-related Cognitive Decline
- Trial name
- NCT07416799
- Testing
- Progressive Exercise Program (12 Weeks)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cognitive Decline
Exercise Adherence and Cognitive Decline: Phase 2
The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community.
- Trial name
- MOVE (NCT07127965)
- Testing
- Goal Setting and Exercise Intensity Intervention
- Where
- 2 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Alzheimer Disease, Mild Cognitive Impairment
Study to Understand Novel Biomarkers in Researching Dementia
The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- SUNBIRD (NCT06547099)
- Testing
- Clinical tau PET, Clinical amyloid test, Research blood collection
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimer Disease, Periodontal Diseases
Investigation of Alzheimer's Disease and Periodontal Status
The aim of this study is to investigate the effect of the current periodontal status on the progression rate of AD.
- Trial name
- NCT05807100
- Testing
- Baseline Standardized Mini Mental Test, 6th month Standardized Mini Mental Test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bezmialem Vakif University
Cognitive Decline
Manipulating Cognitive Intensity During Aerobic Exercise
The purpose of this study is to investigate the performance effects of manipulating the properties of a cognitively engaging aerobic task.
- Trial name
- NCT06479265
- Testing
- Phyical/Cognitve Exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Mild Cognitive Impairment, Age-related Cognitive Decline
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious.
- Trial name
- NCT03528486
- Testing
- Music Training I
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy, Subjective Cognitive Decline (SCD)
Sleep Stimulation to Enhance Waste Clearance in the Brain
This study aims to examine whether multi-night closed-loop auditory stimulation (CLAS) during sleep can enhance waste clearance and memory consolidation in healthy adults and older adults with subjective cognitive decline or mild…
- Conditions
- Healthy, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
- Trial name
- NCT07051239
- Testing
- Closed-loop acoustic stimulation
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Delirium, Postoperative, Anesthesia
Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery
The goal of this clinical trial (Balanced-2 study) is to compare light to deep general anesthesia using widely available brain monitors, to see if 'light' anesthesia could reduce rates of delirium, cognitive decline, and…
- Conditions
- Delirium, Postoperative, Anesthesia, Surgery-Complications, Cognition Disorder
- Trial name
- Balanced-2 (NCT06268080)
- Testing
- Depth of anesthesia titration using pEEG
- Where
- 3 sites in New Zealand
- Volunteers
- 2,766 people
- Sponsor
- Auckland City Hospital
Healthy Volunteers
The Brain Alerting Mechanism Study
This is a study designed to look at how arousal levels in the brain change with age and how these changes influence thinking, vision, hearing and physical function in people of advanced age.
- Trial name
- NCT02050386
- Testing
- Cold pressor stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Decline
Effects of Multidomain Intervention on Cognitive Function in Community-dwelling Elderly
The aging population has contributed to an increase in cognitive decline. To mitigate the rise in the dementia population, it is crucial to prevent cognitive decline in older adults with normal functioning, subjective cognitive…
- Trial name
- NCT06180161
- Testing
- multidomain intervention
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Frail Elderly
Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults
The current study seeks to examine the prevalence of amyloid pathology, among patients referred to the Toulouse Geriatric Frailty Clinic presenting objective memory impairment.
- Trial name
- COGFRAIL (NCT03129269)
- Testing
- MRI and PET scan
- Where
- France
- Volunteers
- 344 people
- Sponsor
- University Hospital, Toulouse
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
MCI, Mild Cognitive Impairment (MCI)
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery.
- Conditions
- MCI, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment, Cognitive Deficit
- Trial name
- COGinREHAB (NCT07731334)
- Testing
- Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping
- Where
- 3 sites in Italy
- Volunteers
- 384 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Chewing Problem, Cognitive Decline
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
Today in elderly tooth loss and loss of oral function is widespread, but it is an underexplored modifiable risk factor potentially contributing to the development of dementia.
- Conditions
- Chewing Problem, Cognitive Decline, Magnetic Resonance Imaging, Degenerative; Dementia
- Trial name
- NCT04458207
- Testing
- Oral prosthetic rehabilitation
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Folktandvården Stockholms län AB
Memory Complaint Without Cognitive Decline
GAit, MEmory, Dietary and Vitamin D
Gait and posture disorders are very common in subjects aged 65 and over, and result mainly from neuromuscular and cognitive disorders.
- Trial name
- GAME-D2 (NCT02086409)
- Testing
- Yogurt supplemented with vitamin D and calcium, Yogurt not supplemented with vitamin D and calcium
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Cognitive Impairment, Dementia
Older Adults With Cognitive Impairment Doing Sit to Stands, Walking in Transitional Care Programs: A Feasibility Study
The goal of this intervention study is to test the effects of a nurse-led mobility intervention (known as the OASIS Walking Intervention (Older Adults performing Sit to Stands and Walking Intervention)) in older adults with…
- Conditions
- Cognitive Impairment, Dementia, Delirium, Functional Decline
- Trial name
- OASIS (NCT06150339)
- Testing
- OASIS Walking Intervention
- Where
- 2 sites in Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment and Psychopathology
Mild Cognitive Impairment (MCI) is a condition characterized by cognitive deterioration greater than what is expected from normal aging, representing an important risk factor for the development of dementia.
- Trial name
- MIND (NCT07358962)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health