Clinical trials: Cognitive Function Decline
Neurocognitive Disorders, Dementia
Care at 360º: A Long-term Individual Cognitive Stimulation Program
The aim of the intervention proposed in the present study is to assess the effect of a cognitive stimulation (CS) intervention program in an individual and long-term format, for non-institutionalized elderly people with…
- Conditions
- Neurocognitive Disorders, Dementia, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04417751
- Testing
- Cognitive Stimulation
- Where
- Portugal
- Volunteers
- 59 people
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Mild Cognitive Impairment, Subjective Cognitive Decline
Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age?
Memory and our own beliefs and confidence in our ability to remember are important for our daily lives. For example, low confidence may hold us back from doing certain tasks, whereas misplaced high confidence in our memories may…
- Trial name
- NCT06539403
- Testing
- Memory tasks
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- King's College London
Alzheimer Disease, Dementia
Predictors of Cognitive Decline in Normal Aging
The goal of this project is to develop an early diagnostic test for Alzheimer's disease (AD) by monitoring loss of neurons and brain size reductions over a period of five years.
- Trial name
- NCT00094939
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging, Sarcopenia
PANGeA - Physical Activity and Nutrition for Quality Ageing
General objectives of the project Defining healthy ageing factors; Setting up content-related bases of the international excellence centre (SLO-ITA) in the field of health of elderly citizens; Raising awareness on the…
- Conditions
- Aging, Sarcopenia, Cognitive Decline
- Trial name
- PANGeA_MM (NCT04899531)
- Testing
- Longitudinal observation
- Where
- Slovenia
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
COVID-19, Cognitive Decline
Study of Epidemiologic Investigation and Mechanism of Brain Network of Otologic and Cognitive Function With Post-COVID-19
The purpose of this study was to analysis the incidence of ear symptoms, cognitive function decline and emotional disorders in Chinese people who were infected with COVID-19, exploring the impact of COVID-19 on the auditory…
- Conditions
- COVID-19, Cognitive Decline, Otological Disease
- Trial name
- COVID-19 (NCT05787301)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Alzheimer Disease, Cognitive Impairment
Biomarker Exploration in Aging, Cognition and Neurodegeneration
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- BEACoN (NCT03860857)
- Testing
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cognitive Decline, Healthy Aging
Non-invasive Brain Stimulation and Strategic Memory Training
Physiological aging is often associated with memory function decline. Recently, the use of transcranial direct current stimulation (tDCS), a type of non-invasive brain stimulation, has been combined with adaptive working memory…
- Trial name
- StMe-tDCS (NCT05929872)
- Testing
- Non-invasive brain stimulation
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Urinary Incontinence, Urinary Tract Infections
Can the Use of Uricap Female Device Lead to Better Care for Women > 75+Years?
The purpose of the study is to evaluate if Uricap Female, an uridome for women, can be used instead of traditional incontinence aids to treat urinary incontinence (UI) among women 75 years and older.
- Conditions
- Urinary Incontinence, Urinary Tract Infections, Incontinence-associated Dermatitis, Cognition Disorders in Old Age
- Trial name
- U-PROTECT (NCT05275257)
- Testing
- Use of Uricap Female, a New Urine Collecting Device
- Where
- Sweden
- Sponsor
- Region Örebro County
Cognitive Decline
Clinical Application and Usability of Blood Biomarkers As Screening Tool in Alzheimer Disease: a Validation Study
Dementia caused by neurodegenerative diseases affects over 50 million people worldwide, Alzheimer's disease (AD) being the most common cause.
- Trial name
- BIOVALID-AD (NCT06699992)
- Testing
- Blood biomarkers quantification
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dementia, Cognition Disorders
Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation
Patients will be screened at Intermountain Medical Center and at Intermountain-affiliated anticoagulation clinics in the Salt Lake City region. Patients with non-valvular atrial fibrillation will be considered for study.
- Conditions
- Dementia, Cognition Disorders, Cerebral Ischemic Events
- Trial name
- CAF (NCT03061006)
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Intermountain Health Care, Inc.
Parkinson's Disease
Prevent Cognitive Decline in GBA-associated Parkinson's Disease
This is a proof-of-concept trial to investigate the efficacy of prasinezumab to slow or prevent cognitive decline in people with Parkinson's disease carrying a severe mutation in the GBA (glucocerebrosidase) gene.
- Trial name
- PreCoDe (NCT07055087)
- Testing
- Prasinezumab, Sodium Chloride
- Where
- 11 sites in France, Germany and 5 more
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Cognitive Decline, Mild, Alzheimer Disease
Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)
The goal of this placebo-controlled double-blind Phase 2 clinical trial is to test in people with early Alzheimer's Disease. The main questions it aims to answer are: Does treatment with fasudil, a ROCK-inhibitor, lead to…
- Trial name
- FEAD (NCT06362707)
- Testing
- Fasudil
- Where
- 6 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Helse Stavanger HF
Cognitive Decline, Heart Diseases
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery.
- Conditions
- Cognitive Decline, Heart Diseases, Delirium
- Trial name
- NCT03324867
- Testing
- Regular insulin, Normal Saline Flush, 0.9% Injectable Solution
- Volunteers
- 316 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Healthy
A Study Investigating the Effectiveness of a LifeSeasons NeuroQ Supplement With Lifestyle Changes to Improve Cognitive Function in Healthy Adults Who Have One or More Risk Factors for Cognitive Decline
The objective of this study is to evaluate the efficacy of a NeuroQ supplement designed by Dr. Bredesen to complement his Lifestyle modification protocol.
- Trial name
- NCT04149639
- Testing
- NeuroQ
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LifeSeasons Inc.
MCI, Mild Cognitive Impairment
Telehealth-Adapted Compensatory Training and Intervention for Cognition
The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention.
- Conditions
- MCI, Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
- Trial name
- TACTIC (NCT07366346)
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI), Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Mild Cognitive Impairment, Age-related Cognitive Decline
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious.
- Trial name
- NCT03528486
- Testing
- Music Training I
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Mild Cognitive Impairment, Mild Dementia
Gait, cOgnitiOn & Decline (GOOD)
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients…
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Moderate Dementia, Healthy
- Trial name
- NCT02350270
- Testing
- gait and cognitive testing
- Where
- France
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline.
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD)
- Trial name
- NCT07289061
- Testing
- Positive Psychology Intervention, Treatment as usual (TAU)
- Where
- Greece
- Volunteers
- 128 people
- Sponsor
- Aristotle University Of Thessaloniki