Clinical trials: Cognitive Functions
Alzheimer Disease, Down Syndrome
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS)…
- Conditions
- Alzheimer Disease, Down Syndrome, Mild Cognitive Impairment
- Trial name
- NCT02612376
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Impairment
Walking Interventions, Cognitive Remediation and Mild Cognitive Impairment
The purpose of this study is to determine the effects of a coordinated intervention of cognitive remediation training (CRT) and walking intervention on cognition and gait in the elderly.
- Trial name
- WalkCog-MCI (NCT01801943)
- Testing
- Cognitive Remediation Therapy Group, Walking Intervention (WI) Group, Combination Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Exercise, Anxiety
The Effect of Exercise on Anxiety and Cognition in Students at University
RATIONALE: Exercise may improve the mood and cognition in young people. PURPOSE: It has been well-known that physical exercise can generally benefit the mental health.
- Conditions
- Exercise, Anxiety, Depression, Cognition
- Trial name
- NCT04847128
- Testing
- Chronic aerobic exercise
- Where
- China
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Family Caregiving, Infant Health
The Effect of Family-Integrated Care Model on Infant and Toddler Health Promotion
The FIC model effectively promotes infant growth, improves nutrition, reduces disease risk, and supports early cognitive and psychological development while enhancing parental caregiving skills, demonstrating strong clinical…
- Conditions
- Family Caregiving, Infant Health, Growth, Nutrition
- Trial name
- NCT06933316
- Testing
- the intervention group, the control group
- Where
- China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Xiaoqi Lin
Cognitive Function, Neuroplasticity
How Cultural Background Affects Cognitive and Motor Learning Using Virtual Reality
This observational study examined how long-term cultural background is associated with differences in cognitive and motor learning within a virtual reality environment.
- Conditions
- Cognitive Function, Neuroplasticity, Motor Skills, Virtual Reality
- Trial name
- NCT07242937
- Testing
- Virtual reality beat saber training and cognitive and motor assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Cognition - Other, Strength Outcomes
Effects of Alpha-GPC on Muscle Power, GH Levels, and Cognitive Function
Purpose: To determine the effects of low dose and high dose Alpha-GPC on cognitive performance, muscle performance, and serum growth hormone levels.
- Trial name
- NCT06690619
- Testing
- 315 mg Alpha-GPC, 630 mg Alpha-GPC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Cognitive Decline
Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive…
- Trial name
- NCT05016336
- Testing
- Social interaction combined with cognitive training based on mnemonic strategies., Social interaction group
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Healthy, Non-Smoking
Evaluation of Varenicline Safety, Tolerability, Pharmacokinetics and Pro-Cognitive Effects in Healthy Elderly Non-Smoking Subjects
1. Characterize the tolerability and safety of repeated doses of varenicline in healthy non-smoking elderly subjects. 2. Describe the steady state pharmacokinetics of varenicline in healthy non-smoking elderly subjects. 3.
- Trial name
- NCT00694044
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Individuality
Effects of Hydrocortisone on Social Cognition and Memory
The effects of hydrocortisone on cognition will be investigated.
- Trial name
- CORT-COG (NCT02478021)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cognitive Performance, Memory
Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive…
- Conditions
- Cognitive Performance, Memory, Mood, Anxiety
- Trial name
- NCT05541887
- Testing
- Muscadine Wine Polyphenol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognition, Brain Volume Loss
Effect of Fingolimod on Neurodegeneration
This was a 24-month, open-label, multicenter study with a single treatment arm design. Primary objective of this study was: -To investigate the effects of Fingolimod on cognitive performance in highly active relapsing remitting…
- Trial name
- NCT02575365
- Testing
- 0,5 mg Fingolimod
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Schizophrenia, Autism Spectrum Disorder
A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia
This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data…
- Trial name
- NCT07618767
- Where
- Taiwan
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cognition, Sedentary Behaviors
Sedentary Activities and Passive-to-Intense Effects on Neuro-Cognitive States
Prolonged sedentary behavior is linked to poorer metabolic health, yet its effect on cognitive load and brain function remains unclear.
- Trial name
- SAPIENS (NCT07087236)
- Testing
- Maximum Cognitive Load, Mental active/pasive activities, Baseline Cognitive Load
- Where
- Chile
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Valparaiso
Mild Cognitive Impairment
Cognitive Brain Training in Older Adults
The investigators will conduct a 8-week proof-of-concept randomized controlled trial to provide preliminary evidence of efficacy of Fit Brains (Rosetta Stone Canada) training -- a mobile cognitive training program -- on cognitive…
- Trial name
- NCT02564809
- Testing
- Fit Brains Training, Exercise + Fit Brains Training, Balanced And Tone
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Cognitive Impairment (MCI)
Cognitive-Frailty Gait Biomechanics for Early Dementia Detection
The purpose of this study is to better understand how physical characteristics, walking patterns, and a blood-based brain health marker differ between older adults with dementia and healthy older adults.
- Trial name
- gait dementia (NCT07448909)
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Cognitive Decline, Focus Deficit
Effects of Auri Super Mushroom Daily Gummies on Cognitive Health
This is a single-arm, open-label, virtual clinical trial evaluating the cognitive health effects of Auri Super Mushroom Daily Gummies in a population of 35 adult participants over 8 weeks.
- Trial name
- NCT07198399
- Testing
- Auri Super Mushroom Daily Gummies
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Auri Nutrition
Cognitive Enhancement During Exercise
Effect of Huperzine A on Cognitive Function and Perception of Effort During Exercise
This study evaluates the effects of acute huperzine A ingestion prior to exercise on cognitive function and perceived effort in exercise-trained individuals.
- Trial name
- NCT03445104
- Testing
- Huperzine A
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Weight Loss, Bone Density
Metabolic Health, Bones and Nuts During Weight Loss in Adults
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group.
- Conditions
- Weight Loss, Bone Density, Obesity and Overweight
- Trial name
- BERN (NCT06949280)
- Testing
- Peanut Snack Experimental, Nut-free Snack
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey