Clinical trials: Cognitive and Executive Dysfunction
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
TBI, Cognitive Dysfunction
Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond
For many Veterans, success in achieving goals at work, school and in other aspects of life are top priorities. The abilities to regulate attention, remember key information, and stay calm and on track are fundamental to this…
- Trial name
- NCT04109027
- Testing
- BrainStrong-BSR, BrainStrong-OPT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Depression
Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults
This study will evaluate the efficacy of Problem Adaptation Therapy (PATH) vs. Supportive Therapy for Cognitively Impaired (ST-CI) older adults in reducing depression and disability in treating depressed, cognitively impaired…
- Trial name
- NCT00368940
- Testing
- PATH, ST-CI
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Alcohol Dependence, Bipolar Disorder
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
The study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their…
- Conditions
- Alcohol Dependence, Bipolar Disorder, Depression, Mania
- Trial name
- NCT01015586
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Aging, Physical Activity
Exercise Periodization and Older Adults
The present study aimed at investigating the effects of two different resistance training protocols - nonperiodized (NP) and daily undulating periodization (DUP) - on hemodynamic, morphofunctional and cognitive parameters of…
- Conditions
- Aging, Physical Activity, Sarcopenia, Cognitive Decline
- Trial name
- NCT03443375
- Testing
- Physical exercise
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Stroke, Executive Dysfunction
Computerized Cognitive Rehabilitation of Executive Deficits in Stroke Patients
WHO: 32 participants with executive deficits related to a stroke, able to engage in moderate physical activity. WHY: Around one third of stroke patients suffer from cognitive deficits in the long term, which have a detrimental…
- Trial name
- NCT05169632
- Testing
- Computerized Gaming Rehabilitation Program 1, Computerized Gaming Rehabilitation Program 2
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
TBI (Traumatic Brain Injury), Brain Injuries
Brain Markers of Improvements in Cognitive Functioning
Some of the most common, persistent, and disabling consequences of traumatic brain injury affect an individual's ability to achieve personal goals.
- Conditions
- TBI (Traumatic Brain Injury), Brain Injuries, Stress, Attention Deficit
- Trial name
- NCT03490110
- Testing
- State regulation skill training, Treatment-as-usual
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Falls, Fall Risk
The Relationship Between Self-Awareness and Risk of Falls During Walking in Adults
This study examines the relationship between self-awareness and the risk of falls during walking in older adults and rehabilitation patients. Falls are a major health concern among older adults worldwide.
- Conditions
- Falls, Fall Risk, Fall Risk Factors, Cognitive Dysfunction
- Trial name
- SAFR (NCT07367763)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Older Adults, Cognitive Impairment, Mild
Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment
This pilot study investigates the effects of a music-based dance intervention on executive function and physical performance in middle-aged and older adults with cognitive impairment.
- Trial name
- NCT07105800
- Testing
- Music-based dance, Control
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Lymphoblastic Leukemia
Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia
A common and potentially debilitating late effect of childhood cancer treatment is neurocognitive impairment, frequently in the domain of executive dysfunction, which can limit educational attainment, employment, and quality of…
- Trial name
- NCT02336282
- Testing
- transcranial Direct Current Stimulation (tDCS), Cognitive Assessment, Brain Games Stimulation
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- St. Jude Children's Research Hospital
Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular)
Symptomatic Treatment of Vascular Cognitive Impairment
Single center threeway double blind cross over trial investigating the pharmacological responsivity in patients with VCI using a challenge aimed at the monoaminergic and cholinergic neuronal systems
- Conditions
- Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular), Vascular Dementia
- Trial name
- STREAM-VCI (NCT02098824)
- Testing
- Galantamine, Methylphenidate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Cognitive Impairment
Compensatory and Restorative Rehabilitation Techniques in Stroke
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
- Trial name
- NCT06325085
- Testing
- compensatory and restorative rehabilitation techniques, Traditional cognitive rehabilitation training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Cognitive Decline, Dementia
Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults.
- Conditions
- Cognitive Decline, Dementia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT01264614
- Testing
- Strengthening exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Multiple Sclerosis
Study of Exercise on Impact of Cognitive Functioning in Multiple Sclerosis Patients
Cognitive impairment affects roughly 50% of people with multiple sclerosis (MS). There are currently no satisfactory medical treatments for cognitive impairments related to MS and alternative forms of treatment are needed.
- Trial name
- NCT02106052
- Testing
- Aerobic exercise, Stretching and toning exercise
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington
Accidental Falls, Aging
Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
The goal of this interventional study is to compare in community dwelling elderly people the effects of two physical activity programs to prevent accident falls : "SILVER XIII EQUILIBRE" program and "VIVIFRAIL" program, on…
- Conditions
- Accidental Falls, Aging, Mild Cognitive Impairment
- Trial name
- 13EVAL (NCT05625828)
- Testing
- Cognitive-motor Physical Activity, Multifactorial Physical Activity
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Postoperative Cognitive Dysfunction
Effect of Sedation on Cognitive Performance in the Elderly
The main goal of this study is to allow the anesthesiologist to make a more informed decision about the anesthetic requirement of a person prior to starting anesthesia.
- Trial name
- NCT03089866
- Testing
- Midazolam (0.02mg/kg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University