Clinical trials: Cohort
Multiple Sclerosis
Multiple Sclerosis: FutureMS-2 - an Observational Cohort and Scottish Precision Medicine Study
FutureMS is a project created in direct response to frequent questions people with MS ask their doctors. Every person newly diagnosed wants to know how MS will affect them over their life and what can be done to stop the disease…
- Trial name
- NCT06001138
- Where
- 5 sites in United Kingdom
- Volunteers
- 440 people
- Sponsor
- University of Edinburgh
Healthy
Evaluation of Pharmacokinetic Drug Drug Interaction Between PF-05221304 And PF-06865571 In Healthy Adult Subjects
Drug drug interaction study between PF-05221304 and PF-06865571
- Trial name
- NCT03534648
- Testing
- PF-06865571 administered Day 7-14, PF-06865571 administered Day 1-14, PF-05221304 administered Day 1-14
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Mental Health, Neurodevelomental Disorders
Mental Health and Innovation for French Higher-education Students
To fully grasp mental health, it is essential to understand and assess it by considering all the factors that affect it: family environment, school environment, emotional relationships, living conditions, social networks, etc.
- Trial name
- SMILE (NCT07800585)
- Where
- France
- Volunteers
- 13,710 people, healthy volunteers welcome
- Sponsor
- O-Kidia
Atherosclerotic Cardiovascular Disease
A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Netherlands)
This study will evaluate cardiovascular outcomes among individuals with clinically established atherosclerotic cardiovascular disease (ASCVD) who have not previously experienced a myocardial infarction (MI) or ischemic stroke.
- Trial name
- NCT07905508
- Where
- Netherlands
- Volunteers
- 180,000 people
- Sponsor
- Sanofi
Pancreas Cancer
Prospective Cohort Study of Pancreatic Cancer Patients Treated With Proton Beam Therapy
Pancreatic cancer is one of the few cancers whose survival rate has not improved significantly due to high local recurrence and systemic metastasis despite advances in diagnosis and treatment over the past 40 years.
- Trial name
- NCT04466189
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- National Cancer Center, Korea
Anesthesia, Child
Evaluation of the Pediatric Igel Airway in 250 Children
Once a child has been anaesthetised and is fully asleep, a special airway tube called a laryngeal mask is often inserted into their mouth to help with their breathing. This tube is removed just before the child wakes up.
- Conditions
- Anesthesia, Child, Infant
- Trial name
- NCT00969189
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
AKI
Preadmission Metformin Exposure and Incidence of Acute Kidney Injury
More than 50% of ICU patients suffer from Acute kidney injury (AKI). Metformin shows protective properties in kidney disease. Our study aimed to validate AKI incidence among diabetes patients in the ICU with or without…
- Trial name
- NCT04631289
- Where
- China
- Volunteers
- 3,841 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Asthma, Wheeze
Pediatric Arm of DZL All Age Asthma Cohort
Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood.
- Conditions
- Asthma, Wheeze, Hypersensitivity, Endophenotype
- Trial name
- ALLIANCE (NCT02496468)
- Where
- 5 sites in Germany
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Age-related Cataract
Metabo-lipidomics of the Ocular Surface for Cataract Surgery
Cataract is the world's leading cause of blindness, the treatment of which, exclusively surgical, offers excellent results in terms of visual recovery.
- Trial name
- CATARACTOMIQUE (NCT05802550)
- Testing
- Ocular Surface Disease Index, Interferometry, Oxford score
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Safety, Tolerability
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants
The purpose of this study is to evaluate the safety and tolerability of single and multiple oral dosing of MLN3126 in ascending doses in healthy non-Japanese and Japanese participants.
- Conditions
- Safety, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT02209506
- Testing
- MLN3126
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Takeda
Choledochal Cyst
Efficacy and Safety of Surgical Treatment for Type IVa CBD
This study is a multicenter, bidirectional cohort study aimed at continuously enrolling patients with biliary dilatation from 25 medical centers in China.
- Trial name
- NCT07036848
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Schizophrenia
The Effect of Long-acting Antipsychotics on Schizophrenia Patients With Violence Risk
This is a 49 weeks prospective, non-interventional cohort study. To observe the effect of long-acting injection antipsychotic(LAI), paliperidone palmitate on prevention of recurrence and symptom control in schizophrenia patients…
- Trial name
- NCT04064476
- Testing
- Paliperidone Palmitate
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Huazhong University of Science and Technology
Hepatitis C Infection, HIV
HCV-HIV Co-infected Patient Cohort in Thailand
This is a study of HCV treatment using the standard regimen of pegylated-interferon plus ribavirin in HIV co-infected patients participating in the PHPT cohort study.
- Trial name
- NCT02247440
- Testing
- Peg-interferon + ribavirin under HIV physician supervision
- Where
- 5 sites in Thailand
- Volunteers
- 18 people
- Sponsor
- Institut de Recherche pour le Developpement
Alzheimer's Dementia
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)
Brain changes associated with Alzheimer's disease may precede symptoms of Alzheimer's Dementia by over 20 years. The Investigators hope to be able to identify Alzheimer's disease at its very earliest stages when in theory…
- Trial name
- EPAD-LCS (NCT02804789)
- Where
- 30 sites in Belgium, France and 7 more
- Volunteers
- 2,095 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Hypertension, Type 2 Diabetes
A Cohort Study of Morning Home Blood Pressure Measurement in Type 2 Diabetic Patients
Previous cross-sectional studies have demonstrated that blood pressure (BP) measurements at home (HBP) in the morning offer stronger predictive power for micro- and macrovascular complications in patients with type 1 and 2…
- Trial name
- NCT00760110
- Testing
- blood pressure measurements based on HBP or CBP
- Volunteers
- 400 people
- Sponsor
- Nagaoka Red Cross Hospital
Lipodystrophy, Dunnigan Syndrome
Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy
The objective of this work is to identify biomarkers of interest in patients with insulin resistance leading to early disorders of glycemic regulation.
- Trial name
- IRAP-DUN 2 (NCT05424913)
- Testing
- research-specific blood sample
- Where
- Reunion
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Atrioventricular Block, Progressive Cardiac Conduction Defect
Cohort Description of Younger With AV-block
Background: Disturbances of the heart's atrioventricular conduction - AV-block - may show by shortness of breath, fainting or sudden death. If AV-block is diagnosed in time pacemaker therapy may be lifesaving.
- Conditions
- Atrioventricular Block, Progressive Cardiac Conduction Defect, Genetic Disease
- Trial name
- NCT03024047
- Testing
- Pacemaker
- Where
- Denmark
- Volunteers
- 1,255 people
- Sponsor
- University of Aarhus
Intraoperative Hypotension
A Comparative Study Protocol Investigating the Association Between Intraoperative Hypotension and the Use of Ring- Versus Propofol-Based Anesthesia in Elderly Patients Undergoing Non-Cardiac Surgery
we conducted this multicentre retrospective cohort study to evaluate the association between the choice of induction agent (ciprofol versus propofol) and the incidence of IOH in geriatric patients having non-cardiac surgery.
- Trial name
- NCT07808125
- Where
- China
- Volunteers
- 85,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Symptomatic Aortic Stenosis
ACURATE TF™ Transfemoral Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis:CE-approval Cohort
First clinical experience on the ACURATE TF™ Transfemoral Aortic Bioprosthesis Implantation in Patients with Severe Aortic Stenosis to collect human data pertaining to the safety and performance of the device from three different…
- Trial name
- NCT03003650
- Testing
- ACURATE TF™
- Where
- 6 sites in Brazil, Germany and 1 more
- Volunteers
- 89 people
- Sponsor
- Symetis SA
Asthma in Children, Protracted Bacterial Bronchitis
Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity Evaluation
The goal of this observational study is to improve the identification of biomarkers that predict disease progression and to assess the effectiveness of current therapies in children with asthma and protracted bacterial…
- Conditions
- Asthma in Children, Protracted Bacterial Bronchitis, Chronic Cough
- Trial name
- BRONCHOSCOPE (NCT07232550)
- Testing
- fiberoptic bronchoscopy, blood sample collection, Respiratory functional tests
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Medical University of Warsaw
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