Clinical trials: Cohort
Severe Asthma, COPD
K-HEALTH in AIR - Barcelona Pilot - Cohort
The study protocol is part of the European (EU) project "Knowledge for improving indoor AIR quality and HEALTH" (K-HEALTHinAIR, 2022-2026 - registry 101057693), which focuses on enhancing our understanding of how poor indoor air…
- Trial name
- NCT06421402
- Testing
- Air quality monitoring at patient's home, Questionnaires: Baseline & every six months, Lung function Testing: Baseline & every six months & during exacerbations
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Volume Outcome Relationship Among COVID-19 Inpatients in US Hospitals
Hospital COVID-19 Surge and Associated Mortality Risk
A retrospective cohort study will be conducted using a large administrative database of U.S. hospitals to understand the volume-outcome relationship among patients hospitalized with COVID-19.
- Trial name
- NCT04688372
- Testing
- Surge Index
- Where
- United States
- Volunteers
- 144,116 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Spinal Cord Injuries
Spinal Cord Injury Program in Exercise
The purpose of this study is to examine two 8-week, remotely delivered exercise interventions: Movement-to-Music (M2M) and Standard Exercise Training (SET), with 327 adults with spinal cord injury.
- Trial name
- SCIPE (NCT03925077)
- Testing
- Movement-to-Music, Standard Exercise Training
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Alabama at Birmingham
Advanced Pancreatic Cancer, Metastatic Pancreatic Cancer
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma
Laboratory studies suggest that the study drug may stop cancer cells from growing by affecting an interaction between proteins in the cells referred to as cAMP-response element-binding protein and ß-catenin.
- Conditions
- Advanced Pancreatic Cancer, Metastatic Pancreatic Cancer, Pancreatic Adenocarcinoma
- Trial name
- NCT01764477
- Testing
- PRI-724
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Prism Pharma Co., Ltd.
Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer
Research on Effective Strategies After Immunotherapy for Mismatch Repair-deficient Early-stage GI Tumors
This cohort study is divided into two parts: Part A: Registry Cohort All patients with non-metastatic, MMRd/MSI-H colorectal cancers (and other gastrointestinal cancers for exploratory analysis) who have signed the general…
- Conditions
- Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer, Microsatellite Instability-High Colorectal Cancer, Stage II Colorectal Cancer
- Trial name
- RESIST (NCT07829081)
- Testing
- Active surveillance after complete response to immunotherapy in MMRd GI cancers, Stand of Care
- Where
- 3 sites in Switzerland
- Volunteers
- 234 people
- Sponsor
- University Hospital, Basel, Switzerland
Hemophilia A and B, Liver Transplantation
ATHN 11: Liver Transplantation Outcomes Study
This study is designed as a multi-center, observational cohort study of participants with hemophilia A and B who have and have not undergone liver transplantation.
- Trial name
- HOT (NCT04055051)
- Where
- 15 sites in United States
- Volunteers
- 86 people
- Sponsor
- American Thrombosis and Hemostasis Network
Atopic Dermatitis
Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.
- Trial name
- NCT05790330
- Testing
- Methotrexate, Dupilumab
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- King's College London
Crohn Disease, Recurrence
Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.
The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first…
- Conditions
- Crohn Disease, Recurrence, Crohn's Ileocolitis
- Trial name
- NCT04539665
- Testing
- Extended mesenteric resection.
- Where
- 2 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Montreal General Hospital
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
COVID-19, Bacterial Infections
Incidence of Colonization by Multidrug-resistant Organisms in Mechanically Ventilated Patients With Severe COVID-19
Retrospective single-center cohort study to evaluate the incidence of colonization by multidrug-resistant organisms (MDRO) in mechanically ventilated patients admitted to a large intensive care unit (ICU) for severe acute…
- Conditions
- COVID-19, Bacterial Infections, Colonization, Asymptomatic
- Trial name
- MDR_in_Fiera (NCT05293418)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 435 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pulmonary Embolism, Venous Thrombosis
Incidence of Venous Thromboembolic Disease and Portal Vein Thrombosis After Hepatectomy. A Cohort Study.
Observational. Retrospective cohort.
- Conditions
- Pulmonary Embolism, Venous Thrombosis, Portal Thrombosis
- Trial name
- NCT02597218
- Where
- Argentina
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Encephalopathy
A Multi-Center Cohort Study of Risk Factors and Outcomes of Encephalopathy of Prematurity in China
The purpose of this study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age <32 weeks in China.
- Trial name
- NCT02831010
- Where
- 14 sites in China
- Volunteers
- 761 people
- Sponsor
- Children's Hospital of Fudan University
Chronic Hepatitis B, Hepatic Fibrosis
Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD
Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C.
- Conditions
- Chronic Hepatitis B, Hepatic Fibrosis, Fatty Liver
- Trial name
- NCT02031913
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Boramae Hospital
Hemorrhage
Hemostasis Achievement Reflecting Inflammatory Status of the Pulp Based on Cytokine Levels: A Cohort Study.
Assessment of pulp inflammation by hemostasis achievement after pulp exposure
- Trial name
- NCT03737682
- Testing
- ENzyme linked immunity-sorbet assays
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Cairo University
HR Positive HER2 Negative Advanced Breast Cancer
Different Doses of Dalpicicl Combined With Letrozole in the First-line Treatment of HR-positive, HER2-negative Advanced Breast Cancer
This study is a prospective, open-label, randomized, multicenter, two-cohort phase II clinical trial. Starting from December 1, 2024, it plans to enroll 120 patients with advanced first-line HR-positive, HER2-negative breast…
- Trial name
- NCT07285382
- Testing
- Dalpiciclib 125mg, Dalpiciclib 150mg, Letrozole 2.5mg
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- wanghaibo
Burn Injury, Burns
Foreign-National Burn Patients in a Border-Region Burn Center
This retrospective cohort study will evaluate burn patients hospitalized and treated at the Burn Center of Gaziantep City Hospital between October 2023 and June 2026.
- Trial name
- NCT07673796
- Volunteers
- 1,400 people
- Sponsor
- Gaziantep City Hospital
Advanced Lung Cancer, Ovarian Cancer
Clinical Study of AL2846 Capsules in the Treatment of Advanced Lung Tumor and Advanced Ovarian Cancer
This is a multi-cohort, randomized, open, multicenter Phase II study to evaluate the efficacy and safety of AL2846 capsules in patients with advanced lung cancer and ovarian cancer.
- Trial name
- NCT05815862
- Testing
- AL2846 capsule
- Where
- 4 sites in China
- Volunteers
- 29 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Progressive Multifocal Leukoencephalopathy, Immune Checkpoint Inhibitors
Observational Cohort Study of Chronic Viral Infection in the Central Nervous System
This research team intends to conduct a real-world cohort study of chronic CNS viral infections represented by PML, to evaluate whether administration of immune checkpoint inhibitors improves long-term outcomes in this patient…
- Trial name
- NCT07512518
- Testing
- Immune Checkpoint Inhibitors
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking Union Medical College Hospital
Hepatitis C Virus Infection
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination +/- Ribavirin in Adolescents and Children With Chronic HCV-Infection
The primary objective of the PK Lead-in Phase of the study is to evaluate the steady state pharmacokinetics (PK) and confirm the dose of ledipasvir/sofosbuvir (LDV/SOF) fixed dose combination (FDC) in hepatitis C virus…
- Trial name
- NCT02249182
- Testing
- LDV/SOF, RBV
- Where
- 31 sites in United States, Australia and 2 more
- Volunteers
- 226 people
- Sponsor
- Gilead Sciences
Preoperative Anxiety
Impact of Premedication on Anxiety
IMPACT aims to evaluate the clinical routine practice of premedication in German hospitals and to estimate the influence of premedication on anxiety reduction.
- Trial name
- Impact (NCT04103723)
- Testing
- Preoperative premedication
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- RWTH Aachen University
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