Clinical trials: Cold
Prehypertension
Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.
- Trial name
- NCT06428890
- Testing
- Grape Seed Extract
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Common Cold, Respiratory Tract Infections
The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold
A randomized parallel-group two arm superiority trial with an allocation ratio 1:1, both participants and investigators blinded.
- Trial name
- HelZinki (NCT03309995)
- Testing
- Lozenges
- Where
- Finland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Dexmedetomidine, Adenotonsillectomy
Intranasal Dexmedetomidine in Children Undergoing Adenotonsillectomy Suffering From Mild Upper Respiratory Tract Infection
The purpose of this study is to detect the efficacy of intranasal dexmedetomidine as a premedication to general anesthesia in pediatric patients with respiratory comorbidities undergoing adenotonsillectomy.
- Conditions
- Dexmedetomidine, Adenotonsillectomy, Respiratory Tract Infections
- Trial name
- NCT05639777
- Testing
- Dexmedetomidine group, control group
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tanta University
RSV Infections, RSV Immunisation
A Clinical Trial on Safety in Pregnant Women and How Well the Infant is Protected Against RSV-associated Lower Respiratory Tract Infection When the Pregnant Woman Receives the Approved RSV Vaccine Compared to a Placebo.
Respiratory syncytial virus (RSV) is a virus that often affects children during childhood. Even though most cases of RSV are mild, it can cause serious disease and even death - especially in very young babies, babies born too…
- Conditions
- RSV Infections, RSV Immunisation, Preterm Labour
- Trial name
- NCT06955728
- Testing
- Vaccine
- Where
- 11 sites in Ghana, Kenya and 2 more
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Analgesia
Breath Metabolomics of Placebo Effects, a Pilot Study
This study is to analyze the breath metabolome before and after the administration of a placebo in an established experimental pain procedure in healthy subjects in order to investigate placebo effects, and whether they induce…
- Trial name
- BMPE (NCT04956718)
- Testing
- Cold Pressor Test (CPT)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Viral Upper Respiratory Tract Infection
ARMS-I (a Formulation of Cetylpyridinium Chloride -CPC)
This is a single center study to evaluate the pharmacokinetics of ARMS-I a formulation that incorporates cetylpyridinium chloride (CPC), administered once as a single dose of three sprays orally, followed by multiple dosing (3x…
- Trial name
- ARMS-I (NCT03026205)
- Testing
- ARMS-I
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Croup
Impact of Cold Air Exposure on Croup Symptoms
The goal of the present randomised controlled clinical trial is to compare the efficacy of a 30-minute exposition to cold, atmospheric, outdoor air on the severity of croup symptoms with exposition to indoor room air in children…
- Trial name
- NCT05668364
- Testing
- Outdoor cold air exposure
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Nutritional Supplementation, Exercise Physiology
Green Tea Extract and Ginger
This study investigates the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolism, thermal comfort, and muscle soreness in recreationally active young…
- Trial name
- Thermal effect (NCT07150533)
- Testing
- Green Tea Extract, Ginger, Combined Supplement (Green Tea + Ginger)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Erzurum Technical University
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
COVID-19, Vaccine-Preventable Diseases
The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection
The purpose of this research study is to find out how well two different 2023-2024 updated COVID-19 vaccines protect people from COVID-19 (the disease caused by the SARS-CoV-2 virus), and to determine if getting a 2023-2024…
- Conditions
- COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection, Upper Respiratory Tract Infection
- Trial name
- BEEHIVE (NCT06065176)
- Testing
- Novavax COVID-19 vaccine (2023-2024 formula XBB containing), Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
- Where
- United States
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Sarang K. Yoon, DO, MOH
Recovery, Physiological, Athletic Performance
The Effect of Cold Water Immersion on Recovery and Performance in NCAA Division I Athletes
In this study, the investigators will examine the effect of cold-water immersion (CWI) on objective and subjective recovery metrics, as well as simple performance metrics, in National Collegiate Athletics Association (NCAA)…
- Trial name
- NCT06565468
- Testing
- Cold water immersion pool.
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Eating Habit, Cold Exposure
Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake
Military personnel and athletes have a very high energy expenditure which is increased during certain key periods (intense training, competition and mission).
- Conditions
- Eating Habit, Cold Exposure, Heat
- Trial name
- TEMPCA (NCT05584527)
- Testing
- Heat exposure (32°C), Cold exposure (16°C), Thermoneutral exposure (24°C)
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Appetite
Assessment of the Effects of Acute Exposure to Cold and Heat on Appetite
Military personnel and athletes have a very high energy expenditure, which is increased during certain key periods (intense training, competition and missions).
- Trial name
- TEMPCA2 (NCT06809296)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Healthy
Trial to Assess Safety, Tolerability, and Immunogenicity of Influenza Virus Vaccine, Trivalent, Types A and B, Live Cold-adapted (CAIV-T) in Healthy Children
The study was designed to determine the number of doses of CAIV-T required to effectively immunize children and adolescents in the 6 to 17 year age group.
- Trial name
- FluMist (NCT00192270)
- Testing
- CAIV-T
- Where
- 3 sites in Belgium, Finland
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Pain, Fear
The Effect of Buzzy and Puppet on Pain and Fear
Summary Aim: This study was conducted to evaluate the effects of the use of Bee Buzzy, external vibrating cold application, and the use of puppets on pain and fear in children aged 3 to 6 years during phlebotomy.
- Conditions
- Pain, Fear, Nurse's Role
- Trial name
- NCT05827783
- Testing
- Implementation of Bee Buzzy, Implementation of Puppet Zuzu
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ege University
Procedural Anxiety, Fear
Effects of Virtual Reality, Cold-Vibration Due To Intravenous Catheterization on Pain, Fear and Anxiety on Children
This is a randomized controlled trial. The aim of the study is to the effects of Virtual Reality and Local Cold-Vibration applications in reducing anxiety, fear and pain due to intravenous catheterization (PIC) in children aged…
- Conditions
- Procedural Anxiety, Fear, Procedural Pain, Child, Only
- Trial name
- NCT05435105
- Testing
- Virtual reality, Local cold-vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Healthy
Effect of a 16-day Hot and Cold Acclimation on Adaptive Responses and Health-related Indicators
There are no previous studies of the effects of a combination of whole-body immersions in hot and cold baths on adaptive responses and health-related markers.
- Trial name
- NCT06346639
- Testing
- 16-day hot and cold acclimation
- Where
- Lithuania
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Tetanus, Tetanus Vaccine
Comparative Study of Two Tetanus Toxoid Vaccination Strategies: Cold Chain Versus Controlled Temperature Chain
The purpose of this study is to determine the effectiveness, safety and feasibility of a tetanus toxoid (TT) vaccination strategy relying on the maintenance of vaccines in a controlled temperature chain (CTC).
- Trial name
- NCT01559597
- Testing
- Tetanus toxoid vaccine
- Where
- Chad
- Volunteers
- 2,129 people, healthy volunteers welcome
- Sponsor
- Epicentre
Blood Pressure, Arrhythmias
Hemodynamic Effects of Dry Sauna Followed by Cold Water Immersion in Healthy Subjects
The purpose of this study is to determine the safety on sauna followed by cold water bath, a common practice in many countries, 30 healthy subjects aged 40 years and older will be at the Montreal Heart Institute Prevention and…
- Trial name
- NCT02598258
- Testing
- Sauna and cold water bath
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Healthy
The Effects of Manual Lymphatic Drainage on the Autonomic Nerve System
Forty healthy women who met the inclusion criteria were included in the study. In the single-blind randomized controlled study, the participants were divided into 3 groups manual lymphatic drainage(MLD), sham MLD, and control…
- Trial name
- NCT05809726
- Testing
- Manual lymph drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University