Clinical trials: Cold Exposure
Healthy, Blood Pressure
The Effectiveness of the Wim Hof Method
The Wim Hof Method is a multi-disciplinary approach to physical and mental well-being combining cold exposure, breathing exercises, and meditation.
- Conditions
- Healthy, Blood Pressure, Cold Exposure, Stress
- Trial name
- NCT05894031
- Testing
- Wim Hof Method
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cognitive Function
Acute Effects of Cold Exposure on Cognitive Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
- Trial name
- NCT06654167
- Testing
- Low temperature (15℃) group, Moderate temperature (22℃) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Healthy
Inuit and Cold Exposure
Brown adipose tissue (BAT) produces heat through non-shivering thermogenesis. It is activated by cold exposure, and when activated it utilizes fatty acids and glucose in order to produce heat.
- Trial name
- ICE (NCT05884177)
- Testing
- Short-term cold exposure
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stig Andersen
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Cold Exposure
Oxytocin on Cold Water Task Performance and Recovery
Naval Special Warfare (NSW) operators are exposed to a variety of extreme environmental conditions and intense physical demands.
- Trial name
- NCT04738838
- Testing
- Oxytocin nasal spray
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Healthy
The Effect of Exposure to Aversive Non-verbal Vocalizations on Pain Tolerance
Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues.
- Trial name
- CRYPAIN (NCT04423874)
- Testing
- Cold pressor task (CPT), index NOL, Playback Experiments
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension
L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia
Cardiovascular disease (CVD) continues to be the major cause of morbidity and mortality in western countries. It has been shown that CVD events are known to be higher in the winter than in the summer.
- Trial name
- NCT02104375
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy
Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air
We hypothesize that continuous positive pressure applied to the airway will decrease the ability of the nose to warm and humidify inspired air compared to zero or negative pressure.
- Trial name
- NCT00338403
- Testing
- Continuous positive airway pressure (CPAP) at -5, 0, 5 and 10 cm of water
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Behavior, Stress
Cold Water and Decision-Making
The behavioral within-subject cross-over design study "CoVa" aims to investigate the effect of a short-term full-body cold-water immersion vs.
- Conditions
- Behavior, Stress, Quality of Life, Psychological Wellbeing
- Trial name
- CoVa (NCT06908447)
- Testing
- Cold-water immersion, Warm-water immersion (Control)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Particularly Partial-body Cryostimulation
Effect of Cryostimulation on Selected Motor Skills in Soccer Players
A randomized study was conducted during two training periods. The first stage of a 5-day cryostimulation procedure took place in November 2022, during the training period after the end of the league season.
- Trial name
- NCT06812819
- Testing
- Cryostimulation is a form of cooling the body using low temperatures without causing tissue damage. The stimulus effect is achieved at temperatures below - 110⁰C, in a short time of 1-3 minutes. The p
- Where
- Poland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Cold Exposure, Hyperventilation
Effects of Cold Exposure and Breathing Techniques on Immune Response
Inflammatory cytokines play a pivotal role in rheumatoid arthritis (RA) and innovative non-pharmacological therapies aimed at limiting cytokine production are highly warranted.
- Conditions
- Cold Exposure, Hyperventilation, Inflammation, Endotoxemia
- Trial name
- EXPOCOL (NCT03240497)
- Testing
- Cold Exposure, Strength Ventilation
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Body Temperature, Hypothermia
Core Body Temperature Measurement During Hot and Cold Environmental Exposure
Accurate measurement of core body temperature at the scene of an accident is critical for both diagnosis and treatment/triage decisions for hypothermic patients.
- Trial name
- NCT01793337
- Testing
- Exposure to cold environmental temperature (-20°C)
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Acute Nasopharyngitis
A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults
2-DG-02 is a randomized, placebo-controlled, double-blind Phase 2 study to investigate the efficacy and safety of 2-Deoxy-D-Glucose as a pre-exposure prophylaxis using the rhinovirus challenge model in healthy study participants.
- Trial name
- NCT06375772
- Testing
- 2-Deoxy-D-glucose
- Where
- Netherlands
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- G.ST Antivirals GmbH
Weight Loss, Cold Exposure
Cold, Appetite and Weight Loss in Individuals With Obesity
This study is an 8 week weight loss intervention with 3 randomly assigned groups: DIET, cold exposure (CE), and DIET+CE. The study will be a total of 13 weeks.
- Conditions
- Weight Loss, Cold Exposure, Appetitive Behavior
- Trial name
- NCT05076357
- Testing
- Caloric Restriction, Cold intervention
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Cold Exposure
Simulation Study on Advanced Medical Procedures Under Extreme Environments
Background: In emergency situations in mountainous regions, medical professionals are often required to perform advanced medical procedures swiftly and efficiently.
- Trial name
- SIMEX-MED (NCT06640595)
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Obesity, Metabolic Disease
Thermogenic Silencer Regulatory Factors in Humans
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST).
- Conditions
- Obesity, Metabolic Disease, Cold Exposure
- Trial name
- NCT06424132
- Testing
- Cold Vest Exposure Period, Rewarming Exposure Period, Fasting
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Cold-water Immersion, High Heat Sauna
Thermodynamic Exposure and Sleep in Military Cadets
This pilot study investigates the effects of cold-water immersion, traditional sauna use, and their combination on sleep architecture and psychological health in military cadets.
- Conditions
- Cold-water Immersion, High Heat Sauna, Combination of Cold-water Immersion and High Heat Sauna
- Trial name
- NCT07201935
- Testing
- Cold Water Immersion, High Heat Sauna
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nitrate, Caffeine
The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.
Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure…
- Conditions
- Nitrate, Caffeine, Cold Exposure
- Trial name
- NCT06602921
- Testing
- TruBeet inorganic beetroot juice, Caffeine, Cold pressor test
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Croup
Impact of Cold Air Exposure on Croup Symptoms
The goal of the present randomised controlled clinical trial is to compare the efficacy of a 30-minute exposition to cold, atmospheric, outdoor air on the severity of croup symptoms with exposition to indoor room air in children…
- Trial name
- NCT05668364
- Testing
- Outdoor cold air exposure
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform