Clinical trials: Collagen Disorders
Nails, Ingrown, Coagulation Defect; Bleeding
Hemostasis Assesment After Application of Lyophilisate Collagen in Nail Surgery
The objective of this study is to evaluate the hemostatic capacity of two types of collagen hemostatic sponges in nail surgery. It is a randomized triple-blind clinical trial with two experimental groups (medium porosity collagen…
- Trial name
- NCT05140161
- Testing
- collagen
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Seville
Scar Keloid
Botulinum Toxin Type a Injection to Prevent Keloid Recurrence
The prospective, split-scar, double-blind, randomized controlled study will enroll the patients who are older than 20 years with progressive keloid lesion which is symmetric.
- Trial name
- NCT05072821
- Testing
- Botulinum Toxin Type A Injection [Botox], 0.9% Sodium Chloride Injection
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Keloids, Fibroblast
Keloid Pathogenesis And Fibroblast Activation Study
Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood.
- Trial name
- KPS (NCT07682636)
- Testing
- Tissue Collection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Aortic Stenosis
Clinical Significance of Collagen Metabolism Changes in Left Cardiac Ventricle
As there are no clinical data in cardiology about the relationship between metabolism collagen changes and their clinical significance, the investigators will check the hypothesis that collagen metabolism changes, detected by…
- Trial name
- NCT00693797
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Erythema, Sensitisation
Irritation Potential of Omeza Collagen Matrix Using Modified HRIPT
The primary objective of this study was to assess the sensitization potential of Omeza Collagen Matrix compared to that of a negative control based on a Modified Human Repeat Insult Patch Test.
- Trial name
- NCT04510675
- Testing
- Test Article, Negative Control
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Back Pain, Low Back Pain
Low Back and Neck Pain in Nursing Students at The University of The West Indies
The purpose of this study is to identify the prevalence of neck and low back pain in nursing students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and…
- Conditions
- Back Pain, Low Back Pain, Musculoskeletal Pain, Neck Pain
- Trial name
- NCT07167888
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- Jamaica
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Vascular Ehlers-Danlos Syndrome, Vascular Ehlers Danlos Syndrome
Metabolic Phenotyping in vEDS
This research study will investigate whether participants with vascular Ehlers-Danlos syndrome (vEDS), a rare inherited condition, have problems with the way the participants' body stores and uses fat (adipose tissue).
- Conditions
- Vascular Ehlers-Danlos Syndrome, Vascular Ehlers Danlos Syndrome, Vascular EDS (vEDS)
- Trial name
- MPEDS (NCT07516496)
- Testing
- No intervention, observational
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Fibrosis, Scarring
High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin
The goal of this study is to establish the safety of high fluence LED-RL from 160 J/cm2 up to 640 J/cm2 in healthy subjects. The hypothesis is that high fluence LED-RL phototherapy is safe in human skin.
- Conditions
- Fibrosis, Scarring, Scar, Wounds
- Trial name
- NCT02630303
- Testing
- LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jared Jagdeo, MD, MS
Bone Resorption
Guided Bone Regeneration Using Fixed vs Non-Fixed Resorbable Collagen Membranes
The aim of this clinical trial is to compare the horizontal bone gain when grafting a bone substitute with non fixed resorbable collagen membranes (control group), versus fixed resorbable collagen membranes (test group) in…
- Trial name
- NCT06334159
- Testing
- Horizontal GBR with the use of non-resorbable pins for the stabilization of the collagen membrane, Horizontal GBR without the use of non-resorbable pins for the stabilization of the collagen membrane
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Gingival Recession
Treatment of Multiple Gingival Recessions With a MCAF or a MCAT and a Collagen Matrix
In a recent meta-analysis, Graziani et al. reported that despite the "ideal" treatment for multiple gingival recession defects is not yet identified, there are some indirect suggestions from the analyzed data that, in comparison…
- Trial name
- NCT04225351
- Testing
- MCAF+CM, MCAT+CM
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Alveolar Bone Loss, Alveolar Bone Resorption
Tomographic and Histologic Assessment on the Influence of the Use of a Collagen Membrane to Protect the Antrostomy After Maxillary Sinus Floor Augmentation.
the aim of the present study was to evaluate the dimensional variation and osseointegration of mini-implants at augmented sinus with the antrostomy left unprotected or protected with a collagen membrane.
- Trial name
- NCT03899688
- Testing
- Maxillary sinus augmentation
- Where
- Colombia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy
Keratoconus
Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT.
Objectives: Measurement of corneal stiffness parameters { Deformation Amlitude (DAR1), Integrated radius, Stress parameter (SP A1), Stress strain index (SSI) and Corvis biomechanical index (CBI) } in keratoconic corneas before…
- Trial name
- NCT05161052
- Testing
- Corvis ST (dynamic Scheimpflug technology)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth-loss
The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)
Tooth loss can in many cases be treated with an artificial titanium root (dental implant) and subsequent manufacture of a porcelain crown.
- Trial name
- NCT04350749
- Testing
- PRF is added in the test group.
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Autoimmune Rheumatologic Disease
Immunogenicity and Safety of MenB Vaccine in Pediatric Patients With Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate the humoral immunogenicity of the meningococcal B vaccine (MenB-4C) in pediatric patients with autoimmune rheumatic diseases (ARDs), compared to age- and sex-matched…
- Trial name
- MENB-PARD (NCT07252804)
- Testing
- Meningococcal B (Bexsero)
- Where
- 2 sites in Brazil
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Osteogenesis Imperfecta
Registry of Osteogenesis Imperfecta
ROI is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- ROI (NCT04115774)
- Testing
- bisphosphonates
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
Keloid, Tattoo
Tattooing and Piercing Among Medical Students
The aim of this study is to evaluate medical students' attitudes towards tattoos and piercings and to measure their awareness of associated dermatological risks.
- Conditions
- Keloid, Tattoo, Infection, Scar
- Trial name
- NCT07673484
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Biruni University
Skin Condition
Efficacy Testing of Collagen Peptide Drink
To assess Collagen Peptide Drink on skin condition improvement
- Trial name
- NCT04996043
- Testing
- Collagen Peptide Drink
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Keratoconus
Accelerated Corneal Collagen Crosslinking Protocols
To evaluate and compare the effect of pulsed light (pl-ACXL) accelerated and continuous light accelerated (cl-ACXL) epithelium-off cross-linking in halting the progression of keratoconus.
- Trial name
- NCT05693740
- Testing
- Accelerated crosslinking (ACXL)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University