Clinical trials: Colon Adenomas
Colon Cancer, Rectal Cancer
Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy
The investigators' null hypothesis is that a withdrawal time of 9 to 10 minutes is non-inferior to a withdrawal time of 12 minutes or greater.
- Conditions
- Colon Cancer, Rectal Cancer, Colorectal Cancer
- Trial name
- NCT05018325
- Testing
- Colonoscopy with 6 minute withdrawal, Colonoscopy 9 minute withdrawal, Colonoscopy 12 minute withdrawal
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Colorectal Cancer, Colorectal Adenoma
To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas
The risk of CRC in families of patients with CRC is well established, but it is less well-defined for families of patients with adenomas.
- Trial name
- NonAA (NCT02521727)
- Where
- 2 sites in Hong Kong
- Volunteers
- 828 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Colorectal Adenoma
Accuracy of Real Time Characterization in Artificial Intelligence-assisted Colonoscopy
The goal of this substudy is to investigate the accuracy of a computer-aided polyp characterization (CADx) system. The main question[s] it aims to answer are: How high is the specificity of the AI system when characterizing…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05754229
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Colonoscopy, Adenomatous Polyp
A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging
The investigators hypothesize that NBI will have a high accuracy in predicting polyp histology real time during a colonoscopy by visualization of the surface mucosal and vascular patterns.
- Conditions
- Colonoscopy, Adenomatous Polyp, Neoplastic
- Trial name
- NBI (NCT00613262)
- Testing
- Narrow Band Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Colorectal Polyp, Colorectal Adenoma
Standard Colonoscopy Versus Colonoscopy With Endocuff Vision
This study seeks to compare colonoscopy results between a standard method and one using a distal scope attachment (Endocuff Vision).
- Conditions
- Colorectal Polyp, Colorectal Adenoma, Colon Cancer
- Trial name
- NCT03361917
- Testing
- Endocuff Vision
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colon Cancer
Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon
Linked color imaging (LCI) and magnifying blue laser imaging (BLI) are two new imaging systems used in endoscopy which are recently developed. BLI was developed to compensate for the limitations of NBI.
- Trial name
- NCT02724397
- Testing
- LCI/BLI then white endoscopy, White endoscopy and then LCI/BLI
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Colonic Polyps, Colonic Neoplasms
Development of Quality Indicators and Quality Improvement Plan of Colonoscopy in Experienced Endoscopist
The purpose of this study is to determine clinical factors affecting quality indicators of colonoscopy including adenoma detection rate, and whether quality of colonoscopy could be elevated by improving related factors.
- Trial name
- NCT02385552
- Testing
- Feedback
- Where
- 2 sites in South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colon Adenoma
Risk Factors of Poor Bowel Cleansing in Inpatients
The main purpose of the study is to determine risk factors of poor bowel cleansing in inpatients after a split-dose high volume preparation with 4 liters of polyethylene glycol.
- Trial name
- NCT03902561
- Testing
- one time colonoscopy in inpatients
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Canarias
Colonic Cancer
A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy
To determine the prevalence of colonic neoplasm in patients who had previously undergone screening colonoscopy To determine the optimal time interval for re-screening in average risk individuals To determine potential baseline…
- Trial name
- NCT00280332
- Testing
- colonoscopy
- Where
- China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Adenoma Colon, Polyp of Colon
Computer-aided Detection of Colorectal Polyps
In this observational pilot study, we assess the diagnostic performance of an artificial intelligence sytem for automated detection of colorectal polyps.
- Trial name
- NCT04359355
- Testing
- Artificial Intelligence System for Detection of colorectal polyps
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Colorectal Cancer, Colorectal Adenoma
Protein Signature Based Screening of Colorectal Adenomas and Cancer
Colorectal cancer is a common cancer, that in general develops over a long time period (approximately 10-15 years) from precancerous polyps. The disease is in many cases asymptomatic.
- Trial name
- NCT07881549
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Colonic Adenomas
Diagnosis of Colonic Adenomas by Bright Narrow Band Imaging (B-NBI)
Early detection of colo-rectal adenoma using colonoscopy can prevent occurrence of colon cancers. While colonoscopy is a standard technique, it can miss early cancers.
- Trial name
- NCT01422577
- Testing
- Bright Narrow Band Imaging, White light Endoscopy
- Where
- China
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
MutYH-associated Polyposis
MUTYH-associated Polyposis
This is single-center, prospective, non-randomized study
- Trial name
- MAP (NCT03847532)
- Testing
- Sanger sequencing method
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Colorectal Neoplasms, Colorectal Polyp
MS Versus NICE for Colorectal Lesions
OBJECTIVE: Our study aimed to compare a recently-developed endoscopic classification with an established one for colorectal lesions in a randomised trial between 2013 and 2015.
- Trial name
- NCT02963207
- Testing
- Modified Sano's classification, NICE classification
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital
Colorectal Cancer, Colorectal Polyp
Epigenetic Regulation of Colorectal Polyps and Cancer
The goal of this study is to learn about the epigenetic and genetic regulation (microRNA/mRNA) of colorectal polyps and their evolvement as polyps and to colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT06206603
- Testing
- Intestinal biopsies, Blood sample
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Region Skane
Colorectal Cancer, Colorectal Neoplasms
Molecular Effects of Aspirin & Metformin on Colonic Epithelium
Bowel cancer, a significant problem in the United Kingdom (UK) with ~ 41,000 diagnoses and ~ 16,000 deaths annually, has a large preventable component (~54%).
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT05158374
- Testing
- Aspirin tablet, Metformin, Aspirin and Metformin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Edinburgh
Sessile Colonic Polyp, Serrated Lesion
Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions
The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided…
- Conditions
- Sessile Colonic Polyp, Serrated Lesion, Sessile Serrated Lesion, Colon Adenomas
- Trial name
- NCT07127471
- Testing
- Water exchange with AI-assisted detection, Water exchange with AI-assisted detection and LCI
- Where
- 4 sites in Canada, Italy and 2 more
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Colorectal Cancer, Colorectal Adenoma
Circulating Tumor DNA in Patients Summoned for Colonoscopy; - a Liquid Biopsy for Detection, Characterization, Individualized Treatment and Follow-up of Colorectal Cancer
CoLiQ is a clinical study designed to evaluate the clinical usefulness of circulating tumor DNA (ctDNA) markers found in blood, as a liquid biopsy for diagnosis, prognosis and follow-up of colorectal cancer.
- Trial name
- CoLiQ (NCT06307938)
- Testing
- liquid biopsy
- Where
- Norway
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Helse Nord-Trøndelag HF
Colon Cancer, Colon Diseases
PeerScope B System™ Clinical Protocol
The PeerScope B System™ by PeerMedical Ltd. is intended to provide visualization (via a video monitor) and therapeutic access to the lower intestinal tract.
- Conditions
- Colon Cancer, Colon Diseases, Colon Polyps, Colon Adenomas
- Trial name
- NCT01483040
- Testing
- colonoscopy system (PeerScope B System™)
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PeerMedical Ltd.