Clinical trials: Colon Rectal Cancer
Colorectal Cancer
Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program
The investigators propose a randomized controlled trial to develop and evaluate the impact of promoting advice on diet and lifestyle recommendations for cancer prevention at colorectal cancer screening among individuals who may…
- Trial name
- LIFE-SCREEN (NCT04257526)
- Testing
- Diet and lifestyle advice following a positive FIT test and diagnostic colonoscopy.
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Colorectal Cancer
The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
The investigators will expand an existing, patient-centered, health literacy strategy to promote longer-term adherence to colorectal cancer (CRC) screening in resource-limited, rural health clinics via colonoscopy or annual fecal…
- Trial name
- NCT04313114
- Testing
- health literacy appropriate education and demonstration, shared decision making, automated call reminders or automated texts
- Where
- 3 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Colorectal Cancer
Identification of New Colorectal Cancer Genes
The purpose of this study is to define new genes for family risks of developing colon cancer.
- Trial name
- NCT00582335
- Where
- United States
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
ColoRectal Cancer and Inflammatory Bowel Disease
Impact of the Enhanced Recovery After Surgery System for Colorectal Surgery
This is an observational study to look at the impact of the Enhanced Recovery After Surgery system for colorectal surgery (Group 1) in shortening hospital length of stay, reducing postoperative narcotic consumption, lowering…
- Trial name
- NCT02997293
- Testing
- Enhanced Recovery protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Colorectal Cancer
Using Multimedia Approaches to Communicate Probabilities in Patient Decision Aids for Low-Literacy Populations: Randomized Trial
The goal of this research study is to compare how people who are 45-75 years old respond to 3 different versions of a program about screening tests for colorectal cancer.
- Trial name
- NCT02151032
- Testing
- Booklet, Audio CD, Video with Non-Moving Images
- Where
- 4 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy, Colorectal Cancer
Zinc Supplementation on Markers of Oxidative Stress in Post Operative Colorectal Cancer During Chemotherapy Cycles
Objective: To determine the oxidative stress during cycles of chemotherapy in patients after surgery for colorectal cancer, with or without oral zinc supplementation.
- Trial name
- NCT02106806
- Testing
- Zinc
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Non-resectable Metastatic Cancer of the Lung, Non-resectable Metastatic Cancer of the Colon
Viewpoints on the Social Representations and Rationale Concerning the Choices of Patients, Doctors and Caregivers With Regard to the Management of Patients With Non-resectable Metastatic Cancer of the Colon, Stomach, Bile Ducts, Rectum, Pancreas or Lung, or Gastrointestinal Neuroendocrine Tumours
Reflexion on the therapeutic strategies to implement in patients at the end of life is advancing rapidly in France. However, beyond the choices presented to patients, sometimes even the decision to carry on, to limit or to stop…
- Conditions
- Non-resectable Metastatic Cancer of the Lung, Non-resectable Metastatic Cancer of the Colon, Non-resectable Metastatic Cancer of the Rectosigmoid Junction, Non-resectable Metastatic Cancer of the Stomach
- Trial name
- EOLE (NCT03328065)
- Testing
- Interviews, Questionnaires
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Peritoneal Carcinomatosis, Peritoneal Metastases
CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)
This is an open-label, dose-escalation, phase I trial of the safety and efficacy of anti-CEA intraperitoneal CAR-T infusions for treatment in patients with CEA-expressing adenocarcinoma peritoneal metastases or malignant ascites.
- Conditions
- Peritoneal Carcinomatosis, Peritoneal Metastases, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT03682744
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sorrento Therapeutics, Inc.
Colorectal Neoplasms, Urologic Neoplasms
Transvaginal Versus Transabdominal Extraction of Laparoscopically-excised Specimen
The aim of this study is to evaluate the outcomes of transvaginal natural orifice specimen extraction (NOSE) in patients who are planning multiport laparoscopic surgery for resection of solid organs including kidney, liver…
- Conditions
- Colorectal Neoplasms, Urologic Neoplasms, Gastrointestinal Neoplasms, Neoplasms by Site
- Trial name
- STTELS (NCT05113134)
- Testing
- Transvaginal natural orifice specimen extraction (NOSE)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Esophageal Cancer, Gastric (Stomach) Cancer
Establishment of Molecular Classification Models for Early Diagnosis of Digestive System Cancers
This is a single blind, case control, multicenter study jointly developed by Zhongshan Hospital of Fudan University, Shanghai Public Health Clinical Center, Shanghai Xuhui Central Hospital, Qingpu Branch of Zhongshan Hospital…
- Conditions
- Esophageal Cancer, Gastric (Stomach) Cancer, Colorectal Cancer, Hepatocellular Carcinoma
- Trial name
- NCT05431621
- Where
- 4 sites in China
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer
Preliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention
The aim of this study is to assess the feasibility of beta-hydroxybutyrate (BHB) supplementation in individuals who are undergoing a standard-of-care colonoscopy or flexible sigmoidoscopy.
- Trial name
- BHB-CRC (NCT05338307)
- Testing
- R-1,3-Butanediol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer, Colorectal Adenomatous Polyp
Stool-based SDC2 DNA Methylation Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer
The primary objective is to compare the performance of Stool-based SDC2 DNA Methylation Test and commercially available Fecal Immunochemical Test(FIT) , on the detection rate of advanced adenomatous polyps and colorectal cancer…
- Conditions
- Colorectal Cancer, Colorectal Adenomatous Polyp, Screening
- Trial name
- NCT04221854
- Testing
- Stool-based SDC2 DNA methylation test, Fecal immunochemical test
- Where
- 8 sites in China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Nutrition Related Neoplasm/Cancer
Dietary Factors Associated to Colorectal Premalignant Lesions (COLOMAR-1)
This study aims to find a correlation between fish protein intake and other dietary habits and colorectal premalignant lesions in healthy volunteers.
- Trial name
- NCT06368661
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundación Vithas
Colorectal Neoplasms, Colonic Polyp
BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities
This study aims to assess the effect, if any, on the adenoma detection rate of BowelScope bowel cancer screening flexible sigmoidoscopies by using the Endocuff Vision device.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Neoplasia GI
- Trial name
- B-ADENOMA (NCT03072472)
- Testing
- Endocuff Vision
- Where
- 16 sites in United Kingdom
- Volunteers
- 3,221 people, healthy volunteers welcome
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Colorectal Cancer
Anthocyanin-Rich Berry Supplementation in Patients With Colorectal Cancer
This prospective, open-label interventional study evaluated the effects of short-term supplementation with an anthocyanin-rich freeze-dried black raspberry and strawberry preparation in patients undergoing treatment for…
- Trial name
- NCT07819539
- Testing
- Anthocyanin-Rich Freeze-Dried Berry Supplement
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Colorectal Cancer
Decision Aid to Technologically Enhance Shared Decision Making
Physicians face a challenge in promoting colorectal cancer screening (CRCS) in the face of multiple competing demands. A decision aid (DA) that clarifies patient preferences and improves decision quality could aid shared decision…
- Trial name
- DATES (NCT01514786)
- Testing
- Colorectal Web
- Where
- 14 sites in United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colonoscopy
Implementation of Evidence Based Practices for Colonoscopy: The Strategies to Improve Colonoscopy Study
The purpose of this study is to compare the effect of physician education about evidence based practices for colonoscopy alone, versus physician education plus a multi-component staff implementation strategy to improve adequacy…
- Trial name
- STIC (NCT02723370)
- Testing
- Staff multi-component implementation strategy
- Volunteers
- 46,184 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Colorectal Cancer, Exercise, Aerobic
Pedaling at a Low-Moderate Intensity During Chemotherapy Administration
The purpose of this study is to evaluate the feasibility of completing a low-moderate intensity pedaling session concurrent to chemotherapy treatment for colorectal cancer.
- Conditions
- Colorectal Cancer, Exercise, Aerobic, Chemotherapy, Chemotherapeutic Toxicity
- Trial name
- NCT04258969
- Testing
- Pedaling
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Colorectal Cancer
Radiation Therapy on Pelvic Floor Disorders in Women
Investigators propose a retrospective cohort study to examine the impact of radiation therapy on the global pelvic floor function of women who have completed the immediate surveillance period for colorectal cancer
- Trial name
- RadPFD (NCT04623515)
- Testing
- REDCap Questionnaires
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences