Clinical trials: Colonic Dysplasia
Inflammatory Bowel Disease
Confocal Endomicroscopy During Endoscopy
The main objective of this study is to determine the role of epithelial cell homeostasis in the pathogenesis of intestinal diseases.
- Trial name
- NCT00988273
- Testing
- Confocal endomicroscopy
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Ulcerative Colitis
High Definition Versus Chromoendoscopy for Dysplasia Detection in Ulcerative Colitis (UC)
Patients with ulcerative colitis (UC) have an increased risk for colorectal cancer (CRC) compared to the general population. Regular screening by colonoscopy is an internationally recommended cancer prevention strategy.
- Trial name
- NCT02138318
- Testing
- High definition (HD) endoscopy, chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Optical Biopsy, Colonic Dysplasia
Diagnostic Accuracy of Real-time Optical Biopsy
Differentiating neoplastic tissue from healthy tissue is fundamental for both early diagnosis during endoscopic examinations and radicality of the oncological interventions.
- Conditions
- Optical Biopsy, Colonic Dysplasia, Diagnostic Accuracy
- Trial name
- INSTASCOPE (NCT05858970)
- Volunteers
- 27 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC)
Narrow Band Imaging Versus Artificial Intelligence for Colonic Surveillance in Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) - ulcerative colitis or Crohn's disease - have a higher risk of developing colorectal cancer than the general population.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC), Crohn's Disease Colon, Colonic Dysplasia/Adenomata
- Trial name
- CLEAR-IBD (NCT07694362)
- Testing
- ENDO-AID CADe System (Olympus, Tokyo, Japan) (AI device)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vall d'Hebron Institute Research
Ulcerative Colitis, Dysplasia
Development of Dysplasia in the Pelvic Pouch in Patients With Ulcerative Colitis (UC) and Risk Factors
The purpose of this study is to study development of dysplasia in the ileal mucosa among patients with Ulcerative Colitis and who previous have hade risk factors for developing cellular changes/dysplasia, i.e.
- Conditions
- Ulcerative Colitis, Dysplasia, Surgery
- Trial name
- NCT01764542
- Testing
- Endoscopy and biopsy
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Mattias Block
Colonic Neoplasms, Colonic Polyps
Strigolactones and Dysplastic Colonic Lesions or Cancer
The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
- Trial name
- NCT02824835
- Testing
- biopsy during colonoscopy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Ulcerative Colitis
Indigo Carmine Staining and Narrow Band Imaging (NBI) of Colonic Mucosa for Detection of Dysplasia in Ulcerative Colitis
A prospective, randomized trial to determine indigo carmine dye spraying and narrow band imaging (NBI) of colonic mucosa to detect dysplasia in ulcerative colitis (UC).
- Trial name
- NCT00961948
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Colon Carcinoma, Barrett Esophagus
Safety and Feasibility of Immuno-OCT
To improve detection of premalignant lesions in the gastrointestinal tract (the rectum and the esophagus) there is a need for better endoscopic visualization and the ability for targeted biopsies.
- Conditions
- Colon Carcinoma, Barrett Esophagus, Gastrointestinal Dysplasia
- Trial name
- DETOUR (NCT06008522)
- Testing
- Bevacizumab-800CW
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Inflammatory Bowel Disease, Colorectal Cancer
Risk Factors for Colorectal Cancer in Patients With Inflammatory Bowel Disease Undergoing Surveillance: a Prospective Cohort Study
Both ulcerative colitis and Crohn's colitis are associated with an increased risk of developing colorectal cancer (CRC). Although the increased risk of CRC in colitis patients is well established, several studies show that the…
- Trial name
- NCT01464151
- Where
- 4 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- UMC Utrecht
Colonic Polyp
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps).
- Trial name
- NCT01062035
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colonic Dysplasia, Adenomatous Polyps
Study of Performance of Confocal Endomicroscope With Fluorescein Imaging Agent in the Colon
The overall aim of this research project is to evaluate the imaging performance of a confocal endomicroscope. Fluorescein, an FDA-approved topical fluorescent dye, will be used to provide topical mucosal contrast.
- Conditions
- Colonic Dysplasia, Adenomatous Polyps, Irritable Bowel Disease
- Trial name
- NCT03220711
- Testing
- confocal endomicroscope, Fluorescein
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Ulcerative Colitis, Dysplasia
Surveillance in Ulcerative Colitis: Narrow Band Image Versus Chromoendoscopy for High-risk Groups
The risk of colorectal cancer (CRC) is increased in patients having ulcerative colitis (UC). Patients with long-standing extensive colitis, concomitant primary sclerosing cholangitis, or previous history of dysplasia carry an…
- Trial name
- SUNRISE-High (NCT04257084)
- Testing
- chromoendoscopy with target biopsy; NBI with target biopsy
- Volunteers
- 188 people
- Sponsor
- Asan Medical Center
Colonic Polyp, Colonic Neoplasms
Real-World Validation of an Artificial Intelligence Characterization Support (CADx) System
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, with rates of CRC predicted to increase. Colonoscopy is currently the gold standard of screening for CRC.
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT05034185
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- Singapore
- Volunteers
- 450 people
- Sponsor
- Changi General Hospital
Colorectal Cancer, Image
SGM-101 Tumor Targeted Fluorescence Endoscopy in Rectal Polyps With Suspected T1 Adenocarcinoma or High Grade Dysplasia
This will be the first trial investigating whether tumor targeted fluorescence is able to discriminate invasive T1 carcinoma / High grade dysplasia from Low grade dysplasia/normal tissue during endoscopic intraluminal resection.
- Conditions
- Colorectal Cancer, Image, Low Grade Dysplasia of Colon
- Trial name
- SGM-T1 (NCT06280690)
- Testing
- SGM-101
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
Inflammatory Bowel Disease
Virtual Chromoendoscopy for Colitis Surveillance: A Feasibility Study
Patients with colitis require regular 'surveillance' colonoscopy as their risk of developing colon cancer is at least 2.5 times that of the general population.
- Trial name
- NCT02543021
- Testing
- Virtual chromoendoscopy, Conventional chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Pancreatic Cancer, Pancreas Cancer
Pancreatic Cancer Early Detection Program
Early detection testing is recommended for individuals at elevated risk for the development of Pancreatic Cancer. This Protocol will define sufficiently elevated risk as either equal to or greater than five times the general…
- Conditions
- Pancreatic Cancer, Pancreas Cancer, Pancreatic Adenocarcinoma, Familial Pancreatic Cancer
- Trial name
- PCEDP (NCT02206360)
- Testing
- Endoscopic Ultrasound, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- White Plains Hospital
Colitis, Colonic Dysplasia
Improved and Simplified Staining Technique for Dysplasia Detection in Colitis
Comparing chromoendoscopy to a digital staining technique and White light in patients with IBD attending scheduled surveillance colonoscopy
- Conditions
- Colitis, Colonic Dysplasia, Inflammatory Bowel Diseases, Colonoscopy
- Trial name
- IST-DDC (NCT06223347)
- Testing
- Chromoendoscopy
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Vastra Gotaland Region
Ulcerative Colitis
Linked Color Imaging vs. White Light for Colorectal Dysplasia in Ulcerative Colitis
The purpose of the study is to determine whether a new colonoscopic viewing technique called Linked color imaging(LCI) helps endoscopists detect more dysplasia lesions in ulcerative colitis patients than conventional colonoscopy…
- Trial name
- NCT02772406
- Testing
- Linked Color Imaging, white light imaging
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Inflammatory Bowel Diseases, Dysplasia Colon
OPtical Diagnosis Training to Improve Dysplasia Characterisation in IBD
People with inflammatory bowel diseases (IBD) can be at higher risk of developing abnormal areas in their bowel. These abnormal areas can be due to active inflammation, healed inflammation, polyps or pre-cancerous changes…
- Conditions
- Inflammatory Bowel Diseases, Dysplasia Colon, Dysplasia, Crohn Disease-Associated, Polyp of Colon
- Trial name
- OPTIC-IBD (NCT04924543)
- Testing
- Online self-learning training module, Refresher training
- Where
- 5 sites in Canada, Italy and 1 more
- Volunteers
- 182 people
- Sponsor
- University of Birmingham
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute