Clinical trials: Colonic Lesions
Flat Colorectal Lesion
Comparison of Flat Colorectal Lesion Detection by Artificial Intelligence-assisted Colonoscopy Versus Endoscopists
The development of artificial intelligence (AI) systems in the field of colorectal endoscopy is currently booming, colorectal cancer being, by its frequency and severity, a real public health problem.
- Trial name
- AIChallengeMed (NCT05942677)
- Testing
- proportion of colorectal lesions
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Cancer, Metastatic Liver Cancer
Anti-CEA CAR-T Cells to Treat Colorectal Liver Metastases
Recurrence of liver metastasis in colorectal cancer after R0 resection is mainly due to the invisible minimal residual disease, which are the main factors leading to metastasis and recurrence.
- Trial name
- NCT05240950
- Testing
- Anti-CEA CAR-T Cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital
Colorectal Neoplasms, Colonic Polyp
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial
This study is a multi-center, randomized controlled trial designed to evaluate whether an artificial intelligence (AI) system can assist endoscopists to improve the detection rate of colorectal adenomas and cancers during…
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Colorectal Cancer
- Trial name
- AI-COLOADR (NCT07307547)
- Testing
- AI-Assisted Colonoscopy
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Adenoma, Colorectal Neoplasms
Conventional Endoscopic Mucosal Resection vs Underwater Resection for Colorectal Non-pedunculated Colorectal Lesions
Randomized, comparative and prospective study between Conventional Endoscopic Mucosal Resection for the removal of flat or sessile colorectal lesions without previous attempt to resection.
- Trial name
- NCT03021135
- Testing
- Conventional Endoscopic Mucosal Resection, Underwater Endoscopic Mucosal Resection
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon
Systematic Description of the Post EMR Defect
To date there are no available data on the utility of the endoscopic mucosal resection (EMR) defect in stratifying the risk of immediate or delayed adverse outcomes, particularly clinically significant post EMR bleeding (CSPEB).
- Conditions
- Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon, Endoscopic Mucosal Resection
- Trial name
- NCT03117400
- Where
- Australia
- Volunteers
- 482 people
- Sponsor
- Western Sydney Local Health District
Colonic Polyp, Colonic Sessile Serrated Lesion
The CARMA Technique Study
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers…
- Trial name
- NCT05099432
- Testing
- CARMA technique
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Colorectal Cancer, Liver Metastasis
Feasibility Study of Neoadjuvant Chemotherapy Modified FOLFOX6 for Resectable Liver Metastases of Colorectal Cancers
The purpose of this study is to evaluate the safety of liver resection for metastatic, resectable lesions from colorectal cancers after systemic chemotherapy.
- Trial name
- NCT00594529
- Testing
- Surgery
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Kyoto University
Vascular Lesion
Oxygenation in Vascular Lesions of the Colon
The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.
- Trial name
- NCT06230731
- Testing
- Oxygen saturation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Colorectal Cancer
Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 3
This study is a clinical validation of PolyDeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. PolyDeep Advance 3 is a multicentric randomized clinical trial comparing high definition colonoscopy…
- Trial name
- NCT05513261
- Testing
- High definition colonoscopy (standard colonoscopy) in Adenoma Detection Rate, PolyDeep assisted high definition colonoscopy (CAD system) in Adenoma Detection Rate
- Where
- 3 sites in Spain
- Volunteers
- 857 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Adenoma Colon, Colon Adenoma
Conventional Endoscopic Mucosal Resection Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial
Comparing the complete resection rate and subsequent adenoma recurrence rate at surveillance colonoscopy of 15-40mm laterally spreading adenomas for conventional EMR vs. cold snare EMR.
- Conditions
- Adenoma Colon, Colon Adenoma, Colon Cancer
- Trial name
- NCT04138030
- Testing
- Conventional Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- Western Sydney Local Health District
Crohn Disease (CD), Colitis Ulcerative
Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study
Inflammatory Bowel Disease (IBD) patients have an increased risk of ColoRectal Cancer (CRC). The cumulative risk of CRC development is estimated at 1% after 10 years of disease progression, 2% after 20 years, and 5% after more…
- Trial name
- IB DYSPLASIA (NCT07719426)
- Volunteers
- 800 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Colorectal Neoplasm, Sessile Serrated Lesion
Detection and Characterization of Sessile Serrated Lesions (SSL) of the Right Colon
There are a few studies regarding Sessile Serrated Lesions (SSL). They are recently identified as precancerous lesions. Yet, digestive tract serrated lesions would be part of a new colic carcinogenesis way : the serrated tumor…
- Conditions
- Colorectal Neoplasm, Sessile Serrated Lesion, Neoplasms
- Trial name
- Lesion SSL (NCT02861885)
- Testing
- Chromoendoscopy
- Where
- 6 sites in France
- Volunteers
- 71 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Carcinoma
An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin
The goal of this clinical research study is to learn more about the possible effects of metformin extended release (ER) in patients with colon cancer or adenomas who are about to have surgery.
- Trial name
- NCT01816659
- Testing
- Metformin ER
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Sessile Serrated Lesion, CADe
USAGE OF ARITIFICIAL INTELLIGENCE IN AIDING WITH COLONIC SESSILE SERRATED LESIONS DETECTION AND DIAGNOSIS (AI-SSL)
The aim of this study is to is to evaluate if a real-time Computer Aided Detection (CADe) system can help improve the detection of SSL(sessile serrated lesions) versus a conventional colonoscopy (CC) using white light…
- Trial name
- AI-SSLD (NCT07650344)
- Testing
- usage of CADe system
- Where
- 3 sites in Singapore
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- National Healthcare Group, Singapore
Colorectal Neoplasms, Colorectal Polyp
MS Versus NICE for Colorectal Lesions
OBJECTIVE: Our study aimed to compare a recently-developed endoscopic classification with an established one for colorectal lesions in a randomised trial between 2013 and 2015.
- Trial name
- NCT02963207
- Testing
- Modified Sano's classification, NICE classification
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital
Colorectal Neoplasms
Underwater Resection of Non-pedunculated Colorectal Lesions
The aim of this study is to compare the efficacy of underwater resection (polypectomy) versus conventional polypectomy techniques for small and large colorectal lesions identified during colonoscopy.
- Trial name
- NCT02889679
- Testing
- Underwater resection, Conventional (gas distended colon) resection, Standard polypectomy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- VA Northern California Health Care System
Procedural Bleeding, Delayed Bleeding
A Comparison of Eleview Versus Hetastarch as Injectate for EMR
EMR is a technique used for the removal of flat or sessile neoplasms confined to the superficial layers of the GI tract using a snare.
- Conditions
- Procedural Bleeding, Delayed Bleeding, Post-Polypectomy Syndrome, Post Procedural Complication
- Trial name
- NCT03350217
- Testing
- Eleview, Hetastarch
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colon Adenoma, Colon Polyp
Artificial Intelligence-assisted Colonoscopy on Detection of Missed Proximal Lesions
This is a prospective multi-center randomized study is to determine whether the use of artificial intelligence (AI)-assistance could reduce the miss rates of polyps and adenomas in the proximal colon during tandem examination
- Trial name
- NCT04294355
- Testing
- Artificial intelligence-Assisted colonoscopy, Conventional colonoscopy
- Where
- 3 sites in China, Singapore and 1 more
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Colonic Disease
Efficacy, Safety and Recurrence After Cold-EMR Plus APC for Large Colonic Lesions
This prospective observational study aims to evaluate the efficacy, safety and recurrence of cold-snaring for large colonic lesions combined with argon plasma coagulation of the resection bed.
- Trial name
- EMR+APC (NCT06435377)
- Testing
- Procedure: Cold EMR + APC
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Clinico Humanitas
ColoRectal Cancer, Colonic Polyp
Retrospective Study on Epidemiology of Colorectal Lesions
Retrospective analysis on colonoscopies in the endoscopy unit of the Lyell McEwin Hospital.
- Conditions
- ColoRectal Cancer, Colonic Polyp, Colonic Neoplasms
- Trial name
- NCT03035136
- Volunteers
- 2,658 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital