Clinical trials: Colonisation
Whooping Cough
Bordetella Pertussis Colonisation Challenge Study
This is a prospective controlled human challenge study consisting of two phases; Phase A: Development of a B. pertussis human challenge model; pilot to establish the standard inoculum Phase B: Development of a modified B.
- Trial name
- Periscope (NCT03751514)
- Testing
- Bordetella Pertussis B1917, Azithromycin 500 mg, Sterile Saline
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Infection of Catheter Exit Site, Catheter Related Infection
Alcoholic Chlorhexidine Compared to Povidone Iodine to Limit Perineural Catheter Colonisation
Implementation of perineural catheters may lead to infection by catheter colonization. Catheters may be colonized by the bacteria present on the skin.
- Trial name
- CHLOVEPI (NCT02950246)
- Testing
- perineural catheterization implementation, 2% alcoholic chlorhexidine, povidon iodine
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hôpital Raymond Poincaré
Upper Respiratory Tract Infections
Birth Cohort Study for Respiratory Infections
The primary objectives are to evaluate relationship between nasopharyngeal microbial colonization and the occurrence of AOM or pneumonia in infants.
- Trial name
- NCT02361164
- Where
- Bangladesh
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Microbial Colonization
Microbial Colonization of Oral Probiotics
The aim of this study is to evaluate the colonization efficacy of probiotic lozenges and powders containing specific prebiotics in healthy adults
- Trial name
- NCT05375383
- Testing
- Streptococcus salivarius K12 lozenge, Probiotic S. salivarius K12 lozenges containing prebiotic A, Probiotic S. salivarius K12 lozenges containing prebiotic B
- Where
- New Zealand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Microbial Colonization
Probiotic Toothpaste for Microbial Colonization
The aim of this study is to evaluate the colonization efficacy of probiotic toothpastes in healthy adults
- Trial name
- NCT05480020
- Testing
- Streptococcus salivarius M18 toothpaste
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- John Hale
Streptococcal Pneumonia
A Study of Streptococcus Pneumonia Colonisation and Invasive Disease in Cambodian Children
Streptococcus pneumoniae (the pneumococcus) remains a leading cause of childhood mortality and morbidity. Between 2007 and 2012, Angkor Hospital for Children (AHC), Siem Reap, Cambodia documented that S.
- Trial name
- PCV (NCT03331952)
- Testing
- Prospective study, Cross-sectional surveys
- Where
- Cambodia
- Volunteers
- 4,111 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pertussis Infection, Pertussis Vaccines
A Phase 4, Randomised Vaccination Study in Healthy Adults to Investigate the Effects of Acellular Pertussis Vaccine on Colonisation With Bordetella Pertussis Using Controlled Human Infection
The goal of this clinical trial is to investigate the effect of booster vaccination with acellular pertussis vaccine on colonization with Bordetella pertussis using a controlled human infection model in healthy volunteers.
- Trial name
- KIM (NCT06903221)
- Testing
- Tdap-IPV, Td-IPV
- Where
- Netherlands
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dimitri Diavatopoulos
Healthy Infants
Colonisation Resistance Study
This study is initiated to investigate the effect of infant formulas with added specific prebiotic oligosaccharides on the reduction of specific potential pathogens and/or toxins.
- Trial name
- ColoR (NCT01507935)
- Testing
- Regular non-hydrolysed cow's milk
- Where
- 2 sites in Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Microbial Colonization
Colonisation of Scalp by Topical Probiotic Micrococcus Luteus Q24
The purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic Micrococcus luteus Q24 (BLIS Q24) to the scalp from a serum format in healthy adults.
- Trial name
- NCT06166979
- Testing
- Active Comparator: Study Group A: Blis Q24 Serum at higher dose, Active Comparator: Study Group B: Blis Q24 Serum at lower dose
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Bacteria Infection Mechanism
Study of Factors Influencing the Dynamics of Colonisation and Decolonisation of the Digestive Tract by Clostridioides Difficile in Infants
Clostridioides difficile (formerly C. difficile) is a bacterium found in the form of spores (a resistant form) to which patients may be exposed in a hospital environment.
- Trial name
- BBDIFF (NCT07512908)
- Testing
- cohort follow up
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Candidiasis, Vulvovaginal
Study Evaluating the Optimal Dosage for Equivalence Between Lcr Regenerans® Capsules and Tablets (Lactobacillus Rhamnosus Lcr35®) on the Vaginal Flora Colonisation
The primary objective of this study is to study the vaginal flora colonisation equivalence between the tablet and capsule dosage forms of a treatment with Lcr Regenerans® between D0 (V1) and Dend of treatment.
- Trial name
- COMPRIGEL (NCT02730494)
- Testing
- Lcr Regenerans® vaginal capsules, Lcr Regenerans® vaginal tablet
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biose
COPD
Mechanisms and Impact of Bacterial Colonisation in COPD
COPD is a leading cause of lung disease and a common cause of hospitalisation, time off work and death. Smoking is the major factor associated with development of COPD.
- Trial name
- NCT03161561
- Testing
- capacity of primary phagocytes
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Microbial Colonization
Probiotic Toothpaste to Assess Microbial Colonization
The aim of this study is to evaluate the colonization efficacy of probiotic toothpastes in healthy adults
- Trial name
- NCT06015958
- Testing
- Streptococcus salivarius M18 toothpaste (1 million cfu), Streptococcus salivarius M18 toothpaste (10 million cfu)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Sore Throat, Tonsillitis
The BLIS Study: a Feasibility Study Assessing Compliance, Acceptability and Colonisation With Different Dosing Regimens of the Probiotic Supplement Streptococcus Salivarius K12 (Bactoblis®) in Adults
Short title The BLIS study Full title A feasibility study assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis®) in adults…
- Conditions
- Sore Throat, Tonsillitis, Pharyngitis
- Trial name
- NCT04297878
- Testing
- probiotic supplement Streptococcus salivarius K12 (Bactoblis®)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southampton