Clinical trials: Colonization
Streptococcus Pneumoniae Pneumonia, Streptococcus Pneumoniae Infection
Pneumococcal Nasopharyngeal Colonization as Predictor of Community-Acquired Pneumonia (CAP) in Adults With Chronic Diseases.
Streptococcus pneumoniae (pneumococcus) is a commensal bacterium, often isolated in the nasopharynx of preschool children and older adults with weakened immune systems, a pathogen that remains the leading cause of…
- Conditions
- Streptococcus Pneumoniae Pneumonia, Streptococcus Pneumoniae Infection, Streptococcus Pneumoniae Infection Invasive, Community-acquired Pneumonia
- Trial name
- CAP (NCT04944719)
- Testing
- nasopharyngeal aspirate
- Where
- Colombia
- Volunteers
- 810 people
- Sponsor
- Universidad de la Sabana
Tracheal and Oropharyngeal Colonization by Gram-negative Pathogens
Oral Care and Gram-negative Pathogen in Children
Critical care nursing interventions related to oral care can reduce the microorganisms in the oropharynx available for translocation to other sites.
- Trial name
- NCT01410682
- Testing
- 0,12% digluconate chlorhexidine, toothbrushing
- Volunteers
- 74 people
- Sponsor
- Federal University of São Paulo
Prematurity, Microbial Colonization
Microbiome Establishment in Preterm Infants
Our bodies are home to millions and millions of microbes (bacteria, fungi and viruses), that live in harmony with us without producing any negative (disease producing) effects.
- Trial name
- PIMENTO (NCT05803577)
- Where
- Ireland
- Volunteers
- 91 people
- Sponsor
- University College Cork
Nasal Carriers of Staphylococcus Aureus
Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment
Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the nostrils twice daily for 5 days is the current…
- Trial name
- NCT00997139
- Testing
- Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postoperative Wound Healing
Chlorhexidine Gel After Third Molar Surgery
This study evaluates whether placing 0.2% chlorhexidine gel into the tooth socket after lower wisdom tooth surgery improves gum healing, reduces bacteria on surgical stitches, and decreases postoperative pain, swelling, and…
- Trial name
- NCT07895251
- Testing
- Chlorhexidine 0.2% Gel
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Health Services Administration, Genetic Predisposition
Genome Driven Primary Care Clinics - an RCT
A cluster randomized controlled study of 40 primary care clinics in Northern Israel (20 intervention clinics, 20 usual care clinics) to evaluate the value of introducing a precision medicine/genomic approach/paradigm on the…
- Conditions
- Health Services Administration, Genetic Predisposition, Microbial Colonization
- Trial name
- NCT04781205
- Testing
- Mutation arrays, NGS panels, GWAS, WES, WGS,, wearable monitors
- Where
- Israel
- Volunteers
- 200,000 people
- Sponsor
- Carmel Medical Center
Microbial Colonization, Dysbiosis
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
The aim of this study is to determine the efficacy of an oral nutraceutical with probiotics in restore vaginal health.
- Conditions
- Microbial Colonization, Dysbiosis, Fertility Issues
- Trial name
- PROSALVAG (NCT05176535)
- Testing
- FertyBiotic Balance
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fertypharm
Otitis Media, Suppurative Chronic, Cholesteatoma
Chronic Suppurative Otitis Media Microbiology
This study is planned to reveal the microbiological agents and drug sensitivities to these agents in patients diagnosed with chronic suppurative otitis media who complain of ear discharge.
- Conditions
- Otitis Media, Suppurative Chronic, Cholesteatoma, Microbial Colonization
- Trial name
- NCT06424704
- Testing
- Microbiological culture
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Selcuk University
Hand Eczema, Foot Eczema
Treatment of Staphylococcus Aureus Colonization in Hand Eczema
Atopic dermatitis is a chronic disease characterized by itching and eczematous lesions. In adults, eczema commonly localizes to the hands or feet.
- Trial name
- NCT01591785
- Testing
- Retapamulin 1% ointment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gary Goldenberg
Infection, Bacterial
Colonization of Bile Ducts and Infectious Complications in Cephalic Duodenopancreatectomy
Cephalic duodenopancreatectomy is part of the curative treatment for pancreatic cancer of the head and peri-ampullary area. The mortality of the procedure is around 5%, with a morbidity ranging from 30 to 50%.
- Trial name
- NCT04555252
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
MRSA-Colonization
Whole Body Washing With Chlorhexidine for the Eradication of MRSA
The purpose of this study is to determine whether whole body washing with chlorhexidine in combination with mupirocine nasal ointment is effective in the eradication of meticillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT00266448
- Testing
- Chlorhexidine solution 4%
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Microbial Colonization and Colorectal Disease
The Association Between the Microbiological Environment in Colon and Colorectal Disease
Colorectal illness contributes significantly to the global burden of disease. Cancer, inflammatory bowel disease and diverticulosis result in substantial patients suffering and health care expenditures.
- Trial name
- NCT03302715
- Testing
- Mucosal tissue sampling
- Volunteers
- 1,257 people
- Sponsor
- Karolinska Institutet
C-Section
Influence of Probiotics on Early Gut Microbial Colonization
The goal of this clinical trial is to learn whether daily probiotic drops plus vitamin D3 can improve early gut microbiome colonization in healthy infants born by C-section. It will also assess safety and tolerability.
- Trial name
- STORKIE (NCT07608341)
- Testing
- Probiotic drops
- Where
- 2 sites in Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- BioGaia AB
Nasal Polyps, Staphylococcus Aureus
Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP
Hypothesis: The investigators hypothesize that in patients with CRSwNP who demonstrate sinus colonization with staphylococcus aureus, the administration of dupilumab will be associated with decreased staph colonization and an…
- Trial name
- NCT05094570
- Testing
- Dupilumab Prefilled Syringe
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Microbial Colonization
Effect of Pea Fiber Supplementation on the Gut Microbiota and Host Metabolome and Proteome (FIB)
All subjects will complete a 49-day, multi-phase feeding study to evaluate the effect of pea fiber supplementation on gut community structure and features of host biological state (plasma proteome/ metabolome).
- Trial name
- FIB (NCT04159259)
- Testing
- Low fiber diet, Pea Fiber Bar
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Microbial Colonization, Eye Diseases
Assessment of the Ocular Microbiome in Health and Disease
The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment.
- Conditions
- Microbial Colonization, Eye Diseases, Ophthalmopathy
- Trial name
- NCT05414994
- Testing
- Eye swab
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bacterial Contamination of Physician Attire
Bacterial Contamination of Workwear
Governmental agencies in the United Kingdom and Scotland have recently instituted guidelines banning physicians' white coats and wearing of long-sleeved garments to decrease hospital transmission of bacteria.
- Trial name
- NCT01192841
- Testing
- Physician uniform
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Maturation of the Healthy Infant Intestinal Microbiota, Microbial Colonization
Bern Birth Cohort / Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach
Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life.
- Conditions
- Maturation of the Healthy Infant Intestinal Microbiota, Microbial Colonization, Nutrition Disorder, Infant, Milk Expression, Breast
- Trial name
- BeBiCo (NCT04447742)
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fatigue Syndrome, Chronic, Microbial Colonization
Intestinal Microbiota and Chronic Fatigue Syndrome
Gut microbiota of 1) patients with chronic fatigue syndrome and 2) their healthy family members are analyzed. Up to 40 patients with chronic fatigue syndrome are randomized to receive either 1) a faecal transplant from a healthty…
- Trial name
- NCT04158427
- Testing
- Faecal transplantation
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Tampere University Hospital
Staphylococcus Aureus Infection, MSSA Colonization
Photodisinfection for the Decolonization of Staphylococcus Aureus in Hemodialysis Patients
The purpose of the study is to evaluate whether PDT (MRSAid™) is effective in eradicating SA from hemodialysis patients who are known to harbor this organism inside their nose.
- Trial name
- NCT02741869
- Testing
- photodynamic therapy (Ondine: MRSAid™)
- Sponsor
- McMaster University