Clinical trials: Colorectal Disorders
Colorectal Cancer
Evaluation of Serum Tumor Endothelial Marker1 as a Potential Biomarker for Colorectal Cancer Diagnosis and Cancer Progression
Aim of work 1. measurement level of serumTEM1 in CRC patients by ng/ml using ELISA kits . 2. find relation between serum TEM1 level and staging of CRC patients . 3.
- Trial name
- NCT05779553
- Testing
- Tumor Endothelial Marker 1 ( TEM1 ) by ELISA kits
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colorectal Cancer, Tumor
Microbiome in Colorectal Cancer Onset and Progression
This is an observational study with the goal to improve the robustness of the scientific evidence linking Fusobacterium nucleatum (Fn) and/or other microorganisms to colorectal cancer (CRC) onset and/or progression.
- Conditions
- Colorectal Cancer, Tumor, CRC, GI Cancer
- Trial name
- NCT05368688
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Viome
Colorectal Cancer, Advanced Adenocarcinoma
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
This study was a prospective analysis conducted by Geneoscopy Inc. to evaluate the ColoSense test, which is a multi-target stool RNA test for colorectal cancer screening.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Serrated Polyp
- Trial name
- CRC-PREVENT (NCT04739722)
- Testing
- ColoSense
- Where
- 2 sites in United States
- Volunteers
- 14,263 people, healthy volunteers welcome
- Sponsor
- Geneoscopy, Inc.
Colorectal Cancer (CRC) Screening
Smartphone-enabled Hybrid Identification of Early CoLorectal Disease Using Blood-Based Cancer Testing Across TeXas
The goal of this prospective implementation study is to understand the impact of a blood-based screening test (BBST) for colorectal cancer (CRC) on patient acceptability of and adherence to CRC screening as well as the rate of…
- Trial name
- SHIELD-TX (NCT07398456)
- Testing
- Educational Information via Smartphone App
- Where
- United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Colorectal Cancer
Telemark Polyp Study, a Trial on Colonoscopy Screening
Colonoscopy screening to reduce mortality and incidence of colorectal cancer (CRC) has been implemented in many western countries. The estimated effect is based on case-control and observational studies.
- Trial name
- TPS (NCT01014039)
- Testing
- Flexible Sigmoidoscopy Screening arm
- Where
- Norway
- Volunteers
- 1,433 people, healthy volunteers welcome
- Sponsor
- Norwegian Department of Health and Social Affairs
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Colonic Polyp, Colon Cancer
Improving Outpatient Colonoscopy Bowel Prep With the Orton Score
Colonoscopy is a common endoscopic procedure which the UVA Gastroenterology \& Hepatology department performs on a daily basis for both screening/surveillance and diagnostic/therapeutic intent.
- Trial name
- NCT04093557
- Testing
- Orton Score, Typical Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer Risk, Ovarian Cancer Risk
Population Based Germline Testing for Early Detection and Prevention of Cancer
PROTECT-C is a research study offering genetic testing to people to see whether they have a genetic change that increases their risk of breast, ovary, bowel, and/or womb cancer.
- Conditions
- Breast Cancer Risk, Ovarian Cancer Risk, Cancer Gene Mutation
- Trial name
- PROTECT-C (NCT07498829)
- Testing
- Genetic testing for Cancer Susceptibility Genes (CSGs) (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6) and personalised breast and ovarian cancer risk
- Where
- United Kingdom
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Prostate Cancer
Cultured Circulating Tumor Cells in Prostate and Other Cancers
The purpose of this study is to evaluate the number of circulating tumor cells (CTC) before and after treatment using an experimental method for detecting CTC, compared to commercial CTC assay results, in patients with prostate…
- Trial name
- NCT02123862
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Oscar Goodman, Jr.
Hepatocellular Carcinoma, Glioblastoma
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
The primary objective of this study is to evaluate the safety and clinical activity of NKG2D-based CAR-T cells infusion in the treatment of relapsed/refractory NKG2DL+ solid tumors.
- Conditions
- Hepatocellular Carcinoma, Glioblastoma, Medulloblastoma, Colon Cancer
- Trial name
- NCT04270461
- Testing
- NKG2D-based CAR T-cells
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jiujiang University Affiliated Hospital
Digestive Tract Diseases, Liver Diseases
Tongue Image Database and Diagnostic Model for Digestive Tract Disease Diagnosis
The tongue images of patients with gastrointestinal diseases and healthy people will be collected and the tongue image database will be established.
- Conditions
- Digestive Tract Diseases, Liver Diseases, Colorectal Disease, Gastric Diseases
- Trial name
- NCT05182983
- Testing
- Tongue images，coating on the tongue and clinical data
- Where
- China
- Volunteers
- 10,690 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Cancer, Breast, Cancer, Colon
Enhancing Cancer Prevention and Control Pathways-Native Health Initiative
There are continued disparities in cancer incidence, mortality, and survival between American Indians (AIs) and Whites on cancers responsive to early screening (i.e., breast, colorectal, and cervical) in the US.
- Conditions
- Cancer, Breast, Cancer, Colon, Cancer, Cervix
- Trial name
- NCT04259762
- Testing
- Aim 8 (INT, Pilot Test): Breast, Colorectal, and Cervical Cancer Screening Cognitive-Behavioral Interventions
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance
Breast Cancer, Colorectal Cancer
Population-Based Patient-Centric Care: Comprehensive Preventive Cancer Screening Using Health IT
Although there is considerable evidence that current health IT can improve certain elements of care, the most effective and efficient implementation of health IT systems for primary care population management are not currently…
- Conditions
- Breast Cancer, Colorectal Cancer, Cervical Cancer
- Trial name
- TopCare (NCT01372527)
- Testing
- TopCare: Use of provider knowledge vs. automated system
- Where
- United States
- Volunteers
- 103,870 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Colorectal Adenoma
To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas
The risk of CRC in families of patients with CRC is well established, but it is less well-defined for families of patients with adenomas.
- Trial name
- NonAA (NCT02521727)
- Where
- 2 sites in Hong Kong
- Volunteers
- 828 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Neoplasms
Study of Fecal Bacteria in Early Diagnosis of Colorectal Cancer
The aim of the study is to identify and verify one or more gut bacteria of which the abundance in feces may help to early diagnosis colorectal cancer.
- Trial name
- NCT02845973
- Testing
- gut microbiota
- Where
- China
- Volunteers
- 1,325 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colo-rectal Cancer
Plasma-based Colorectal Cancer Screening Research & Development
The objective of this Clinical Sample Collection Study is to develop a biobank of appropriately collected plasma samples from colorectal cancer patients (i.e.
- Trial name
- NCT04027790
- Testing
- Epi proColon
- Where
- 5 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter
Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers
This randomized clinical trial studies the Family Caregiver Palliative Care Intervention in supporting caregivers of patients with stage II-IV gastrointestinal, gynecologic, urologic and lung cancers.
- Conditions
- Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter, Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT01846520
- Testing
- educational intervention, telephone-based intervention, quality-of-life assessment
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Cancer Screening, Diabetes Mellitus, Type 2
Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
This mixed methods study evaluates the effectiveness and feasibility of a multi-level (patient, team, organizations) intervention to optimize CRC screening for patients with diabetes in primary care safety-net settings.
- Trial name
- NCT05785780
- Testing
- Targeted CRC Screening Toolkit
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Adenoma, Adenoma Colon
Impact of AI on Trainee ADR
Adenoma detection rate (ADR) is a validated quality metric for colonoscopy with higher ADR correlated with improved colorectal cancer outcomes.
- Conditions
- Adenoma, Adenoma Colon, Colorectal Cancer
- Trial name
- NCT05423964
- Testing
- AI use in Endoscopy Room, Non-AI use Standard of Care endoscopy room
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Human Papillomavirus Infection
A Study to Evaluate the Immunogenicity and Safety of HPV Vaccine in Healthy Female Participants Aged 9-26 Years in China
The study is to evaluate immune response induced by 9-valent HPV study vaccine is non-inferior to those induced by GARDASIL® 9 administrated with 3-dose schedule in female participants aged 20-26 years in China, if the immune…
- Trial name
- NCT05662020
- Testing
- Recombinant Nonavalent (types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia coli), GARDASIL® 9
- Where
- China
- Volunteers
- 2,750 people, healthy volunteers welcome
- Sponsor
- Beijing Health Guard Biotechnology, Inc
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