Clinical trials: Comorbidity
PTSD
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities
Dr. Wang's merit review is aimed at providing a better understanding of the relationship between SLC6A3/SLC6A4 and the mental health of veterans exposed to high levels of combat stress, specifically focusing on PTSD symptoms…
- Trial name
- MTG (NCT00403455)
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Dengue Fever
A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years)
Dengue fever is caused by an infection with the dengue virus. Vaccination with Dengue Tetravalent Vaccine (TDV) can help prevent dengue fever.
- Trial name
- NCT06579755
- Testing
- TDV
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Takeda
Attention Deficit Disorder With Hyperactivity, Developmental Coordination Disorder
Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD)
This study aims to establish and present the prevalence figures and demographics of the co-morbidity of ADHD and DCD. It further aims to design an exercise intervention, to be utilised in the management of the symptoms of both…
- Trial name
- NCT03595826
- Testing
- Neurostimulant pharmaceutical drugs
- Where
- South Africa
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Chronic Heart Failure, Diabetes Mellitus
Exploring Acceptance and Outcomes of an Online-based Self-management Support System in Chronic Illness
The aim of the USECARE project is to improve and test SENACA, an ICT-based self-management support system for chronically ill patients and informal caregivers. 60 end-users will be instructed to use SENACA for approx.
- Conditions
- Chronic Heart Failure, Diabetes Mellitus, Chronic Obstructive Pulmonary Disease, Special Orthopaedic Co-Morbidity After Hip/Knee Replacement
- Trial name
- USECARE (NCT02832739)
- Testing
- SENACA - ICT based self-management support system
- Where
- 2 sites in Israel, Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Failed Back Surgery Syndrome
Low Level Laser Therapy to Reduce Comorbidity in Spinal Surgery
Each year, more than one million individuals worldwide are submitted to laminectomies, with a failure rate higher than 40%. Postlaminectomy epidural adhesion is implicated as a main cause of ''failed back surgery syndrome'' and…
- Trial name
- LASPINE (NCT02529657)
- Testing
- Low Level Laser Therapy
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Chronic Kidney Diseases
Uremic Toxins and Outcomes in Chronic Kidney Disease
The aim of this cohort study is: To investigate the etiology and epidemiology of comorbidities in CKD; To find out risk factors associated with the mortality of CKD; To find out uremic toxins which are related to the mortality…
- Trial name
- NCT03711617
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Erythropoietic Protoporphyria
Sorbent Therapy of the Cutaneous Porphyrias
The investigators demonstrated that cholestyramine is an effective binding agent in vitro for porphyrins. A few isolated case reports of treatment of individuals with a cutaneous porphyria suggest that cholestyramine and…
- Trial name
- EPP (NCT01422915)
- Testing
- Colestipol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression, Other Diagnoses, Comorbidities, and Complications
UTSW Depression Cohort: A Longitudinal Study of Depression
This is a longitudinal observational study (via electronic records and biospecimens) designed to utilize health IT advances to collect information from patients undergoing routine care.
- Trial name
- NCT02697487
- Testing
- No treatment
- Where
- United States
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Low Back Pain, Depression
Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions
The overall goal of this study is to use the National Health and Aging Trends Study (NHATS) data to gain an understanding of how multiple chronic conditions impact the health outcomes of older adults with back pain.
- Conditions
- Low Back Pain, Depression, Anxiety, Osteoarthritis
- Trial name
- NCT03632122
- Where
- United States
- Volunteers
- 8,344 people, healthy volunteers welcome
- Sponsor
- University of Washington
Influenza, Human
Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Underlying Medical Conditions
Evaluate the safety, immune response and reactogenicity of aH5N1 vaccination in adult (18 through 60 years of age) and elderly (≥61 years of age) subjects with and without underlying medical conditions.
- Trial name
- NCT02091908
- Testing
- Novartis Investigational H5N1 vaccine, Novartis Seasonal Influenza Vaccine
- Where
- 6 sites in Germany
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Seqirus
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Diabetes Mellitus, Hypertension
An International Prospective, Observational, Multi-centre Study on the Duration of Pre-operative Liquid Fasting
The investigators will be performing an international prospective, observational, multi-centre, cross-sectional study to determine the actual duration of preoperative liquid fasting time in European patients.
- Conditions
- Diabetes Mellitus, Hypertension, Ischaemic Heart Disease, Comorbidities and Coexisting Conditions
- Trial name
- THIRST (NCT06527703)
- Testing
- no intervention
- Where
- Malta
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Breast Cancer, Gastrointestinal Cancer
Improving Comprehensive Care of Cancer Patients
Cancer survivors have unique healthcare needs, including managing serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, and psychosocial support.
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Hematologic Cancer
- Trial name
- NCT05323409
- Testing
- OPTIMISE
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Heart Failure
MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY
The MAGIC-HF STUDY project (MAgna GraecIa evaluation of Comorbidities in patients with Heart Failure STUDY), is an observational prevalence and incidence study focusing on the role that risk factors, various comorbidities, and…
- Trial name
- MAGIC-HF (NCT05915364)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
To Reduce the LDL-C Level in Hypercholesteremia Adult Patients, Combination for Subgroup High LDL-c Patients With Other Comorbidities
Adult Subjects With Elevated Low-Density Lipoprotein-Cholesterol to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects
Objectives: The primary and secondary objectives of the study are presented below. Exploratory objectives are presented in the body of the protocol.
- Trial name
- NCT05905068
- Testing
- RN0191 INJECTION
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ikaria Bioscience Pty Ltd
HIV, Partner Violence
Improving South African Government Workers' Capacities to Deliver HIV Interventions
The purpose of this study is to address the United States Office of AIDS Research highest priorities: improving the workforce, reducing health disparities, and addressing HIV comorbidities.
- Conditions
- HIV, Partner Violence, Malnutrition, Alcohol Use/Abuse
- Trial name
- NCT02957799
- Testing
- Accountable Condition, Control Condition
- Where
- 2 sites in South Africa
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Migraine, Allergic Rhinitis
Is There a Comorbidity Between Migraine and Allergic Rhinitis?
The researchers investigated the relationship between migraine and allergy. For this purpose, the researchers designed a controlled study to evaluate nasal symptoms and signs; and to perform Specific Immunoglobulin E (IgE)…
- Trial name
- NCT01845051
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
COPD Patients, Healthy
Determinants of the Vascular Response to Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
Vascular comorbidities constitute a major burden in COPD patients. The atherosclerosis process is preceded by the onset of an endothelial dysfunction (assessed by the flow-mediated dilatation (FMD)), which is a risk factor for…
- Trial name
- cDysEndoBPCO (NCT03774238)
- Testing
- FMD analysis
- Where
- 2 sites in France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Obesity
Changes in Body Composition Following Bariatric Surgery
Obesity is an important public health issue worldwide. In the United States, the percentage of overweight and obese adults increased from 47 and 15%, respectively, to 69 and 36% in the last 40 years.
- Trial name
- NCT02148068
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Peter Nau
Comorbidity, Medication Therapy Management
Effectiveness of a Medication Wallet Card
This study evaluates whether or not the use of a medication wallet card in patients over 70 taking 5 or more medications promotes self-efficacy with regards to coping with illness, understanding medications, and staying healthy.
- Conditions
- Comorbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT02820129
- Testing
- Medication Wallet Card, Reminder Card
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University