Clinical trials: Comparative Effectiveness Study
Health Behavior
Hans Kai: Impact of a Peer Lead Community Health Program on Behavior Change, Mental Health, Health Efficacy and Social Support Comparative Control Study
To study the difference between participants interested in a lifestyle change when enrolled in Hans Kai or not when comparing behaviour change, social support, self health efficacy and mental health.
- Trial name
- NCT03450382
- Testing
- Hans Kai Education
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- NorWest Co-op Community Health
Head Lice, Pediculosis Capitis
A Clinical Trial to Evaluate Efficacy and Safety of a Water-soluble Head Lice Product.
The present study is set-up to compare in vivo clinical performance and safety of the test product versus an in the US commercially available, pyrethrum-based product (RID® shampoo).
- Trial name
- NCT03617926
- Testing
- X92001666
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Oystershell NV
Pain
Study of Pain Control With Hormonal IUS Insertion
This study aims to compare pain during insertion of the Skyla® IUS using a 100mm visual analog scale (VAS) among 92 young women aged 14 to 22 years randomized to receive a paracervical (n=46) block versus a sham paracervical…
- Trial name
- SOPHI (NCT02352714)
- Testing
- Paracervical Nerve Block
- Where
- 3 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Immunization
Study of TAK-816 in Healthy Infants
The purpose of this study is to evaluate the efficacy (immunogenicity) of TAK-816 when administered to healthy Japanese infants as multiple subcutaneous doses.
- Trial name
- NCT01379846
- Testing
- TAK-816+ DPT-TAKEDA, ActHIB+ DPT-TAKEDA
- Where
- 22 sites in Japan
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Takeda
Oral Hygiene, Dental Devices, Home Care
Evaluation of Plaque Removal Efficacy & Patient Acceptability of Knotted Floss Technique in Type II Gingival Embrasures
Removal and prevention of formation of dental plaque biofilms is the cornerstone of current hygiene regimens to prevent, reduce or even reverse the gingival and periodontal disease condition.
- Trial name
- KF-II (NCT03414073)
- Testing
- Knotted floss technique, Conventional flossing technique, Conventional Interdental Brushing
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Uttaranchal Dental & Medical Research Institute
Diagnosis Disease
Efficacy, Safety and Tolerability of a New Bowel Cleansing Preparation (BLI800) in Adult Subjects Undergoing Colonoscopy
The purpose is to demonstrate that BLI800 is non-inferior, on overall colon cleansing, to Fortrans® (a reference colonic lavage in China) administered in adult subjects scheduled to undergo a colonoscopy for a routinely accepted…
- Trial name
- EASY (NCT03562884)
- Testing
- BLI800, Fortrans®
- Where
- 10 sites in China
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Ipsen
Contraception, Healthy Female
Study of the Safety and Efficacy of Ulipristal Acetate (UPA) Used Daily as a Contraceptive
This is a Phase IIb multicenter, open-label, non-comparative trial of continuous daily oral 10 mg of ulipristal acetate (UPA) to evaluate its contraceptive efficacy as the primary method of contraception.
- Trial name
- CCN013B (NCT03296098)
- Testing
- Ulipristal acetate
- Where
- 18 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Premier Research
Dental Plaque Induced Gingivitis, Dental Plaque
A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
It is well accepted that the greatest contributor to the health of the periodontium and dentition is regular and thorough dental plaque removal, typically by means of adequate toothbrushing.
- Trial name
- NCT03416985
- Testing
- Oral B Healthy Clean Manual Toothbrush, BURST Sonic Oral Care, Philipps Sonicare DiamondClean 300 Series
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Irritable Bowel Syndrome
A Clinical Study to Determine the Safety and Efficacy of An Oral Probiotic Supplementation in the Management of Irritable Bowel Syndrome With Protein Digestion.
This is an open-label, two-arm, prospective, interventional, in-use safety and efficacy study of an oral probiotic supplementation in adult subjects having irritable bowel syndrome.
- Trial name
- NCT06687720
- Testing
- MetBroma
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Renal Disease
Comparative and Efficacy Study of ACTHar Gel Alone or in Combination With Tacrolimus in Fibrillary Glomerulopathy
Treatment with combination ACTHar gel and Tacrolimus therapy or ACTHar gel therapy alone in lowering urinary protein to creatinine (UP/Cr) ratios
- Trial name
- FACT (NCT04080076)
- Testing
- Acthar 80 UNT/ML Injectable Solution, Oral Tab Tacrolimus
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NephroNet, Inc.
IUD Insertion
Usability, Safety and Efficacy of AspivixTM
Limited mobility of the uterine cervix and alignment with the vaginal canal is often required during insertion of an intrauterine contraceptive device (IUD).
- Trial name
- NCT04441333
- Testing
- AspivixTM cervical vacuum tenaculum
- Where
- Switzerland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Aspivix SA
Contraception, Change in Bone Mineral Density
Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females
This study will be in two parts, Part A and Part B. The primary objective of Part A is to evaluate the contraceptive efficacy of LPRI-CF113.
- Trial name
- NCT05461573
- Testing
- Drospirenone
- Where
- 47 sites in United States, Canada
- Volunteers
- 1,542 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Focus: Estrogen-free Oral Contraception
Efficacy Study of Two Continuous Regimens of Oral Daily 5 mg or 10 mg of Ulipristal Acetate (UPA), Versus a Dose of 5.0mg UPA for 24/4 Days
To compare the pharmacodynamic effects of 2 continuous dose regimens of ulipristal acetate 5.0 and 10.0 mg-only oral contraception, versus a 24/4 day regimen of UPA 5.0 mg.
- Trial name
- CCN013 (NCT01953679)
- Testing
- Ulipristal Acetate
- Where
- 10 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Premier Research
Working Memory
Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy
This study is to investigate the efficacy of model-based Working Memory (WM) training using an appropriate control condition. The interventions are a model-based, a single-task and a multiple-task training on WM in order to…
- Trial name
- sMarT (NCT04042779)
- Testing
- model-based WM training, single-task WM training, multiple-task WM training
- Where
- Switzerland
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Relapsing Remitting Multiple Sclerosis
Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple Sclerosis
The goal of this prospective, multi-center, non-blinded, non-randomized, non-intervention clinical trial is to compare immunologic, virologic and epigenetic factors in patients with active multiple sclerosis in standard 2.line…
- Trial name
- CoSHEDRMS (NCT06159712)
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Female Stress Urinary Incontinence
Safety and Efficacy of Carbone Dioxide (CO2) Laser System in Treatment of Female Stress Urinary Incontinence.
This is a prospective, open-label, multi-center, non-comparative study that will be conducted on female subjects between 30 and 75 years of age, diagnosed with stress urinary incontinence (SUI).
- Trial name
- CO2 (NCT02981654)
- Testing
- Alma Lasers Pixel carbon dioxide laser system
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Androgenic Alopecia
An Exploratory Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Three Different Hair Growth Products in Patients With Mild to Moderate Androgenic Alopecia (Grade I to III)
This is an exploratory, prospective, three-arm, interventional, comparative, randomized, double-blind, placebo-controlled, safety, efficacy and in-use tolerability study of hair growth products in the patients mild to moderate…
- Trial name
- NCT06556056
- Testing
- SesZen-Bio Serum, Minoxidil hair serum (1%), Liposomal Form of SesZenBio
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Alopecia Areata
Comparative Study Efficacy and Safety of of Activated Versus Non-Activated PRP
This was comparative prospective study conducted on 40 subjects, diagnosed with alopecia areata of 40 the scalp, carried in a period from February 2020 and March 2021
- Trial name
- NCT05251831
- Testing
- Intradermal injection
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Forward Head Posture
Posture Correction Exercises for Forward Head Posture in Chronic Smartphone and Laptop Users
This study aims to compare different posture correction exercises to see which is most effective in improving forward head posture (FHP) in people who frequently use smartphones and laptops.
- Trial name
- Comparative (NCT06864780)
- Testing
- Posture Correction Exercises, Strengthening and Stretching Exercises
- Where
- Pakistan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Pelvic Pain Syndrome
Efficacy of Cognitive Behavior Therapy for Treatment of Chronic Pelvic Pain in Women
The study will employ 4 treatment arms and 1 placebo arm to compare efficacy of CBT, PFT, Pharmacotherapy, Integrated CBT and PFT modalities in the management of chronic pelvic pain in women.
- Trial name
- NCT07042555
- Testing
- CBT-cp, Pelvic Floor Therapy, Pharmacotherapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Islamia University of Bahawalpur