Clinical trials: Comparative Study
Healthy Volunteers
Fasting Comparative Bioavailability of Two Tablet Formulations of Levodopa /Benserazide in Healthy Volunteers
A group of 24 healthy volunteers receive one tablet of an association of levodopa 200 mg and benserazide 50 mg corresponding to two drug products: a test formulation (Evoser ®; Phoenix S.A.I.C.
- Trial name
- PHOE10903 (NCT01327261)
- Testing
- Levodopa + benserazide
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Buenos Aires
Influenza, Human
A Pilot Study to Evaluate the Safety and Immunogenicity of Low Dose Flu Vaccines
The purpose of this study is to determine whether low dose flu vaccines delivered with microneedles into the skin (intradermally) are effective.
- Trial name
- NANOVAX (NCT00558649)
- Testing
- Flu Vaccine (FLUARIX®)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- NanoPass Technologies Ltd
Pharmacokinetics
Phase I Study PK Study With OXP005 and Naprosyn
The Sponsor is developing a new form of naproxen (the study drug, OXP005), for the potential treatment of rheumatic and painful conditions.
- Trial name
- NCT02351024
- Testing
- OXP005, Naprosyn®
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Healthy Participants
Comparative Pharmacokinetics of SHR-8068 and Ipilimumab in Healthy Chinese Men
This phase 1 study compared the pharmacokinetics of a single intravenous dose of SHR-8068 injection with ipilimumab (YERVOY®) in healthy Chinese men. Safety and immunogenicity were also evaluated.
- Trial name
- NCT07852325
- Testing
- SHR-8068, Ipilimumab
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Bioavailability of Coenzyme Q10
Comparative Single-dose Bioavailability Study of Different CoQ10 Formulations
The single-center, randomized, open-label, five-period crossover single-dose bioavailability study with five CoQ10 formulations
- Trial name
- NCT04780074
- Testing
- Single dose intervention with Standard product (SP), Single dose intervention with Investigational product (IP1), Single dose intervention with Investigational product (IP2)
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Endometrial Cancer
A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Endometrial (uterine) cancer affects over 40,000 women each year in the United States. At this time there are no medications to prevent endometrial cancer. Women who are heavy are at increased risk of this cancer.
- Trial name
- NCT00161226
- Testing
- Levonorgestrel intrauterine system
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Musculoskeletal Injury
A Comparative Effectiveness Study of Two Interventions Aimed at Reducing Impact Loads in Runners
This study will use a comparative effectiveness design of two interventions known to reduce running impacts. The study will be conducted at the Spaulding National Running Center.
- Trial name
- NCT02987517
- Testing
- Increased running cadence gait retraining, Forefoot Strike gait retraining, Strengthening exercises
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Mandibular Fractures
Approaches for Open Reduction and Internal Fixation of Mandibular Condylar Fracture
The condylar region is the most frequent anatomical site for mandibular fractures . Condylar fractures constitute 25.5% to 35.5% of all mandibular fractures.
- Trial name
- NCT06333197
- Testing
- ORIF through transparotid approach, ORIF through retroparotid approach
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Adults
Comparative Study on Tolerance and Pharmacokinetics of Voriconazole for Injection in Healthy Subjects
A single intravenous drip of voriconazole for injection developed by Qilu Pharmaceutical (Hainan) Co., Ltd. and the original product "vfend" was given to healthy subjects ， The pharmacokinetic differences and tolerance of the two…
- Trial name
- NCT05330000
- Testing
- 4 mg/kg Voriconazole, 6 mg/kg Voriconazole
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Contraception
To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada)
The objective of the study is to compare the oral contraceptive (OC) SH T00658ID over Ortho Tri-Cyclen Lo administered for 13 cycles to healthy female volunteers between 18 and 50 years of age who request oral contraceptive…
- Trial name
- NCT00754065
- Testing
- Estradiol valerate, Dienogest (Natazia, Qlaira, BAY86-5027), Ortho Tri Cyclen Lo
- Where
- 59 sites in United States, Canada
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Bayer
Stress, Psychological
Comparative Intervention Study of Stress Reduction in Corporate Health Management
Aim of the study is the evaluation of the effects (psychological and physiological) of an hrv-biofeedback training, a mindfulness training and a combination of both training methods for stress reduction.
- Trial name
- NCT02709551
- Testing
- HRV_Bfb, MBI, MBI_HRV_Bfb
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
ST-Elevation Myocardial Infarction
Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches
This study investigates the effect of Colchicine in preventing heart structure changes following ST-segment elevation myocardial infarction.
- Trial name
- NCT06426537
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Indonesia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Healthy Participants
Riluzole Orodispersible Film Replicate Bioavailability
The objective of the study is to compare the pharmacokinetic profile of riluzole after replicate single dose of the novel orodispersible film test formulation and of the marketed reference Rilutek® tablets and to evaluate their…
- Trial name
- NCT04819438
- Testing
- Riluzole 50 mg orodispersible film, Rilutek® 50 mg riluzole tablets
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cross Research S.A.
Anesthesia, Local
PDL Anesthesia Versus Local Infiltration
The literature concerning the success and pain scores of PDL injection technique compared with other techniques remains controversial; whereas some studies found no significant difference in pain scores between local infiltration…
- Trial name
- PDL (NCT03173898)
- Testing
- PDL anesthesia versus local infiltration
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Breast Cancer
Fujifilm DBT Plus S-View Versus FFDM Alone in the Detection of Breast Cancer - A Pivotal Study
The purpose of the pivotal reader study is to assess the comparative accuracy of Fujifilm DBT plus S-View versus FFDM in the detection of breast cancer.
- Trial name
- NCT03501693
- Testing
- DBT plus S-View, FFDM Alone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujifilm Medical Systems USA, Inc.
Head Lice, Pediculosis Capitis
A Clinical Trial to Evaluate Efficacy and Safety of a Water-soluble Head Lice Product.
The present study is set-up to compare in vivo clinical performance and safety of the test product versus an in the US commercially available, pyrethrum-based product (RID® shampoo).
- Trial name
- NCT03617926
- Testing
- X92001666
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Oystershell NV
Myelofibrosis
Comparative Study on Pharmacokinetics of Two Formulations of Jaktinib in Healthy Adults Under Fasting Conditions
To evaluate the pharmacokinetic Characteristics of two formulations of Jaktinib Hydrochloride Tablets in Healthy Adult Volunteers
- Trial name
- NCT06132243
- Testing
- Jaktinib Hydrochloride Tablets
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Root Canal Treatment, Post Operative Pain
A First in Human Study to Compare Feasibility of Inertial Cavitation Irrigation to SNI in Root Canal Treatment.
The study design is a single-center 2-arm randomized controlled clinical trial. 10 subjects (teeth) requiring a root canal treatment will be enrolled in 2 groups (5 in each group).
- Trial name
- NCT05374434
- Testing
- Conventional irrigation, Inertial cavitation
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
Healthy
A Bioequivalence Study of Oseltamivir From Oseltamivir 75 mg Caps (Pharmacare PLC, Palestine) and Tamiflu® 75 mg Caps (Hoffmann-La Roche, Switzerland)
Comparative randomized, single dose, two-way crossover open-label study to determine the bioequivalence of Oseltamivir from Oseltamivir 75 mg capsules (Pharmacare PLC, Palestine) and Tamiflu® 75 mg capsules (Hoffmann-La Roche…
- Trial name
- NCT02507648
- Testing
- Oseltamivir, Tamiflu®
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genuine Research Center, Egypt
Diabetes, Hypertension
ACR | LAB Urine Analysis Test System Evaluation of Performance
The ACR LAB is a prescription-only, nurse- or clinician-conducted in vitro diagnostic (IVD) device. The test is for the qualitative and semi- quantitative detection of Albumin, Creatinine, and the Albumin-to- Creatinine Ratio.
- Trial name
- NCT04466501
- Testing
- ACR LAB
- Where
- 3 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Healthy.io Ltd.
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