Clinical trials: Compartment Syndrome of Leg
Acute Compartment Syndrome, Tibia Fracture
Biomarkers in the Diagnosis of Acute Compartment Syndrome
This prospective multinational, multicentre cohort study aims to investigate the hypothesis that biomarkers of muscle cell damage can predict acute compartment syndrome in patients with tibial fractures.
- Trial name
- BioFACTS (NCT04674592)
- Testing
- Blood samples and biopsies
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- University Hospital, Linkoeping
Compartment Syndrome of Leg
Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption
This study is a prospective, randomized trial. Our study aims to study the effects of perioperative patient education about compartment syndrome on patients' perception of their own pain, amount of opioid medication utilization…
- Trial name
- NCT03359031
- Testing
- Patient education
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Rothman Institute Orthopaedics
Acute Compartment Syndrome
Use of Near Infrared Spectroscopy to Detect Muscle Perfusion in the Lower Extremity of Uninjured Subjects
Acute compartment syndrome (ACS) is a complication of lower leg trauma that occurs when the pressure inside the leg due to swelling exceeds the body's ability to provide blood to the muscle of the leg.
- Trial name
- NCT01284023
- Testing
- Shaving
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
Compartment Syndrome
Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg
An investigation of a new catheter and pressure monitor system that may help to prevent a complication called compartment syndrome from developing in an injured leg.
- Trial name
- TS2 (NCT00681616)
- Testing
- Compartment Monitoring System (CMS), Compartment Monitoring System with Active Fluid Removal, Compartment Monitoring System without fluid removal
- Where
- 13 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Twin Star Medical, Inc.
Compartment Syndromes, Compartment Syndrome of Lower Leg
NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome
This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and…
- Conditions
- Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm
- Trial name
- NCT05672381
- Testing
- Lower extremity and/or upper extremity surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ischemia Limb, Blood Circulation Disorder
Ischemia Detection During Development of Acute Compartment Syndrome
This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide…
- Conditions
- Ischemia Limb, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- IDEA (NCT06079255)
- Testing
- IscAlert sensor(s) in patient with risk of acute compartment syndrome
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Compartment Syndrome
The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome
This study aims to determine how infrared spectroscopy compares to continuous compartment pressure monitoring in the detection of compartment syndrome.
- Trial name
- NCT00921271
- Testing
- Monitoring of StO2
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Acute Compartment Syndrome
The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers
The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured extremities over time.
- Trial name
- NCT01123798
- Testing
- near-infrared spectroscopy
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
Compartment Syndrome of Leg
Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A
Chronic Exertional Compartment Syndrome (CECS) is a painful condition affecting runners and it is caused by a reversible increase in pressure within a closed compartment in the leg.
- Trial name
- CECS (NCT05466539)
- Testing
- AbobotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Limb Ischemia
Evaluation of Acute Lower Limb Ischemia
The primary objective of this study is to evaluate the effect of different treatment modalities on clinical outcome of patients suffering from acute lower limb ischemia (ALI).
- Trial name
- PROMOTE-ALI (NCT05138679)
- Testing
- Revascularization, Primary major amputation, Best medical treatment
- Where
- 37 sites in Austria, Croatia and 8 more
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Compartment Syndrome of Leg
Botox for the Treatment of Chronic Exertional Compartment Syndrome
After diagnosis of Chronic Exertional Compartment Syndrome (CECS), the participants will be referred to both physical therapy and Botox injection.
- Trial name
- NCT03922139
- Testing
- OnabotulinumtoxinA Injection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Wisconsin, Madison
Compartment Syndrome of Leg
Evaluating the Diagnostic Performance of ACS Using NIRS in Traumatized Lower Extremities
This is a study intended to validate a new set of guidelines for a device that uses light to measure the amount of oxygen in the muscles of injured and non-injured legs and forearms in specific situations.
- Trial name
- NCT03604029
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Nonin Medical, Inc
Limb Ischemia, Compartment Syndrome of Leg
Chemical Analysis of Limb Microfluidics
Compartment syndrome (CS) is a condition where an increase in pressure in an anatomical compartment (e.g. the lower leg) affects the blood supply of the tissues, leading to tissue damage.
- Trial name
- CALM (NCT06050499)
- Testing
- Microdialysis catheter + biosensor
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Compartment Syndrome Nontraumatic Lower Leg
Physiotherapy or Fasciotomy as Treatment for Chronic Exertional Compartment Syndrome in the Lower Leg?
It is hypothesized that physiotherapy including a change in running landing pattern and surgical fasciotomy are equally good as treatment options for chronic exertional compartment syndrome (CECS) of the anterior compartment of…
- Trial name
- NCT03584815
- Testing
- Surgery/Fasciotomy, Physiotherapy
- Where
- 2 sites in Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Compartment Syndrome Nontraumatic Lower Extremity
The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics
During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site.
- Trial name
- HELP (NCT06036641)
- Testing
- NIRS monitoring, Laser Doppler flowmetry, Inflammatory and Oxidative stress biomarkers
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Portsmouth
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Acute Compartment Syndrome, Fracture, Bone
Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
The goal of this clinical trial is to learn if tissue ultrafiltration (TUF) catheters can reduce intramuscular pressure and prevent acute compartment syndrome (ACS) in adults ages 18-60 with severe proximal tibia or tibial shaft…
- Conditions
- Acute Compartment Syndrome, Fracture, Bone, Tibial Fractures
- Trial name
- NCT05889559
- Testing
- Tissue Ultrafiltration Catheters
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Major Extremity Trauma Research Consortium
Compartment Syndrome of Leg
Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome
10 participants with Recurrent Chronic Exertional Compartment Syndrome (R-CECS) will be enrolled in a 6 month study at the University of Wisconsin Hospitals and Clinics to test the hypothesis that injection of Botox into the…
- Trial name
- NCT05006417
- Testing
- Botox
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Wisconsin, Madison
Compartment Syndrome of Leg, Healthy
Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers
The goal of the study is to determine how different types of Regional Anesthesia (nerve blocks) can be helpful to patients with lower extremity trauma who develop compartment syndrome (an increased pressure in the fascial…
- Trial name
- NCT04113954
- Testing
- Mepivacaine Injection
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Femur Fracture
Natural History of Anterior Compartment Pressures of the Thigh Following Femur Fracture
This study is to determine the natural history of compartment pressures in the anterior thigh secondary to a fracture of the femoral shaft.
- Trial name
- NCT00919464
- Testing
- Pressure monitoring device, Compartmental fracture pressure monitoring, This small project is designed to be a non-randomized, investigational prospective trial of compartment pressures in the thigh following femoral fracture
- Volunteers
- 7 people
- Sponsor
- CAMC Health System