Clinical trials: Complication
Acute Pain, Postoperative, Regional Anesthesia Block
Dispersion Following ESP Versus ITP Blocks Using Lidocaine Study
Regional anesthesia techniques (or nerve blocks) are used to provide sensory blockade over the chest wall. The most established technique is thoracic epidural.
- Trial name
- DEVILS (NCT06843343)
- Testing
- Intertransverse Process Block with 1.5% Lidocaine, Erector Spinae Plane Block with 1.5% Lidocaine, 1.5% Lidocaine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Duke University
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Depression
Mother Matters Online Postpartum Support
Postpartum depression is common, yet only 20% of women seek treatment. Online support groups are a potential means of providing accessible mental health care during this time.
- Trial name
- NCT02953626
- Testing
- Mother Matters Online Postpartum Support Group
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Postoperative Pain
Liposomal Bupivacaine vs. Bupivacaine Hydrochloride and Lidocaine During Suburethral Sling Placement
Postoperative pain, the quality of their recovery and the opioid consumption following a midurethral sling placement are being compared between 2 groups.
- Trial name
- NCT02875015
- Testing
- Liposomal Bupivacaine, Bupivacaine Hydrochloride and Lidocaine, Suburethral Sling
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Preterm Infant, Full-term Infant
A Novel Parent Education Program for Early Intervention
One in ten infants born in the USA is born preterm before 37 weeks of gestation and 50% of those will have motor and cognitive delays requiring intervention at school age.
- Trial name
- NCT04266717
- Testing
- Baby Play Intervention, Milestone Education
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Postoperative Delirium
EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
- Trial name
- ALPHA-DEX (NCT04443517)
- Testing
- Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity
Effects of Two Hypocaloric Diets on Weight Loss
The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related…
- Trial name
- NCT01312740
- Testing
- LC-P-LGI diet, LC-CONV
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Esketamine, Pregabaline
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain.
- Conditions
- Esketamine, Pregabaline, Chronic Post Operative Pain
- Trial name
- NCT06117917
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Short Bowel Syndrome, Anticoagulation
Pharmacokinetics of Apixaban in Patients With Short Bowel Syndrome Requiring Long Term Parenteral Nutrition
Short bowel syndrome (SBS) is defined as a loss of function of the small intestine resulting in a malabsorptive disorder. In SBS, oral drug absorption may be altered due to extensive intestinal resection.
- Trial name
- ABSORB (NCT04344717)
- Testing
- Apixaban single dose, Apixaban steady-state
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian Cancer
Ovarian Cancer Individualized Scoring System Scoring System
This project aims at creating an individualized prognostic model using patient characteristics and disease features to determine disease prognosis using machine learning technology.
- Trial name
- OCISS (NCT05496517)
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fetal Alcohol Spectrum Disorder
Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy?
Urine sample and exhaled Nitric Oxide will analyzed and compared between children diagnosed with Fetal Alcohol Spectrum Disorder and healthy control. Pilot study- 5 children in each group
- Trial name
- NCT03802708
- Testing
- Metabolomic analysis urine sample
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Post-operative Pain, Acute, Cesarean Section
Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator
Post-cesarean section (CS) pain is commonly treated with acetaminophen, ibuprofen, and opioid medications as needed following delivery.
- Conditions
- Post-operative Pain, Acute, Cesarean Section, Opioid Use Disorder, Opioids; Harmful Use
- Trial name
- NCT06434714
- Testing
- Auricular percutaneous nerve field stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Infertility, Infertility, Female
Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes
Frozen embryo transfer (FET) cycles have become more common in recent years due to a push towards elective single embryo transfer (SET).
- Conditions
- Infertility, Infertility, Female, IVF
- Trial name
- ProFET (NCT04170517)
- Testing
- Measurement of serum progesterone on the day of FET
- Where
- United Kingdom
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- CARE Fertility UK
Periodontal Disease, Preterm Birth
Periodontal Disease and Preterm Birth
To determine the relationship between periodontal disease and upper genital tract inflammation in pregnancy. To determine whether certain fluid levels in the oral cavity and the vagina are associated with preterm birth or…
- Conditions
- Periodontal Disease, Preterm Birth, Low Birth Weight
- Trial name
- NCT00582374
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Arginine Vasopressin Deficiency, Primary Polydipsia
Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP…
- Trial name
- URANOS (NCT05890690)
- Testing
- Urea
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Diseases, Acute Myocardial Infarction
Troponin Excretion in Urine in Patients With and Without Chronic Kidney Disease
In this study, in order to better understand the mechanism of troponin clearance and the reason for elevated troponin levels in patients with CKD, we aim to evaluate quantitatively the excretion of troponin in the urine in…
- Trial name
- NCT04211610
- Testing
- Blood and urine sampling
- Where
- Israel
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Premature, Behavior, Child
Effects of Oriental Music on Preterm Infants
The goal of this study is to explore the effect of oriental music on premature infants' physiological and behavioral parameters during their hospital stay in the NICU.
- Trial name
- NCT04565210
- Testing
- Music exposure, Silence
- Where
- Lebanon
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Venous Malformation
Complications of Ethanol-amine Oleate Intralesional Sclerotherapy
The aim of this study is to clarify complications of Ethanolamine Oleate intralesional injections of maxillofacial venous formations in pediatric patients
- Trial name
- NCT04930952
- Testing
- Ethanol-amine Oleate Sclerotherapy Injection
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Magnetic Resonance Imaging, Vascular Complications
Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI
Allotransplants of vascularized composite tissues are subject to chronic vascular rejection, which can lead to graft loss. Currently, no imaging technique allows a reproducible quantitative exploration of the arterial trees of…
- Conditions
- Magnetic Resonance Imaging, Vascular Complications, Transplantation, Radial Artery
- Trial name
- FLOWHAND (NCT04257747)
- Testing
- MRI acquisitions, Doppler ultrasound procedure
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Third Molars Extraction
The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications…
- Trial name
- NCT07761338
- Testing
- Third molar
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
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