Clinical trials: Complication
Postoperative Pain, Cesarean Section
Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section
The purpose of this study is to compare the effectiveness of local wound infiltration of EXPAREL® (liposomal bupivacaine) with bupivacaine HCl compared to active control with bupivacaine HCl alone following elective primary or…
- Trial name
- NCT04232306
- Testing
- Liposomal bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Skin Graft Complications
Study to Assess the Safety and Efficacy of DERMASEAL for the Treatment of Split-Thickness Skin Graft Donor Site Wounds
The goal of this study to determine whether the combination biologic/drug DERMASEAL will safely decrease donor wound pain after split-thickness skin graft surgery.
- Trial name
- NCT06134843
- Testing
- DERMASEAL
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hobart W. Harris
Ovarian Diseases, Ovarian Neoplasms
Cancer Screening Program for Women at High Risk for Developing Ovarian Cancer
The main purpose of this program is to see whether periodically measuring CA-125 (tumor marker) levels in the blood and undergoing transvaginal ultrasounds over time will be effective in the early detection of ovarian cancer.
- Trial name
- OCEDP (NCT01292733)
- Testing
- Laboratory Tumor Marker Analysis, Transvaginal Ultrasound, Health Status Questionnaire
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Urinary Retention Postoperative, Arthropathy of Knee
Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty
Various studies have shown that the risk of suffering a urinary retention after knee or hip prosthesis surgery is 10-80%. The aim of the study is to reduce this riks.
- Conditions
- Urinary Retention Postoperative, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT03808155
- Testing
- Tamsulosin
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Graubünden
Urinary Incontinence
Effectiveness of Pelvic Floor Muscles Training in Group for Women With Urinary Incontinence
The aim of the study is to compare the efficacy of a protocol, pelvic floor muscle training (PFMT), applied in a group and at home for urinary incontinence (UI) in women.
- Trial name
- NCT03500185
- Testing
- PFMT in group, PFMT at home
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Recurrent Early Pregnancy Loss, Thyroid Diseases
Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women
The goal of this clinical trial is to investigate the influence of thyroxine supplementation on pregnancy outcomes in women with varying levels of Thyroid-Stimulating Hormone (TSH), who have experienced recurrent pregnancy loss…
- Trial name
- NCT06036576
- Testing
- Levothyroxine Pill
- Where
- Iraq
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Al-Kindy College of Medicine
Regional Anesthesia, Pain, Postoperative
Analgesic Efficacy of Single-shot Erector Spinae Block for Thoracic Surgery
The erector spinae plane (ESP) block is a novel regional anesthetic technique for the treatment of thoracic, cervical, and abdominal pain.
- Trial name
- AnESTh (NCT03419117)
- Testing
- ESP block
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetic Retinopathy
Augmenting Referral Pathway to Improve Uptake of Retinal Services by Diabetic Patients
Reiyukai Eiko Masunaga Eye Hospital (REMEH) is a non-profitable organization. Retina services were resumed from October 2019. Until this retinal service started, it has been mostly cataract-focused.
- Trial name
- NCT04829084
- Testing
- Pre-post educational intervention
- Where
- Nepal
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Seva Foundation
Atrophic Vaginitis, Vaginal Disease
Evaluation of Gynecological Acceptability of 3 Health Care Products
The research was conduct with 3 different products for use in the intimate region in up to 70 research participants, that use the investigational product by 35 ± 2 days.
- Trial name
- NCT04327947
- Testing
- Hyaluronic acid - Research product 1, Hyaluronic acid - Research product 2, Hyaluronic acid - Comparator product
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Herbarium Laboratorio Botanico Ltda
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Gestational Diabetes
Immediate Postpartum Glucose Tolerance Testing
The objective of this study is to compare the accuracy of a 2hr glucose tolerance test administered during the postpartum hospitalization with the standard of care glucose tolerance testing (administered at 6 weeks postpartum).
- Trial name
- NCT04199676
- Testing
- Glucose tolerance test
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Nephrotic Syndrome, Infections
The Predictive Value of Dynamic Changes of CD4+T Lymphocytes in Primary Nephrotic Syndrome With Infection
The goal of this observational study is to test whether the dynamic changes of CD4+T lymphocytes can predict infections in patients with primary nephrotic syndrome .
- Conditions
- Nephrotic Syndrome, Infections, Lymphocyte
- Trial name
- NCT05623033
- Testing
- The study is an observational study without intervention
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Premature Birth of Newborn
Supporting and Enhancing NICU Sensory Experiences (SENSE)
Seventy preterm infants born less than or equal to 32 weeks gestation were put into either the sensory-based intervention (experiment) group or traditional care (control) group. Consecutive admissions at St.
- Trial name
- SENSE (NCT03316547)
- Testing
- SENSE Program
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Preterm Birth, Immunologic Activity Alteration
Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model
This study investigates immunological and clinical markers in threatened preterm birth aiming to create a prediction model for preterm birth.
- Trial name
- NCT03796949
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Relapsing Remitting Multiple Sclerosis (RRMS), Malnutrition or Risk of Malnutrition
The Prevalance of Malnutrition and Its Association With Disability in Patients With Relapsing-Remitting Multiple Sclerosis
This prospective observational study aims to determine the prevalence of malnutrition in patients with relapsing-remitting multiple sclerosis and to evaluate its association with disability.
- Trial name
- NCT07497126
- Where
- Turkey (Türkiye)
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Infertility, Female, Microbial Colonization
Whether Vaginal Microbiota Affects Pregnancy Outcomes After Embryo Transfer
The goal of this observational study is to learn about vaginal microbial characteristics in the patients under in vitro fertilization treatment.
- Trial name
- NCT06296615
- Where
- China
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Postsurgical Pain, Third Molar Extraction
Efficacy and Safety of APSCTC for the Treatment of Postsurgical Pain Due to Third Molar Extraction
The purpose of this study is to evaluate the efficacy of APSCTC compared to two active drugs in acute pain relief.
- Trial name
- CARLOTA (NCT04647435)
- Testing
- APSCTC, Toragesic®, Tramal®
- Where
- Brazil
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- Apsen Farmaceutica S.A.
Polycystic Ovary, Progesterone Resistance
Progesterone Action on Endometrium of PCOS
Objective: To study the influence of metabolic factors on the action of progesterone on the endometrium of women with PCOS. Design: A prospective open-label clinical trial.
- Trial name
- NCT05062135
- Testing
- Progesterone 400 Mg Vaginal Suppository on PCOS
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
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