Clinical trials: Complication of Dialysis
Intradialytic Hypotension, End Stage Renal Disease
Application of Impedance Threshold Device Technologies to Treat and Prevent Hypotension During Dialysis
The purpose of this study is to evaluate the application of the impedance threshold device during hemodialysis in children to optimize fluid removal, reduce the incidence of complications (such as cramps,vomiting and…
- Conditions
- Intradialytic Hypotension, End Stage Renal Disease, Low Blood Pressure
- Trial name
- ITD (NCT00576524)
- Testing
- ITD
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Children's Hospital of Philadelphia
Fungal Infection
Study of Cyclodextrin (SBECD) and Voriconazole Blood Concentrations During Continuous Dialysis
This study's primary objective is to determine if continuous renal replacement therapy (CRRT) can adequately remove the sulfobutylether-ß-cyclodextrin sodium (SBECD) vehicle from the blood so that intravenous voriconazole can be…
- Trial name
- NCT01101386
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Hypertension
VALID: Study to Compare the Reduction of Predialysis Systolic Blood Pressure With Valsartan Compared to Irbesartan in Patients With Mild to Moderate Hypertension on Long-term Hemodialysis
The purpose of the study is to compare the efficacy, safety and tolerability of valsartan 80 mg (with a starting dose of 40 mg) to irbesartan 150 mg (with a starting dose of 75 mg) in patients on long-term haemodialysis with mild…
- Trial name
- NCT00171080
- Testing
- valsartan, irbesartan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 86 people
- Sponsor
- Novartis
CKD (Chronic Kidney Disease) Stage 5D, Peritoneal Dialysis (PD)
The Effect of Exercise on Blood Pressure Variability on Peritoneal Dialysis Patients
In China, the chronic kidney disease (CKD) incidence rate is as high as 10.8%. Renal replacement therapy plays an critical role in the later stage of CKD and becomes mandatory, as end-stage renal disease (ESRD) is unavoidable in…
- Trial name
- NCT07098923
- Testing
- combination of aerobic and resistance exercise
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Iron Deficiency Anemia, Chronic Kidney Disease
Iron Isomaltoside 1000 (Monofer®) in Non-Dialysis Dependent Chronic Kidney Disease and With Renal-Related Anaemia
The study is designed to determine the effects of an investigational drug Monofer in subjects with non-dialysis dependent chronic kidney disease (NDD-CKD) subjects and with iron deficiency anaemia (IDA).
- Trial name
- NCT01102413
- Testing
- Monofer, Iron Sulphate
- Where
- Denmark
- Volunteers
- 351 people
- Sponsor
- Pharmacosmos A/S
Kidney Failure,Chronic
Safety, Effectiveness and Manipulability Evaluation of a Domestic PD Machine
This study is a randomized, multi-center，crossover study of a domestic FM peritoneal dialysis machine and Baxter HOMECHOICE.It aims to verify safety, effectiveness and manipulability of a domestic peritoneal dialysis machine.
- Trial name
- NCT02525497
- Testing
- FM peritoneal dialysis machine, HOMECHOICE peritoneal dialysis machine
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chinese PLA General Hospital
End Stage Renal Failure on Dialysis, End Stage Renal Disease on Dialysis
Human Factors Validation Testing for the Peripal System; a Manual Connection Assist Device for Peritoneal Dialysis Devices
It is estimated that there are currently over 3 million patients receiving dialysis treatment worldwide. With effective pre-dialysis counselling, a majority of patients choose the home-based therapy peritoneal dialysis (PD) but…
- Conditions
- End Stage Renal Failure on Dialysis, End Stage Renal Disease on Dialysis, Renal Failure, Peritoneal Dialysis
- Trial name
- NCT04292210
- Testing
- Perisafe
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Peripal AG
Hyperphosphatemia, End Stage Renal Disease
A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP
The study is designed to evaluate the ability of tenapanor alone or in combination with sevelamer to achieve serum phosphorus concentration (sP) within the population reference range (sP >2.5 and ≤4.5 mg/dL) in patients with…
- Trial name
- NORMALIZE (NCT03988920)
- Testing
- Tenapanor, Sevelamer Carbonate
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Ardelyx
End Stage Renal Disease
A Research Study for Patients With End-Stage Renal Disease (ESRD)
The purpose of this study is to evaluate the ability of a treatment strategy, that includes cinacalcet for the management of secondary hyperparathyroidism, to control parathyroid hormone (PTH) compared with the standard of care.
- Trial name
- NCT00110890
- Testing
- cinacalcet, Standard of care
- Volunteers
- 552 people
- Sponsor
- Amgen
End Stage Renal Failure on Dialysis, Hemodialysis Access Failure
Results of Cold Stored Allografts in Vascular Access
Vascular access creation in patients with renal failure requiring long-term hemodialysis can be a challenge when there is no more autologous material or in case of infection, in a population undergoing long term dialysis with a…
- Trial name
- RAVASC (NCT04446546)
- Testing
- Vascular access by pass using a cold stored venous allograft
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Renal Failure
Music Interventions for Patients Undergoing Hemodialysis
Fatigue is found to be one of the most persistent problems among patients in treatment with hemodialysis, and associated with impaired health-related quality of life.
- Trial name
- NCT04959682
- Testing
- Music Intervention
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Southern Denmark
Uremic Pruritus
A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session.
- Trial name
- NCT03422653
- Testing
- CR845 0.5 mcg/kg
- Where
- 57 sites in United States
- Volunteers
- 378 people
- Sponsor
- Cara Therapeutics, Inc.
Kidney Failure, Anemia
Iron Sucrose in Stage 3/4 Kidney Disease
One of the complications of late stage kidney disease is the development of a low red blood cell count (anaemia/low haemoglobin concentration).
- Trial name
- NCT00202345
- Testing
- Iron sucrose
- Where
- 6 sites in Australia
- Volunteers
- 120 people
- Sponsor
- Melbourne Health
Potassium Imbalance, Cardiac Arrhythmia
The Effect of Potassium Lowering Drugs on Cardiac Electrical Stability in Hemodialysis Patients (ART Study)
This study is a multicenter, prospective and randomized controlled study. The experiment includes a 1-week screening period (1 week before dialysis) and a 7-week treatment period (1-4 weeks of dose drip period and 5-7 weeks of…
- Conditions
- Potassium Imbalance, Cardiac Arrhythmia, Dialysis; Complications
- Trial name
- NCT06242041
- Testing
- sodium zirconium cyclic silicate
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University First Hospital
Pre-dialysis, End Stage Renal Disease
NESP Pediatric Study
Open-label, randomized study of NESP in pediatric subjects 18 years of age or younger. Subjects will receive study drug (NESP or rHuEPO) for 28 weeks after a 2 week screening and baseline period.
- Trial name
- NCT00527137
- Testing
- darbepoetin alfa, rHuEPO
- Volunteers
- 120 people
- Sponsor
- Amgen
Renal Insuffiency, Kidney Transplantation
Pre-emptive Kidney Transplantation Quality of Life
The main objective is to assess the psychological impact of pre-emptive kidney transplantation on patients' quality of life taking into account psychological adjustment (response shift), compared to patients who have experienced…
- Trial name
- PreKiTQoL (NCT02154815)
- Testing
- Questionnaires : Patient-Reported Outcomes
- Where
- 5 sites in France
- Volunteers
- 390 people
- Sponsor
- Nantes University Hospital
End Stage Chronic Renal Failure
Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment
Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption.
- Trial name
- PREFDOM (NCT07535320)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Kidney Disease, Chronic, Renal Transplant Failure
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relatively new class of agents, originally developed as oral antihyperglycemic drugs.
- Conditions
- Kidney Disease, Chronic, Renal Transplant Failure, Heart Failure, Kidney Failure
- Trial name
- NCT05374291
- Testing
- Dapagliflozin 10 mg/day (oral)
- Where
- 101 sites in Australia, Belgium and 4 more
- Volunteers
- 1,750 people
- Sponsor
- University Medical Center Groningen
Renal Insufficiency, Chronic
Effects by Omission of Bandage Over Exit Site
Peritoneal dialysis, known as p- dialysis (PD), is a dialysis form in which the blood is purified by using the body's peritoneum. PD dependents on good access to peritoneum.
- Trial name
- EXIT (NCT02102425)
- Testing
- Patients with or without bandage over exit site
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Edith Mark
End-stage Renal Disease
Vitamin D and Arteriovenous Fistulae
Patients requiring hemodialysis following kidney failure need a form of dialysis vascular access in order to undergo the dialysis procedure. Dialysis vascular access dysfunction is an enormous clinical problem.
- Trial name
- NCT00912782
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Emory University
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