Clinical trials: Comprehension, open to volunteers
Ophthalmic Disease, Artifical Intelligence
Evaluating AI-Generated Plain Language Summaries on Patient Comprehension of Ophthalmology Notes Among English-Speaking Patients
This clinical trial is testing whether plain language summaries made by artificial intelligence help people understand their eye doctor's notes better.
- Conditions
- Ophthalmic Disease, Artifical Intelligence, Large Language Model
- Trial name
- NCT06859216
- Testing
- AI-Generated Plain Language Summaries
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes, Diabetes Type 2
Glucose, Understanding, Integrated Digital Health, and Engagement (GUIDE) Study
The purpose of this study is to evaluate whether an Integrated Digital Health (IDH) intervention with and without healthcare provider engagement, improves glycemic control and diabetes-related outcomes among adults with Type 2…
- Trial name
- GUIDE (NCT07689877)
- Testing
- Integrated Digital Health (IDH) platform, Provider engagement
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Yale University
Cigarette Smoking-Related Carcinoma
Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences
This clinical trial studies how the flavors and synthetic coolant properties in oral nicotine pouches (ONPs) compare to one another and how these characteristics are perceived by users.
- Trial name
- NCT07111234
- Testing
- Carbon Monoxide Measurement, Nicotine Oral Pouch, Questionnaire Administration
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Multiple Sclerosis
Medication Understanding in MS
The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home.
- Trial name
- MUMS (NCT07518381)
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Tuberculosis (TB)
Examining Psycho-Socioeconomic Linkages in TB Care: The UPLIFT Trial
Introduction: Tuberculosis (TB) remains an ongoing public health and socioeconomic challenge worldwide, especially in low- and middle-income countries such as Vietnam.
- Trial name
- UPLIFT (NCT06916962)
- Testing
- Intervention
- Where
- 12 sites in Vietnam
- Volunteers
- 1,324 people
- Sponsor
- Freundeskreis Für Internationale Tuberkulosehilfe e.V
Cerebro Vascular Disease
Clinico-radiological Correlations in Cerebro-VASCULAR Disease
This observational retrospective and prospective registry aims to explore the relationships between clinical manifestations and radiological findings in cerebrovascular diseases.
- Trial name
- NCT07493694
- Volunteers
- 1,143 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Understanding of Genetics by Men at Risk for Prostate Cancer
With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions.
- Trial name
- NCT04550845
- Testing
- Focus group analyses
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cochlear Synaptopathy
A Study Testing the Safety and Possible Benefits of an Ear Injection of a New Compound, Paliroden, in People With Type 2 Diabetes Who Have Difficulty Understanding Speech in Noisy Situations
Like retinopathy, neuropathy and nephropathy, sensorineural hearing loss is a common and underserved complication of uncontrolled diabetes.
- Trial name
- RESPLAND (NCT07472907)
- Testing
- CIL001 (Paliroden)
- Volunteers
- 135 people
- Sponsor
- Cilcare SAS
Surgery
FOCUS Pre-Post Study
The Facilitating Goal-based Conversations for Understanding Surgery (FOCUS) Guide is a communication intervention designed to support discussion and documentation of the goal for surgery during outpatient surgical consultations.
- Trial name
- NCT07664514
- Testing
- FOCUS Guide
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Utah
Financial Exploitation of Older Adults
Leveraging Behavioral Economics to Understand and Improve Financial Decision Making Among Vulnerable Older Adults
This study seeks to test novel informational content / nudge strategies to mitigate financial vulnerability among older adults.
- Trial name
- NCT07682740
- Testing
- Participants receiving informational self-nudges to improve financial decision-making, Control - Participants receiving informational content on healthy eating and physical activity
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Kidney Injury, Fluid Overload
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors
- Trial name
- AWAKEN 2 (NCT06823115)
- Where
- 125 sites in United States, Argentina and 31 more
- Volunteers
- 8,000 people
- Sponsor
- Indiana University
Opioid Tapering
Prescription Opioid Discontinuation: Honoring Patient Insights and Experience to Support Safe and Caring Transitions -- Decision Aid Pilot
Because of recent policies to decrease opioid use, some people using long-term opioid therapy (LTOT) are encouraged or required to stop (discontinue) taking opioids.
- Trial name
- PHOENIX (NCT07202026)
- Testing
- Patient-centered Decision Aid to support long-term opioid therapy tapering
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kaiser Permanente
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Hearing Loss, Cochlear Hearing Loss
Peripheral and Central Influences on Auditory Temporal Processing & Speech Perception in Older Cochlear Implantees
Older adults who use cochlear implants to address hearing loss show wide variation in benefit. This research investigates the role of normal aging, the health of peripheral and central auditory pathways, and positioning of the…
- Conditions
- Hearing Loss, Cochlear Hearing Loss, Hearing Loss, Sensorineural, Aging
- Trial name
- NCT05554692
- Testing
- Diagnostic tests of cochlear implant function, Diagnostic tests of auditory function
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Maryland, College Park
Mental Health, Substance Use (Drugs, Alcohol)
Understanding Psychological Distress and Therapeutic Environment in the Emergency Department
This research aims to establish the number of patients coming to Emergency Departments (EDs) with issues relating to mental health, alcohol or drugs, or in some form of psychological distress, including those for whom this was…
- Conditions
- Mental Health, Substance Use (Drugs, Alcohol), Psychological Distress
- Trial name
- UPDATE-ED (NCT06655467)
- Testing
- Routine Care
- Where
- United Kingdom
- Volunteers
- 398 people
- Sponsor
- NHS Fife
Hearing Impairment, Sensorineural, Spatial Perception
Understanding Aided Speech Perception in Noise
The overarching hypothesis to be evaluated using this protocol is that age-related hearing loss (ARHL) leads to shifts in the functional spatial boundaries between segregated and integrated auditory streams, and that hearing aid…
- Conditions
- Hearing Impairment, Sensorineural, Spatial Perception, Aging, Hearing Aids
- Trial name
- NCT06377215
- Testing
- Open-source master hearing aid
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Synchrony
Understanding Newborn-Mother Synchrony at Home: Feasibility of Remote Monitoring
Parents and newborns influence each other in a dynamic interaction that can be described as synchrony. Synchrony between a newborn and mother refers to the dynamic and reciprocal adaptation between the newborn and mother.
- Trial name
- NCT07392138
- Testing
- Using monitoring devices
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Turku