Clinical trials: Concussion, Mild Traumatic Brain Injury
Mild Traumatic Brain Injury, Alexithymia
Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury
The purpose of the study is to test two different training programs to find out which is better at helping people with a concussion or mild TBI (mTBI) improve their emotional health and well-being.
- Trial name
- NCT07436754
- Testing
- Program 1, Program 2
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Mild Traumatic Brain Injury, Headaches Posttraumatic
SMART Concussion Trial: Symptom Management vs Alternative Randomized Treatment of Concussion Trial
Given the rising rates of concussion in youth ages 10-19 and the significant proportion of young people who remain symptomatic for months following concussion, research evaluating the efficacy of multifaceted treatment options…
- Conditions
- Mild Traumatic Brain Injury, Headaches Posttraumatic, Neck Pain, Dizziness
- Trial name
- SMART (NCT05446597)
- Testing
- Symptom-specific Headache Treatment, Symptom-specific Dizziness &/or Neck Pain Treatment, Multimodal Concussion Treatment
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Concussion, Brain, Mild Traumatic Brain Injury
REhabilitation of MEMory Symptoms After BRain Concussion
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors.
- Trial name
- REMEMBR (NCT06956417)
- Testing
- Cognitive behavioral therapy, Cognitive rehabilitation
- Where
- 8 sites in Canada
- Volunteers
- 184 people
- Sponsor
- University of British Columbia
Mild Traumatic Brain Injury, Concussion
Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial
Mild traumatic brain injuries ("mTBIs") affect over 480,000 Canadians each year. While many individuals recover in the initial 4 weeks following mTBI, in up to 30% of individuals symptoms and functional impairments often persist…
- Trial name
- PIC Rehab (NCT07402733)
- Testing
- Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Sport Injury Prevention Research Centre
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Mild Traumatic Brain Injury (mTBI), Sports-related Concussion
Mobile Dual-Task Brain and Balance Intervention for Concussion Recovery
This research study examines recovery after a sports-related concussion or mild head injury. Many athletes experience lingering problems with thinking, balance, and mood months after a concussion.
- Conditions
- Mild Traumatic Brain Injury (mTBI), Sports-related Concussion, Heart Rate Variability (HRV), Walking
- Trial name
- NCT07599475
- Testing
- Home-Based Mobile Dual-Task Intervention (BraW-Day™)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hyunhwa Lee
Concussion, Mild Traumatic Brain Injury
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the acute period after concussion.
- Trial name
- Breathe - PED (NCT07572734)
- Testing
- Paced breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mild Traumatic Brain Injury
Recovery Among Older Adults Following Mild TBI
Among fall related injuries in older adults, head injuries are the most common, yet almost nothing is known about recovery from head injury, also known as traumatic brain injury or TBI, in this population.
- Trial name
- NCT07569354
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Maryland, Baltimore
Depression, Mild Traumatic Brain Injury
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans…
- Conditions
- Depression, Mild Traumatic Brain Injury, Concussion, Brain
- Trial name
- NCT05682677
- Testing
- iTBS, Personalized, Augmented Cognitive Training (PACT)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Post-Traumatic Headache, Concussion, Mild
GAIN Symptoms: Post-traumatic Headache
The overall aim of the study is to advance the knowledge on the characterization and underlying pathophysiological mechanisms of persistent post-traumatic headache (PTH) with a direct impact on the ability to diagnose and manage…
- Conditions
- Post-Traumatic Headache, Concussion, Mild, MTBI - Mild Traumatic Brain Injury
- Trial name
- NCT05857761
- Testing
- Active repetitive transcranial magnetic stimulation (rTMS)
- Where
- Denmark
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sleep Architecture, Mild Traumatic Brain Injury
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances.
- Conditions
- Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
- Trial name
- NCT07385105
- Testing
- Cognitive behavioral Therapy for insomnia (CBT-I)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Depressive Symptoms, Mild Traumatic Brain Injury
rTMS for Military TBI-related Depression
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in…
- Conditions
- Depressive Symptoms, Mild Traumatic Brain Injury, Concussion
- Trial name
- ADEPT (NCT05426967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 198 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Improving Cognitive Rehabilitation Outcomes
Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality…
- Trial name
- NCT07055633
- Testing
- CCT+MBLT, CCT+ION
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury; Concussion
CORE (Cognitive Optimization Through Rehabilitation and Education) Study
Mild traumatic brain injury (mTBI) affects millions of individuals worldwide every year. It has long been thought that the vast majority of individuals who sustain a mTBI experience natural recovery with little or no intervention…
- Trial name
- CORE (NCT06859996)
- Testing
- Tools for Rehabilitation and Cognitive Care (On-TRACC), Brain Health psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 354 people
- Sponsor
- University of Washington
Mild Traumatic Brain Injury, Suicidal Ideation
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicidal Ideation, Impulsivity
- Trial name
- NCT05647044
- Testing
- intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Alcohol Use Disorder, Mild Traumatic Brain Injury
rTMS Target Identification for Functional Disability in AUD+mTBI
The objectives of this VA Merit application are to identify a neural target unique to Veterans with co-occurring alcohol use disorder and mild traumatic brain injury (AUD+mTBI) and to test the efficacy of this target as a…
- Trial name
- rTMS-TARGET-ID (NCT04043442)
- Testing
- Magventure MagProX100 with MagOption stimulator and Magpro Cool Coil B65 A/P
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury, Concussion (Diagnosis)
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
Objectives: Approximately one-third of patients with concussion experience persistent symptoms that, in addition to causing serious discomfort, may lead to unemployment and other socioeconomic challenges.
- Trial name
- NCT06644131
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Southern Denmark
Mild Traumatic Brain Injury
Mobilizing Early Management of Mental Health Complications After Mild Traumatic Brain Injury
Mental health problems frequently complicate recovery from mild traumatic brain injury (mTBI) but are under-recognized and under-treated.
- Trial name
- M4 (NCT04704037)
- Testing
- Guideline implementation tool, Generic information about concussion management
- Where
- 9 sites in Canada
- Volunteers
- 537 people
- Sponsor
- University of British Columbia