Clinical trials: Concussion, Mild Traumatic Brain Injury
Traumatic Brain Injury, TBI
Walking After Traumatic Brain Injury in Older Adults
The purpose of this research is to learn if different behavioral interventions can change walking behaviors over 12-weeks, in older adults who have previously suffered a non-penetrating mild or moderate TBI.
- Conditions
- Traumatic Brain Injury, TBI, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
- Trial name
- NCT06222502
- Testing
- Planning, Reminders, and Micro-Incentives, Health Education
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Timothy Morris
Concussion, Mild, Concussion, Brain
The Exercise and Concussion Health Study
This study aims to investigate the effect of two different physical exercise interventions on the brain, cognition and patient reported outcomes following a mild traumatic brain injury (mTBI) in community-dwelling adults.
- Conditions
- Concussion, Mild, Concussion, Brain, TBI (Traumatic Brain Injury), TBI
- Trial name
- TECHS (NCT06494592)
- Testing
- Aerobic Exercise, Balance Exercise
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northeastern University
Insomnia, Mild Traumatic Brain Injury
Behavioral Insomnia Treatment in Mild Traumatic Brain Injury
This is a single site, two-armed random controlled trials (RCT) comparing six sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) with four sessions of Brief Behavioral Therapy for Insomnia (BBT-I) in service members…
- Trial name
- NCT06551987
- Testing
- Cognitive Behavioral Therapy for Insomnia, Brief Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Mild Traumatic Brain Injury (mTBI)
Implementation of Biomarker-Based Care for mTBI - IMPACTS-BRAINI Study
This study aims to evaluate the real-world applicability and clinical added value of a new management pathway for patients presenting to the emergency department (ER) with mild traumatic brain injury (mTBI).
- Trial name
- IMPACTS-BRAINI (NCT07311486)
- Testing
- GFAP and UCH-L1
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitario 12 de Octubre
Mild Traumatic Brain Injury
BRAINI-2 Elderly Mild TBI European Study
Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse.
- Trial name
- BRAINI2ELDER (NCT05425251)
- Testing
- GFAP and UCH-L1
- Where
- 7 sites in France, Germany and 1 more
- Volunteers
- 2,297 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario 12 de Octubre
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI
This study is a parallel arm, double-blind, randomized, controlled clinical trial to assess the safety and efficacy of an experimental software program designed to improve cognitive functions versus a computer-based software…
- Trial name
- CogMind (NCT02922569)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Mindfulness Training
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Posit Science Corporation
Mild Traumatic Brain Injury, Photophobia
Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury
The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in…
- Trial name
- NCT06109909
- Testing
- Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
MTBI - Mild Traumatic Brain Injury
Validation of Clinical Outcome Measures Specific to mTBI-Related Oculomotor Disorders
The specific aim of this project is to validate clinical tests to be used as outcome measures in studies of mTBI-related vision problems.
- Trial name
- NCT07282691
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Salus University
Mild Traumatic Brain Injury
Auditory Plasticity Training
The investigators are working on a project to help people who have had mild brain injuries hear better. Sometimes, these injuries can make it hard for people to hear clearly, especially in noisy places or when trying to tell…
- Trial name
- NCT06628505
- Testing
- Speech in Noise Training, Spatial Hearing Training Group, Spatial Hearing Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain Concussion, Mild Traumatic Brain Injury
Concussion Recovery and Support Program
Pilot randomized controlled trial (RCT) comparing a novel intervention Concussion Recovery and Support Program (CRISP) for adolescents and young adults (AYA) 18-29 yo with concussion/ mild TBI.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache
- Trial name
- CRISP (NCT07097792)
- Testing
- CRISP (Concussion Recovery and Support Program)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Mild Traumatic Brain Injury, Vestibular Neuropathy
Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation
The objective for this study is to compare outcome measures from vestibular rehabilitation (VPT) delivered in a traditional method against a new device Incremental Velocity Error (IVE) that improves physiologic performance of the…
- Trial name
- INVENT (NCT03846830)
- Testing
- Incremental Velocity Error (IVE), Traditional Vestibular Rehabilitation (VPT)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Brain Concussion, Brain Trauma
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS).
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- NCT04925453
- Testing
- active tDCS and cognitive training intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- United States Naval Medical Center, San Diego
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Mild Traumatic Brain Injury, Concussion, Rehabilitation
Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation
Current clinical assessment tools are often not sensitive enough to detect and treat some subtle (yet troubling) problems after mTBI.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Rehabilitation, Balance Impairment
- Trial name
- SuBTyPE (NCT06381674)
- Testing
- Vestibular therapy for mTBI augmented with audio and visual real-time biofeedback, Vestibular therapy for mTBI
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
mTBI - Mild Traumatic Brain Injury
MindRhythm Detection of Concussion and Recovery Study
This study is designed to observe HeadPulse data in concussed subjects that may have experienced a concussion via an injury down to the age of 4.
- Trial name
- DISCOVERY (NCT07190963)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- MindRhythm, Inc.
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Postconcussion Syndrome, Mild Traumatic Brain Injury
Effectiveness of Rehabilitation in Adults Suffering From Persistent Concussion Symptoms
Protocol Summary The present study was developed to better understand the effects and benefits of individualizing rehabilitative treatments based on subgroup classifications determined by a standardized clinical examination.
- Trial name
- NCT06069700
- Testing
- Non-pharmacological Individualized rehabilitative therapy, Non-pharmacological Usual care therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto