Clinical trials: Concussion
Mild Traumatic Brain Injury
The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure
The administration of N-acetyl-cysteine (an anti-oxidant) for seven days along with observation will result in improved hearing and balance function in individuals who demonstrate these disorders after blast exposure when…
- Trial name
- NCT00822263
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Head Injury Trauma
Osteopathic Manipulative Treatment RCT and Computational Modeling for Head Injuries in Mixed Martial Artists
The purpose is to test how osteopathic medicine (OMM) improves recovery after a hit to the head during Mixed Martials Arts (MMA).
- Trial name
- NCT06851234
- Testing
- osteopathic manipulative medicine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Mild Traumatic Brain Injury
Evaluating Huddles as a Novel Approach to Improving Concussion Safety
Investigators will conduct a randomized controlled trial assessing the effectiveness and implementations of Pre-Game Safety Huddles (Huddles) in youth soccer.
- Trial name
- NCT06864611
- Testing
- Pre-Game Safety Huddles
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Mild Traumatic Brain Injury
Advanced Imaging Tools in the Study of Mild Traumatic Brain Injury
We will utilize a set of imaging modalities including computed tomography (CT), positron emission tomography (PET), and a suite of magnetic resonance imaging (MRI) tools, to investigate the changes in the human brain resulting…
- Trial name
- mTBI (NCT01044615)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kettering Health Network
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 1
This study will assess the effects of exercise and non-concussive bodily contact on eye-tracking scores collected by the EYE-SYNC eye-tracking device.
- Trial name
- ETA-TV (NCT02844543)
- Testing
- EYE-SYNC eye-tracking device, SCAT-3, Desktop Eye-Tracker
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Stanford University
Concussion
Vascular Assessment of Regulation Index Arrays Registry
The objective of this patient registry is to collect and analyze physiological data associated with baseline and brain injury identified in standard clinical practice (Normal Values, Recovery Curves, Correlation between Symptoms…
- Trial name
- VARIA (NCT02435082)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroChaos Solutions, Inc.
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Brain Concussion, Traumatic Brain Injury
Balance and Mild Traumatic Brain Injury (TBI)
The purpose of this pilot project is to determine whether using one inertial sensor on the waist during routine clinical balance testing (i.e.
- Trial name
- NCT01377454
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury
The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
The purpose of the proposed project is to determine if the VOMS is an effective screening tool to identify and track recovery of vestibular and ocular motor impairment and symptoms following mTBI, that corpsman-level medical…
- Trial name
- NCT02634944
- Testing
- Vestibular Ocular Motor Screening Tool (VOMS)
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Post-concussion Syndrome
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
The goal of this project is to determine if it is possible to assess Cerebrovascular Reactivity (CVR) to hypercapnia with functional Near Infrared Spectroscopy (fNIRS).
- Trial name
- NCT01789164
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Concussion, Eye
The Effects of Concussion on Gait and Posture in Individuals With Peripheral Vision Loss
Changes in gait and balance often occur in individuals who have suffered a concussion. In addition, a subset of concussed individuals also experience peripheral vision loss.
- Trial name
- NCT05948501
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gaylord Hospital, Inc
Mild Concussion, Healthy Volunteers
A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging
The goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography whole head device using optically pumped magnetometers using Helium 4 as the sensitive element (OPM He4) to…
- Trial name
- DEMAGUS (NCT06244472)
- Testing
- Experiment 1: visual and auditory attention task, Experiment 2: language production and rest tasks, Experiment 3: visuo-motor task
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Post-Concussion Syndrome, Mild Traumatic Brain Injury
Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury
Neck pain, dizziness and headache are common symptoms following mild traumatic brain injury (mTBI). The efficacy of cervical spine and vestibular-ocular system impairments intervention need to be determined.
- Conditions
- Post-Concussion Syndrome, Mild Traumatic Brain Injury, Vestibular Disorder, Whiplash Injuries
- Trial name
- NCT03677661
- Testing
- Conventional approach, Personalized rehabilitation program
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Concussion
Q-collar and Brain Injury Biomarkers
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02271451
- Testing
- Q collar
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Traumatic Brain Injury
Treatment Optimization of Brain-injured Warfighters
Prescribed sub-symptomatic adaptable exercise treatment (SAET) is a potential solution that promotes recovery needs following a TBI.
- Trial name
- (TOBI-SET) (NCT06561100)
- Testing
- Sub-symptomatic Adaptable Exercise Treatment (SAET), Stretching Control Group (SCG)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Concussion, Mild
Early Sub-threshold Exercise Treatment for Concussion
Each year millions of Americans suffer concussions as a result of accidents in sports, at work or through military service. Adolescents take the longest to recover from the effects of concussion yet no therapy exists to help…
- Trial name
- NCT03569709
- Testing
- Aerobic Exercise, Rest, Stretching
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Concussion
Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment
This study will synthesize a behavioral profile of impaired driving performance for teenage patients with mild traumatic brain injury (mTBI), or concussion, from one week post-concussion to six weeks post-concussion.
- Trial name
- NCT02278029
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati