Clinical trials: Conditioned Pain Modulation
Pain, Transcranial Direct Current Stimulation
Transcranial Versus Suboccipital Direct Current Stimulation
Randomized controlled trial, in parallel with cross-control design. Two groups of healthy subjects will be randomly selected to transcranial stimulation group or suboccipital stimulation group.
- Trial name
- NCT04117256
- Testing
- Direct Current Stimulation
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Fibromyalgia
Effectiveness of Electro Neuro Adaptive Regulator in Patients With Fibromyalgia
Background: There is evidence linking conditioned pain modulation (CPM) deficiency with musculoskeletal pain syndromes such as fibromyalgia, Evidence shows that different physical therapies could activation situations of chronic…
- Trial name
- SCENAR (NCT03882567)
- Testing
- Electro Neuro adaptative Regulator
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad Rey Juan Carlos
Knee Osteoarthritis, Chronic Pain
Neurophysiological Mechanisms Involved in Knee Osteoarthritis
Introduction: Total knee arthroplasty (TKA) is an effective intervention to relieve people with osteoarthritis (OA). Nevertheless, 15 to 30% of patients continue to experience severe pain following surgery.
- Trial name
- NCT03556423
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Université de Sherbrooke
Neck Pain Musculoskeletal, Chronic
Association Between Conditioned Pain Modulation and the 4-week Response to Spinal Mobilization in Adults With Chronic Neck Pain
The goal of this observational study is to learn if there is a relationship between conditioned pain modulation or CPM (a test of your brain's ability to inhibit pain) and longitudinal clinical outcomes following one spinal/joint…
- Trial name
- CPMNeck (NCT07194603)
- Testing
- Spinal mobilization (SM) of the neck
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Azusa Pacific University
Neck Pain
Conditioned Pain Modulation in Chronic Neck Pain Patients
The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.
- Trial name
- NCT03362203
- Testing
- Patients with chronic neck pain, Subjects without chronic neck pain
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Neck Pain
Effects of Painful Compared to Painless Manual Therapy on Pain Processing in University Students With Neck Pain
The purpose of this study is to evaluate the effects of provoking pain with manual therapy on pain processing in university students with recurrent or chronic neck pain.
- Trial name
- NCT05680688
- Testing
- Manual Therapy
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Josue Fernandez Carnero
Back Pain, Back Pain With Radiation
Changes in Radicular Pain and Pain Modulation
The objectives of this study are: 1)To investigate the difference in pain modulatory mechanisms using quantitative sensory testing (QST) between healthy controls and patients with radicular leg pain due to nerve root compression.
- Trial name
- NCT04193969
- Testing
- Pressure pain assessment using computer controlled cuff algometry, Temporal summation (TS), Conditioned pain modulation (CPM)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Spine Centre of Southern Denmark
Ischemic Preconditioning
Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Knee Osteoarthritis
Introduction: Musculoskeletal disorders have affected approximately 1.3 billion people worldwide. Evidence shows that chronic diseases and musculoskeletal conditions often occur together, and among them it is estimated that more…
- Trial name
- NCT05059652
- Testing
- Ischemic Preconditioning
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Paulista University
Migraine, Fibromyalgia
The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia
Migraine and Fibromyalgia (FM) are chronic pain disorders characterized by altered central pain processing and impaired endogenous pain inhibition.
- Conditions
- Migraine, Fibromyalgia, Conditioned Pain Modulation
- Trial name
- NCT07841509
- Testing
- Remote Electrical Neuromodulation (REN) device
- Where
- 2 sites in United States, Israel
- Volunteers
- 120 people
- Sponsor
- Theranica
Healthy
The Effects of a Moderate Intensity Training Program Versus a High Intensity Training Program on Central Pain Processing
Previous studies have shown that healthy individuals who take more steps per day and who spend more time on moderate- to vigorous-intensity activities exhibit better pain inhibition and less pain facilitation.
- Trial name
- ChronicPA-PAIN (NCT06207422)
- Testing
- Moderate intensity training program, High intensity training program
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Ghent
Healthy Adult
Impact of Aerobic Exercise on Pain Modulation in Healthy Adults
Exercise-Induced Hypoalgesia (EIH) refers to reduced pain sensitivity following exercise, particularly in response to noxious stimuli.
- Trial name
- NCT07083219
- Testing
- Aerobic High Intensity Interval Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Healthy Subjects
Influence of Propranolol on Conditioned Pain Modulation
An extensive amount of studies indicate that conditioned pain modulation (CPM) test paradigms can be of use to evaluate the efficacy of the endogenous pain inhibition pathway in healthy controls and pain patients.
- Trial name
- NCT02808611
- Testing
- propranolol
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Kristian Kjær Petersen
Low Back Pain
Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia.
- Trial name
- NCT06544525
- Testing
- Physical therapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Brooke Army Medical Center
Anesthesia, Pain
Memory & Conditioning Under Anesthesia
The purpose of this study is to determine the effects of pain on long-term memory and conditioned physiologic responses in the presence and absence of distinct intravenous anesthetics.
- Trial name
- MCA (NCT04062123)
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low-back Pain
Efficacy of Mobilization With Movement on Conditioned Pain Modulation in Chronic Low Back Pain Patients
Patients with chronic low back pain may have altered endogenous mechanisms, which can be evaluated with conditioned modulation paradigms.
- Trial name
- NCT06078033
- Testing
- Mobilization with movement
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Eleuterio Atanasio Sánchez Romero
Pain Control, Anxiety
Virtual Contexts for Affective Modulation
This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior.
- Conditions
- Pain Control, Anxiety, Memory
- Trial name
- VCAM (NCT06986122)
- Testing
- Pain Threat Manipulation, Pain Controllability Manipulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Chronic Pain, Acute Pain
Study to Test the Value of a Pain Modulation Test in Predicting Persistent Postoperative Pain After Breast Cancer Surgery
The purpose of this study is to test the hypothesis that a preoperative test of pain modulation predicts persistent pain 4 months after breast cancer surgery.
- Trial name
- PREDO (NCT01767168)
- Testing
- comprehensive preoperative testing for risk factors of persistent postoperative pain
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Healthy Participants
Cognitive Conditioned Pain Modulation
This "pain reduces pain" study looks at how the brain reduces pain when a person feels two painful sensations at the same time. There is considerable evidence that the brain can "turn down" pain using natural endogenous…
- Trial name
- CognitiveCPM (NCT07234123)
- Testing
- conditioned pain modulation, test stimulus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neck Pain
Spinal Pain and Autonomic Responses to Chiropractic Care
This randomized, single-blinded study will investigate the effects of Spinal Manipulative Therapy on Heart Rate Variability and Pain Sensitivity in a population of patients with recurrent and persistent neck pain.
- Trial name
- SPARC (NCT03576846)
- Testing
- Stretching and Spinal manipulative therapy, Stretching
- Where
- 2 sites in Sweden
- Volunteers
- 131 people
- Sponsor
- Karolinska Institutet