Clinical trials: Conditioning
Moyamoya Disease, Moyamoya Syndrome
Evaluating Antiplatelet and Physical Therapy for Slowing Progression in Mild Moyamoya Disease.
Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease characterized by progressive stenosis or occlusion at the terminal portion of the internal carotid artery, with formation of an abnormal vascular network at…
- Conditions
- Moyamoya Disease, Moyamoya Syndrome, Aspirin, Remote Ischemic Conditioning
- Trial name
- MOUNT-EASE (NCT07762547)
- Testing
- aspirin treatment, Remote Ischemic Conditioning
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Beijing Tiantan Hospital
Video Assisted Thoracic Surgery (VATS), Postoperative Complications
Clinical Effects of Intraoperative Heat and Moisture Exchange Systems During Thoracic Surgery: A Prospective Observational Cohort Study
General anesthesia with endotracheal intubation bypasses the physiological warming and humidification functions of the upper airway, allowing cold and dry gases to reach the lower respiratory tract.
- Conditions
- Video Assisted Thoracic Surgery (VATS), Postoperative Complications, Pulmonary Complications in Surgical Patients, Humidification
- Trial name
- NCT07729319
- Testing
- Active Heated Humidification, Heat and Moisture Exchanger
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University
People Who Do Regular Conditioning Work
Comparison of Sports Anxiety, Sports Injury Anxiety, and Knowledge Levels Regarding Factors Causing Sports Injury in Individuals Who Regularly Engage in Conditioning Work With and Without a History of Injury
Anxiety, or anxiety disorder, is a common occurrence today. Studies have proven that sports have a high potential for stress and anxiety.
- Trial name
- NCT07259096
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Physical Conditioning
Taxi STEP (Social Networks, Technology, and Exercise Through Pedometers)
This study is divided into four groups. Group 1 includes Health Fairs implemented at NYC taxi garage bases and airport taxi holding lots and pedometers.
- Trial name
- NCT03010163
- Testing
- Health Fair, Pedometer, Text Messaging
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Labor and Childbirth, Labor (Obstetrics)--Complications
Development of a Multidimensional Predictive Model of Dystocic Labor. Association of Physical Condition and Psychosocial Factors With the Birth Process and Breastfeeding Success.
The goal of this observational study is to learn how a pregnant woman's physical fitness and emotional well-being can help predict the type of birth she will have (such as a natural vaginal birth versus a cesarean section or a…
- Conditions
- Labor and Childbirth, Labor (Obstetrics)--Complications, Hand Strength, Physical Conditioning, Human
- Trial name
- MPM-PD (NCT07635771)
- Where
- Spain
- Volunteers
- 420 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Stroke, Acute, Neuroprotection
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (EVT).
- Conditions
- Stroke, Acute, Neuroprotection, Ischemic Conditioning
- Trial name
- NCT06545734
- Testing
- Direct Ischemic Post-conditioning, Endovascular therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Huanhu Hospital
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
SHR2554/AZA + Overlapped Modified BUCY for High-risk/Relapsed Leukemia/MDS
This study was designed as a prospective, multicenter, open-label, randomized controlled trial. Eligible participants were patients aged 15-65 years with high risk or relapsed/refractory acute myeloid leukemia (AML), acute…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, MDS, Transplantation, Stem Cell
- Trial name
- NCT07575412
- Testing
- SHR2554/AZA + Overlapped mBUCY, mBUCY conditioning Regimen Group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Athletic Performance, Plyometric Exercises
Elastic Band-Resisted Plyometric Training in Young Soccer Players
This randomized controlled trial investigated the effects of elastic band-resisted plyometric training (EBPT) on jump performance in young male soccer players.
- Conditions
- Athletic Performance, Plyometric Exercises, Physical Conditioning, Human
- Trial name
- NCT07367230
- Testing
- Elastic Band-Resisted Plyometric Training, Traditional Plyometric Training, Regular Soccer Training (No Intervention)
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Serkan özgür
Heart Failure, Advanced Heart Failure
REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices
Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs.
- Conditions
- Heart Failure, Advanced Heart Failure, Left Ventricular Assist Device, LVAD
- Trial name
- REACTION-VAD (NCT07611188)
- Testing
- Remote Physical Conditioning Program (Telerehabilitation), Usual care. No Remote Monitoring.
- Where
- 10 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Puerta de Hierro University Hospital
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
SHR2554/AZA + Overlapped TBF for High-risk/Relapsed Leukemia/MDS
This study was designed as a prospective, multicenter, open-label, randomized controlled trial. Eligible participants were patients aged 15-60 years with high-risk or relapsed/refractory acute myeloid leukemia (AML), acute…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, MDS, Transplantation, Stem Cell
- Trial name
- NCT07562568
- Testing
- SHR2554/AZA + Overlapped TBF, mBUCY conditioning regimen
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Study on the Efficacy and Safety of the TmBU Conditioning Regimen in High-risk or Relapsed/Refractory Acute Leukemia
This project is a prospective, single-center, randomized controlled clinical study. The subjects were high-risk or relapsed/refractory AML or ALL patients aged ≤ 65 years diagnosed by bone marrow cell morphology, immunology…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Transplantation, Stem Cell, Conditioning Therapy
- Trial name
- NCT06816134
- Testing
- TmBU conditioning Regimen, mBUCY conditioning regimen
- Where
- China
- Volunteers
- 48 people
- Sponsor
- The First Affiliated Hospital of Soochow University
PTSD, Exercise Intensity
Using Exercise to Enhance Fear Extinction Learning
The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD).
- Conditions
- PTSD, Exercise Intensity, Fear Extinction, Fear Conditioning
- Trial name
- NCT07548125
- Testing
- Exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Josh Cisler
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Venentoclax, Myeloid Malignancies
Fludarabine Plus Melphalan Versus Addition of Venetoclax to Fludarabine/Melphalan Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in AML/MDS Patients Aged > 50 Years: a Multicenter, Randomized, Phase 3 Trial
Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) serves as a curative treatment modality for the vast majority of patients with hematological malignancies.
- Conditions
- Venentoclax, Myeloid Malignancies, Conditioning, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- NCT07396480
- Testing
- Venetoclax in combination with fludarabine and melphalan, Fludarabine and Melphalan
- Where
- 18 sites in China
- Volunteers
- 186 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Allografted With Myeloablative Conditioning
Complement and Graft-versus-host Disease
Allogeneic haematopoietic stem cell transplantation (HSCT) often remains the only curative treatment for haematological malignancies.
- Trial name
- NCT01520623
- Testing
- Serum concentration /Serum inflammatory
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HSCT, Nijmegen Breakage Syndrome
Study of Treosulfan-Based Conditioning for HSCT in Nijmegen Breakage Syndrome
Nijmegen breakage syndrome is one of the DNA repair defect disorders. A characteristic feature of these syndromes is a predisposition to the development of malignant neoplasms.
- Conditions
- HSCT, Nijmegen Breakage Syndrome, Treosulfan Based Conditioning
- Trial name
- NCT07316595
- Testing
- Treosulfan (Treo)
- Volunteers
- 24 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Stroke Acute, Cytoprotection
Ischemic Postconditioning in Acute Stroke Patients Receiving Endovascular Thrombectomy
This clinical trial will evaluate whether on-site ischemic postconditioning (IPostC) improves outcomes in acute stroke patients receiving endovascular thrombectomy (EVT) and explore its mechanisms.
- Conditions
- Stroke Acute, Cytoprotection, Ischemic Conditioning
- Trial name
- NCT06967025
- Testing
- Ischemic Postconditioning, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Remote, Ischemic Conditioning
Remote Ischemic Conditioning in Patients Undergoing Primary Percutaneous Coronary Intervention
This study aimed to detect the effects of remote ischemic conditioning on infarct size, global contractility, morbidity, mortality, and renal function in patients undergoing primary percutaneous coronary intervention.
- Conditions
- Remote, Ischemic Conditioning, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07272408
- Testing
- Remote ischemic conditioning, Normal primary percutaneous coronary intervention
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Helwan University
Aplastic Anaemia, Transplantation Conditioning
Modified Transplantation Regimen and aGVHD Prophylaxis for Severe Aplastic Anemia in the Setting of Allogeneic HSCT.
The investigators retrospectively evaluted the safety and efficacy of the modified transplantation conditioning and aGVHD prophylaxis in severe aplastic anemia in 4 transplantation centers.
- Trial name
- aGVHD (NCT06837987)
- Testing
- Modified transplantation system
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Hematology department of the 920th hospital
Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy
Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence.
- Conditions
- Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy, Remote Ischemic Conditioning
- Trial name
- NCT05355883
- Testing
- Remote Ischemic Conditioning (RIC), Hand Arm Bimanual Intensive Therapy (HABIT), Bimanual Cup Stacking Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- East Carolina University