Clinical trials: Conduction Block
Bradycardia, Sinus Node Dysfunction
ImageReady(TM) MR Conditional Pacing System Clinical Study
The objective of the SAMURAI Clinical Study is to collect data to confirm the safety, performance and effectiveness of the ImageReady System for use in the Magnetic Resonance Imaging (MRI) environment when used in accordance with…
- Trial name
- SAMURAI (NCT01781078)
- Testing
- MRI, ImageReady System implant
- Where
- 41 sites in United States, Australia and 5 more
- Volunteers
- 363 people
- Sponsor
- Boston Scientific Corporation
Sick Sinus Syndrome, Hypertension
Effect of Paced HR on Central BP
Central (aortic) blood pressure predicts heart, brain and kidney complications more reliably than the usual peripherally measured blood pressure.
- Trial name
- NCT07078487
- Testing
- Pacemaker and defibrillator
- Where
- Estonia
- Volunteers
- 22 people
- Sponsor
- University of Tartu
Acute Pain
Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty.
There is Controversy about what is more critical volume or concentration to achieve an optimum analgesic treatment with quadratus lumborum block.
- Trial name
- NCT04259645
- Testing
- Drug: Bupivacaine 0.375% 20 mL, Drug: Bupivacaine 0.375% diluted to 0.1875%
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Anna Uskova
Bradycardia Sinus, AV Block
The CT-verified Data Collection Study to Investigate the Correlation Between the Leadless Pacemaker Tip Location and Echo, ECG
The goal of this observational study is to assess inter-/intra- ventricular synchrony and ECG characteristics in relation to Micra tip location.
- Conditions
- Bradycardia Sinus, AV Block, Atrial Fibrillation (AF)
- Trial name
- NCT06910059
- Testing
- Observational
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Anesthesia, Conduction
IV Dexamethasone for Prolongation of Peripheral Nerve Block
This is a volunteer study examining the effect of different doses of IV dexamethasone on prolongation of median nerve block in the forearm.
- Trial name
- NCT02864602
- Testing
- IV dexamethasone
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Aortic Stenosis, Transcatheter Aortic Valve Implantation
Reversibility of Cardiac Conduction Disturbances Following TAVI
The management of patients with conduction disturbances (CDs) after transcatheter aortic valve implantation (TAVI) is unclear, especially in those with de novo electrocardiographic CDs (ECG-CDs) such as left bundle branch block.
- Conditions
- Aortic Stenosis, Transcatheter Aortic Valve Implantation, Conduction Disturbances
- Trial name
- TAVI-REVERSE (NCT06481137)
- Testing
- Electrophysiological study (EP study), ePatch (extended Holter Monitoring)
- Where
- Spain
- Volunteers
- 209 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Long QT Syndrome, Hypoglycemia
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism
The human ether-a-go-go-related gene HERG (encoding Kv11.1 potassium channels) is expressed in different parts of the body including the heart, pancreas and intestines.
- Trial name
- NCT03868657
- Testing
- Moxifloxacin
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block
LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI
Patients with new-onset complete LBBB (QRS > 120 ms, persisting > 24 h after TAVI) and moderately reduced LVEF (35-50%) will be screened in participating centers.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block, Reduced Left Ventricular Ejection Fraction
- Trial name
- LBB(AP)TAVI (NCT07909239)
- Testing
- Left bundle branch area pacing with pacemaker, Implantation loop recorder
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrioventricular Block, Sick Sinus Syndrome
AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals
This is a randomized, prospective clinical trial to determine the effects of two different pacemaker atrioventricular delay (AV delay) settings on heart function in patients with dual chamber pacemakers implanted for symptomatic…
- Conditions
- Atrioventricular Block, Sick Sinus Syndrome, Symptomatic Bradycardia, Cardiac Arrhythmia
- Trial name
- AV Delay (NCT02154750)
- Testing
- Long, fixed AV delay, Short, optimized AV delay
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Bradycardia; Sick Sinus Syndrome, AV Block
Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity.
The purpose of this study is to provide evidence that the Refined Ventricular Pacing Algorithm leads to clinically relevant reduction (at least 50% reduction) of the incidence of ventricular pacing.
- Trial name
- NCT00156741
- Testing
- Vitatron C50 D Model C50A2 of Vitatron C60 DR model C60A2, Required pacemaker setting
- Where
- 30 sites in Austria, Czechia and 9 more
- Volunteers
- 150 people
- Sponsor
- Medtronic BRC
Atrioventricular Block, Second and Third Degree, Heart Failure
Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block
This study is a multicenter, prospective, randomized study to assess if cardiac dysfunction patients with LVEF <50% and the estimated ventricular pacing percentage >40% with LBBP have the non-inferior safety and efficacy than CRT…
- Conditions
- Atrioventricular Block, Second and Third Degree, Heart Failure, Left Bundle Branch Pacing
- Trial name
- NCT05553626
- Testing
- Left bundle branch pacing, Bi-ventricular pacing
- Where
- China
- Volunteers
- 160 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Complete Heart Block, Second Degree Atrioventricular Block Möbitz Type II
Left Septal or Deep Septal Pacing to Prevent Pacing-induced Cardiomyopathy
Multicenter randomized controlled trial which will include patients with left ventricular ejection fraction >50% requiring a first implant of a cardiac pacemaker with expected high pacing percentages.
- Trial name
- DEEP (NCT06474819)
- Testing
- Pacemaker implant
- Where
- 6 sites in Spain
- Volunteers
- 326 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Left Bundle Branch Block, Left Bundle Branch Area Pacing
UHF ECG in LBBB and Response to CRT Prediction
The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing…
- Conditions
- Left Bundle Branch Block, Left Bundle Branch Area Pacing, Biventricular Pacing, Intraventricular Conduction Delay
- Trial name
- UHF BLOCK (NCT07057544)
- Testing
- LBBAP CRT device implantation, BVP-CRT
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Anaesthesia Conduction
Awake Local Anesthesia Infiltration Compared to Regional Nerve Block for Hand Surgeries
The study trying to fined out the best anaesthesia technique for hand flexor procedures which provide efficient anaesthesia while providing adequate surgical field exposure \& less blood loss
- Trial name
- NCT05767944
- Testing
- local anaesthesia infiltration, brachial plexus block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Ventricular Flutter, Atrioventricular Block
Pacemaker Utilization and Ventricular Pacing in Patients Undergoing Trans-catheter Aortic Valve Replacement (TAVR)
The purpose of this study is to assess the incidence (at 90-days) of ventricular pacing in patients undergoing permanent pacemaker placement after TAVR.
- Conditions
- Ventricular Flutter, Atrioventricular Block, Intraventricular Conduction Delay, Bundle Branch Block
- Trial name
- PPM in TAVR (NCT02994667)
- Testing
- Permanent Pacemaker Placement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
TAVI(Transcatheter Aortic Valve Implantation), Conduction Disorder
Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI
Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Conduction Disorder, Aortic Stenosis, Permanent Pacemaker Implantation
- Trial name
- NCT07201363
- Testing
- Biomarkers of inflammation and fibrosis in pre-procedural serum blood samples, Transthoracic echocardiography with myocardial deformation analysis and staging according to the extent of cardiac damage related to AS
- Where
- Croatia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Symptomatic First-degree Heart Block
Physiologic Pacing for Symptomatic First-Degree Heart Block
The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).
- Trial name
- NCT06245304
- Testing
- Dual chamber Medtronic pacemaker implantation., DDD-50 pacing program, AAI-DDD 50 pacing program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ascension Health
Osteoarthritis, Knee
Perineural Steroids for Peripheral Nerve Blocks
This study will look at the efficacy of dexamethasone for prolongation of peripheral nerve blocks.
- Trial name
- NCT02462148
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Heart Failure, Left Bundle Branch Block
High Septal Pacing for Cardiac Resynchronization Therapy
The purpose of this acute study is to perform a preliminary investigation of high septal right ventricular pacing in the vicinity of the His bundle region as an alternate or adjunctive means for cardiac resynchronization in…
- Conditions
- Heart Failure, Left Bundle Branch Block, Heart Disease
- Trial name
- HISTORY (NCT01325480)
- Testing
- Cardiac Pacing
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation