Clinical trials: Congenital Microtia
Microtia, Congenital, Microtia
Rib Microtia and the Erector Spinae Plane (ESP) Block
The erector spinae plane block is a novel regional anesthetic technique that allows for analgesia of the thorax and abdomen with a peripheral nerve block.
- Conditions
- Microtia, Congenital, Microtia, Anesthesia, Local, Anesthesia
- Trial name
- NCT03729427
- Testing
- Erector Spinae Plane Block
- Where
- United States
- Sponsor
- Stanford University
Insulin Sensitivity, Glucose Metabolism Disorders
Bisphenol A and Muscle Insulin Sensitivity
This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.
- Conditions
- Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
- Trial name
- NCT03771066
- Testing
- bisphenol A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Microtia
The Effect of Prebiotics on Endurance Performance
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
- Trial name
- NCT04946578
- Testing
- Prebiotic
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Microtia, Microtia-Anotia
Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology
The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate.
- Conditions
- Microtia, Microtia-Anotia, Craniofacial Microsomia, Goldenhar Syndrome
- Trial name
- CAUSE (NCT04351893)
- Where
- 10 sites in United States, Colombia and 2 more
- Volunteers
- 935 people
- Sponsor
- Seattle Children's Hospital
Microtia, Microtia, Congenital
Study of Analgesic Efficacy of Nerve Blocks on Otoplastic Surgery
Background: Children with microtia complain of severe postoperative pain during early postoperative days after rib cartilage harvest for auricular reconstruction.
- Trial name
- NCT04192708
- Testing
- intercostal nerve block under direct vision, intercostal nerve block under ultrasound guidance, paravertebral block under ultrasound guidance
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Inflammatory Bowel Diseases, Clostridium Difficile Infections
Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients
The goal of this research is to compare alterations of gut microbiota and fecal metabolomics alterations between inflammatory bowel disease patients infected with or without Clostridioides difficile.
- Conditions
- Inflammatory Bowel Diseases, Clostridium Difficile Infections, Microtia
- Trial name
- NCT05714566
- Testing
- Clostridioides difficile toxin detection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Congenital Microtia
Deep Learning for Flap Perfusion Detection
The aim of this study is to develop a convolutional neural network-based image recognition model to identify flap perfusion abnormalities after first-stage auricular reconstruction in patients with congenital microtia.
- Trial name
- DL-FPA (NCT07846332)
- Testing
- AI-assisted remote monitoring of flap perfusion abnormalities after first-stage auricular reconstruction
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Jing Xu
Crohn Disease, Microtia
Clinical Study on the Distribution of Digestive Tract Microbiota Before and After Ileocecal Resection in Crohn's Disease
In this study, the microbiota sequencing was used to investigate the changes of microbiota in the terminal ileum and the middle part of ascending colon, the mesenteric adipose tissue of ileum and ascending mesocolon, and oral…
- Conditions
- Crohn Disease, Microtia, Ileocecal; Lesion
- Trial name
- NCT05615116
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Craniofacial Microsomia, Hemifacial Microsomia
Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
This study is a multi-center, longitudinal cohort study of 125 infants with craniofacial microsomia (CFM) and 100 infants without craniofacial anomalies.
- Conditions
- Craniofacial Microsomia, Hemifacial Microsomia, Oculo-Auriculo-Vertebral-Syndrome, Goldenhar Syndrome
- Trial name
- CLOCK (NCT02224677)
- Where
- 5 sites in United States
- Volunteers
- 417 people
- Sponsor
- Seattle Children's Hospital
Amino Acid Change, Food Science
The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule
This study aims to understand how the Milk Protein Concentrate/Fast Protein (MCP/FP) investigational product (IP) compares to a control the Micellar Casein Isolate/Slow Protein (MCI/SP) product in healthy volunteers.
- Conditions
- Amino Acid Change, Food Science, Nutrition, Digestion Rate
- Trial name
- NCT06394687
- Testing
- Milk Protein Concentrate, Micellar Casein Isolate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Microtia
Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia (Australia)
AUR-201 is indicated for the treatment of Grade II, III, or IV unilateral microtia in patients 8 to 29 years of age.
- Trial name
- AUR-201 (NCT06225336)
- Testing
- AUR-201
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Auregen Biotherapeutics, SA
Microtia, UTI
Effect of Antibiotics on Urinary Microbiome
Planning to study urine microbiota at baseline and after administration of bactrim antibiotics in healthy volunteers. Will intermittently collect voided urine specimens for 16 s DNA analysis over a period of 6 months after 2…
- Conditions
- Microtia, UTI, Bacteriuria, Antibiotic Resistant Infection
- Trial name
- NCT04230746
- Testing
- Bactrim DS 800Mg-160Mg Tablet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Microtia
Long-Term Follow-Up Study of Unilateral Microtia Patients Implanted With AUR-201
Long-term follow-up of unilateral microtia patients implanted with AUR-201.
- Trial name
- AUR-201 (NCT06078566)
- Testing
- AUR-201
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Auregen Biotherapeutics, SA
Overweight, Microtia
Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans
Previous work of the investigators demonstrated the anti-obesity and anti-steatosis potential of the Amazonian fruit camu-camu (CC) in a mouse model of diet-induced obesity [1].
- Conditions
- Overweight, Microtia, Endotoxemia, Metabolic Syndrome
- Trial name
- NCT04130321
- Testing
- Camu camu
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Ear Deformities, Acquired, Ear; Deformity, Congenital
Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures
This study evaluates the efficacy of the AuryzoN devices in the ear and nose reconstruction surgeries, both in terms of operative time and overall quality of reconstruction.
- Conditions
- Ear Deformities, Acquired, Ear; Deformity, Congenital, Microtia, Nose Deformity
- Trial name
- NCT03624608
- Testing
- AuryzoN Family of Devices
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Reconstrata, LLC
Congenital Microtia
Case Management for Microtia
The aim of this study is to develop an intelligent, full-course case management model for patients with microtia, enabling them to receive continuous, individualized nursing and health management services across the stages from…
- Trial name
- NCT07846345
- Testing
- Microtia case-management platform
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Jing Xu
Microtia
Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia
AUR-201 is indicated for the treatment of Grade II, III, or IV unilateral microtia in patients 8 to 29 years of age.
- Trial name
- AUR-201 (NCT06072040)
- Testing
- AUR-201
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Auregen Biotherapeutics, SA
Microtia
Tissue Engineering Microtia Auricular Reconstruction: in Vitro and in Vivo Studies
Platelet-rich plasma (PRP) has mixed growth factors such as TGF-ß1 and TGF-ß2, vascular epithelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor (IGF).
- Trial name
- NCT00958802
- Testing
- Platelet-rich plasma (PRP), Chondrocyte culture with FBS medium
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Taipei Medical University WanFang Hospital
Microtia, Outcome Assessment
Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery
Eligible patients will be admitted from the outpatient clinic to complete the relevant examinations after admission（Preoperative routine examination and chest CT）.
- Conditions
- Microtia, Outcome Assessment, RCT, Surgery Related Complications Rate
- Trial name
- NCT06763991
- Testing
- Two-stage connection, One-stage connection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sichuan Provincial People's Hospital
Neonatal Jaundice, Microtia
Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice
This is a randomized double-blind placebo-controlled parallel group superiority clinical trial among 94 pregnant women (47 in each group) to investigate the effect of maternal perinatal probiotic supplementation on neonatal…
- Conditions
- Neonatal Jaundice, Microtia, Pregnancy Related, Hyperbilirubinemia, Neonatal
- Trial name
- NCT06087874
- Testing
- Vivomixx®
- Where
- Hong Kong
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong