Clinical trials: Congestive Heart Failure, completed
Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure
Saxagliptin and Cardiac Structure and Function
Diabetes is associated with a substantially increased risk of heart failure, which is associated with substantial morbidity and mortality.
- Trial name
- SCARF (NCT02481479)
- Testing
- Saxagliptin
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Potential Applications for Heart Failure, Volume Overload
Zero Sodium Peritoneal Dialysate Protocol Pilot Study
The following pilot study will be undertaken to determine the effects of use of a zero-sodium peritoneal dialysate solution (10% dextrose in sterile water) on sodium removal as compared to a standard peritoneal dialysis solution.
- Trial name
- NCT03801226
- Testing
- Two-hour dwell with 10% dextrose in sterile water, Two-hour dwell with Dianeal Low-Calcium with 4.25% Dextrose
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Heart Failure With Mid Range Ejection Fraction
Outcome of Discharged HFmrEF Patients
This study aimed to define the independent risk factors related cardiac events (cardiac death or heart failure-related hospitalization) among heart failure with mildly reduced ejection fraction (HFmrEF) patients who discharged…
- Trial name
- OUDI-HF (NCT05240118)
- Volunteers
- 1,693 people
- Sponsor
- Xiangtan Central Hospital
Heart Failure, Arrhythmias, Cardiac
Japanese Assessment of Indication Based Programming
The purpose of this clinical investigation is to assess the programming behavior of the physicians in the patient cohort. Furthermore, the acceptance level of specific programming recommendations based on the patient's clinical…
- Trial name
- JASMINE (NCT01143220)
- Testing
- No specific interventions
- Where
- 45 sites in Japan
- Volunteers
- 235 people
- Sponsor
- Boston Scientific Corporation
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Acute Congestive Heart Failure Urgent Care Evaluation
This prospective validation study evaluates the ability of a risk algorithm, which can simultaneously predict the risk of death at 7 days and 30 days for patients with acute heart failure presenting to the emergency department.
- Trial name
- ACUTE (NCT02634762)
- Where
- Canada
- Volunteers
- 1,983 people
- Sponsor
- Institute for Clinical Evaluative Sciences
Heart Failure
A Pharmacokinetics, Safety and Tolerability Study of Multiple Formulations of BMS-986231 in Healthy Participants
Main Objective of this study is to compare the single intravenous (IV) infusion pharmacokinetics (PK) of BMS-986231 and its metabolites (BMT-284730, BMT-279554, and CAR-000463) following of up to 2 test formulations of BMS-986231…
- Trial name
- NCT03891108
- Testing
- BMS-986231 Formulation A, BMS-986231 Formulation B, BMS-986231 Formulation C
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Heart Failure
Mechanisms in Heart Failure With Normal EF
The guiding hypotheses are that (1) mechanisms in addition to diastolic dysfunction, while normal at rest, are compromised with stress, leading to symptoms of HF, and (2) that an increased proportion of the increase in LV…
- Trial name
- HFpEF (NCT00587808)
- Testing
- RHC with VO2 consumption
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Precapillary Pulmonary Hypertension
Adherence of Diuretics in Pulmonary Hypertension
In this prospective study, the investigators will implement a systematic assessment of adherence to diuretics in a cohort of patients with precapillary pulmonary hypertension.
- Trial name
- PHARE (NCT05167968)
- Testing
- No intervention (Observational cohort)
- Where
- France
- Volunteers
- 227 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Coronary Artery Disease
3/7 Resistance Training Method in Cardiac Rehabilitation
Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen…
- Trial name
- NCT05696990
- Testing
- 3/7 Resistance Training Method, 3X9 Resistance Training Method
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Université Libre de Bruxelles
Heart Failure, ICD
Comparing Rate Response With CLS Versus Accelerometer ICD Settings in Heart Failure Patients With BIOTRONIK CRT-Ds
Dr. Jonathan Hsu and Dr. Eric Adler are conducting a research study to find out more about how implantable cardiac defibrillator (ICD) settings can be adjusted to improve patient cardiovascular health and quality of life.
- Conditions
- Heart Failure, ICD, Chronotropic Incompetence
- Trial name
- CLASS (NCT02693262)
- Testing
- CLS Mode on Biotronik CRT-D, Accelerometer Mode on Biotronik CRT-D
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Heart Failure With Reduced Ejection Fraction
Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists
The primary objective of this study is to determine if a best practice alert (BPA) system that prompts providers to consider the addition of a mineralocorticoid receptor antagonist (MRA) in eligible patients with heart failure…
- Trial name
- PROMPT-MRA (NCT04903717)
- Testing
- Best Practice Alert
- Where
- United States
- Volunteers
- 1,210 people
- Sponsor
- Yale University
Mechanical Dyssynchrony, Heart Failure
Evaluating Effects of a Left Bundle Branch Block
A left bundle branch block (LBBB) is related to abnormal cardiac conduction and mechanical asynchrony and is associated with hypertension and coronary artery disease.
- Conditions
- Mechanical Dyssynchrony, Heart Failure, Bundle-Branch Block
- Trial name
- NCT00269659
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Heart Failure
Study to Improve the Treatment of Patients With Heart Failure by General Practitioners
The purpose of this study is to determine whether it is possible to improve the care of general practitioners for patients with heart failure.
- Trial name
- TOPHU (NCT01662323)
- Testing
- GP's treating HF according the dutch guidelines
- Volunteers
- 683 people
- Sponsor
- Julius Center
Heart Failure, Ischemic Cardiomyopathy
Optima Coronary Artery Disease (CAD) (Optimal Mechanical Evaluation)
To evaluate the impact of left ventricular (LV) lead location on LV mechanical function.
- Trial name
- NCT00896142
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Chronic Coronary Syndrome, Heart Failure
COVID-19 Related Lockdown Effects On Chronic Diseases
The containment associated with the VIDOC-19 pandemic creates an unprecedented societal situation of physical and social isolation.
- Conditions
- Chronic Coronary Syndrome, Heart Failure, AMD and Macular Edema, Chronic Respiratory Failure
- Trial name
- CLEO-CD (NCT04390126)
- Testing
- life questionnaires, questionnaire
- Where
- France
- Volunteers
- 1,343 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Heart Failure, Congestive
Meta-Iodobenzylguanidine Scintigraphy Imaging in Patients With Heart Failure and Control Subjects Without Cardiovascular Disease
The study is designed to study the utility of 123I-mIBG as a diagnostic imaging agent to predict cardiac outcomes in subjects with heart failure and in comparison to subjects without cardiovascular disease.
- Trial name
- NCT00126425
- Testing
- 123I-mIBG (meta-iodobenzylguanidine)
- Where
- United States
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Myocardial Infarction, Heart Failure
A Study of VentriGel in Post-MI Patients
This Phase I, open label, study will investigate the effects of VentriGel injection in patients who have experienced a first, large ST elevation myocardial infarction (STEMI) treated by PCI within the past 3 years and have…
- Conditions
- Myocardial Infarction, Heart Failure, Left Ventricular Remodeling
- Trial name
- NCT02305602
- Testing
- VentriGel
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Ventrix, Inc.
Heart Failure
Intervention With Vitamin D and Omega-3 Supplements and Incident Heart Failure
This study will examine whether an intervention with vitamin D or fish oil supplements can reduce the risk of heart failure among adult men and women during a follow up period of up to five years (starting from the time of…
- Trial name
- NCT02271230
- Testing
- Vitamin D and fish oil, Fish oil (EPA/DHA) alone, Vitamin D alone
- Where
- United States
- Volunteers
- 25,871 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Targeted Intervention to Improve Medication Adherence in Cognitively Impaired Patients With HF (TARGET)
Trialing an automated medication dispensing device (AMDD) to improve medication adherence in patients with heart failure.
- Trial name
- TARGET (NCT01602731)
- Testing
- Automated Medication Dispensing Device
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
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