Clinical trials: Congestive Heart Failure
Cardiomyopathy
Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy-Induced Cardiomyopathy
The purpose of this trial or study is to determine if cardiac resynchronization therapy (CRT) can be a benefit to people who have impaired heart function due to past treatment with chemotherapy and/or chest radiation.
- Trial name
- MADIT-CHIC (NCT02164721)
- Testing
- Three-lead CRT-D (Defibrillator)
- Where
- 9 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Congestive Heart Failure
Monitoring in Congestive Heart Failure Study
This is a multi-center, non-randomized study designed to develop an external monitor for CHF patients.
- Trial name
- MUSIC (NCT00557804)
- Testing
- MUSE clinical system
- Volunteers
- 362 people
- Sponsor
- Corventis, Inc.
Tricuspid Regurgitation, Tricuspid Valve Insufficiency
Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.
The hypothesis is that renal function will improve following tricuspid valve intervention. A reduction in renal biomarkers is also expected.
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Cardio-Renal Syndrome, Frailty
- Trial name
- TriRenGe (NCT07464106)
- Testing
- Transcatheter edge-to-edge repair (TEER)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Robert Bosch Medical Center
Heart Failure
Prospective Minnesota Study of ECHO Tissue Doppler Imaging in Cardiac Resynchronization Therapy
The purpose of this study is to assess whether tissue doppler imaging is useful in predicting which patients will respond most to Cardiac Resynchronization therapy ( a type of pacemaker)
- Trial name
- NCT00158015
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Hennepin Healthcare Research Institute
Skeletal Muscle Changes After Crt
Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response
Heart failure patients with left bundle branch block have a poor prognosis. Biventricular pacing which synchronize the heart pump action is associated with improved functional capacity.
- Trial name
- NCT01019915
- Testing
- CRT
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Helse Stavanger HF
Heart Failure, Dyspnea
Correlation Research Study: IQ2, NcIQ and IQ101
The new NcIQ thoracic impedance monitor is based on the predicate device, the IQ101. The new model uses the same 3-dimensional signal averaging as the original device, but also include second radio frequency signal to permit the…
- Conditions
- Heart Failure, Dyspnea, Hypertension, Pacemaker
- Trial name
- NMT-CT (NCT00491777)
- Testing
- Noninvasive Hemodynamic Patient Monitor
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Noninvasive Medical Technologies, Inc.
Heart Failure
Brain Volume and Cardiac Function in Heart Failure
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population.
- Trial name
- NCT06623344
- Testing
- Magnetic Resonance Imaging with or without Contrast
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Heart Failure
Bioimpedance-Guided Diuretics and Cardiac Progression in Asymptomatic Heart Failure
It has not been clearly elucidated whether volume control with diuretics is essential at an early stage in patients with heart failure (HF).
- Trial name
- NCT07801144
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kayseri Training and Research Hospital
Heart Failure With Reduced Ejection Fraction
Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification
A number of large randomized studies have demonstrated the importance of left ventricle ejection fraction (LV EF) for ventrucular tachyarhrythmia's (VT) prediction.
- Trial name
- PERFECT (NCT05539898)
- Testing
- ICD implantation
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- Astrakhan Federal Centre For Cardiac Surgery
Heart Failure, HFpEF
Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF)
The goal of this study is to learn whether stopping beta-blockers can help older adults with heart failure with preserved ejection fraction (HFpEF) feel better and function better.
- Conditions
- Heart Failure, HFpEF, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- DEPRESCRIBE (NCT07298993)
- Testing
- Beta-blockers
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure
Home Telemonitoring System for Patients With Heart Failure
This randomized controlled trial compares a home telemonitoring system (HTS) versus usual care during a 90 days follow-up of Heart Failure (HF) ambulatory patients, in order to evaluate if the use of the HTS improves self-care…
- Trial name
- NCT04071093
- Testing
- Home Telemonitoring System (HTS)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de Tucuman
Chronic Heart Failure
Multimodal Approach of Undernutrition in Chronic Heart Failure
The treatment of chronic heart failure (CHF) is a key challenge in public health. Despite medical advances, 1-year mortality of NYHA III-IV CHF is 28%. Undernutrition is an independent risk factor for mortality and complications.
- Trial name
- NUTRICARD (NCT01864733)
- Testing
- Physical rehabilitation (exercise).
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Failure
The Effect of Action Control Based Intervention on Adherence After Cardiac Rehabilitaiton
This will be a pilot study of the effect of an Action Control-based intervention (ACBI) on adherence to prescribed diet and exercise programs after cardaic rehabilitation. The purposes of this study are to: 1.
- Trial name
- NCT00602485
- Testing
- Action Control Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Summa Health System
Dilated Cardiomyopathy
Pregnancy and Dilated Cardiomyopathy
Increasing cases of women with dilated cardiomyopathy with a project of pregnancy are observed. However there is few knowledge and publications about cardiac diseases in pregnant women.
- Trial name
- NCT03235063
- Testing
- routinely care- no intervention
- Where
- 15 sites in France
- Volunteers
- 42 people
- Sponsor
- Nantes University Hospital
Heart Failure
The Role of CVP and EF in Patients With Cardio-renal Syndromes
The aim of the study is to explore association between increased central venous pressure, Ejection Fraction and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2.
- Trial name
- RoCVPinCRSs (NCT02792387)
- Testing
- CVP measurement
- Volunteers
- 11 people
- Sponsor
- Tbilisi State University
Heart Failure
Home-based Outpatient Multicenter Evaluation Using Electrocardiogram (HOME-ECG)
This prospective multicenter observational study will validate the accuracy of a previously developed artificial intelligence-enabled single-lead electrocardiogram (AI-ECG) model for identifying low ejection fraction and other…
- Trial name
- HOME-ECG (NCT07488052)
- Testing
- Single-Lead ECG Acquisition [Apple Watch and QOCA ECG102D]
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Physical Activity
Training Intervention in Heart Failure and Frail Elderly Population
There is enough scientific evidence of the benefits detection of frailty in patients with heart failure, which is an important prognostic factor.
- Trial name
- TIHFEP (NCT02365155)
- Testing
- Multicomponent training intervention., Nutrition intervention, Cognitive intervention
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital de la Ribera
Chronic Heart Failure With Reduced Ejection Fraction
A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had…
- Trial name
- VICTOR (NCT05093933)
- Testing
- Vericiguat
- Where
- 519 sites in United States, Argentina and 34 more
- Volunteers
- 6,106 people
- Sponsor
- Merck Sharp & Dohme LLC
Heart Failure
Strain X Cardiopulmonary Test
Introduction : Patients with heart failure (HF ) with systolic dysfunction of moderate to severe exhibit significant reduction in the ability to exercise compared to those with mild dysfunction , and have worse prognosis.
- Trial name
- NCT02869178
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Daniella Cunha Brandao
Cardiomyopathy With Unknown Etiology
Risk Stratification of Heart Failure in Cardiomyopathies.
The investigators aimed to use CMR technique in helping diagnose the etiology of unknown cardiomyopathy. Try to make a risk stratification of susceptible heart failure based on the extent of myocardial impairment.
- Trial name
- EARLY-MYO-HF (NCT02941315)
- Testing
- etiologic treatment,anti-myocardial remodeling, anti-myocardial remodeling, anti-myocardial remodeling,anti-acute heart failure
- Where
- China
- Volunteers
- 150 people
- Sponsor
- RenJi Hospital