Clinical trials: Contractions
Cervical Assessment, Focal Myometrial Contractions
Focal Myometrial Contractions: Impact on Cervical Assessment and Association With Voiding
Focal myometrial (uterine) contractions occur in a substantial number of vaginal ultrasound examinations and can impede accurate cervical length measurement and placental location determination.
- Trial name
- NCT01513395
- Testing
- Interval bladder emptying
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chest Pain Atypical Syndrome
Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Non-cardiac chest pain (NCCP) is a common disorder whose pathophysiology is poorly understood. Some evidence suggests it may be related to sustained esophageal contractions (SECs) of longitudinal smooth muscle.
- Trial name
- NCT01839058
- Testing
- Esophageal Manometry
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Queen's University
Healthy Subjects, Elective Surgical Procedure
"Electromagnetical Stimulation of Phrenic Nerve to Generate Contraction of the Diaphragm"
The scientific study is intended to show that external non-invasive electromagnetic stimulation can be used to safely and effectively stimulate the phrenic nerve in awake healthy subjects as well as in ventilated, anesthetized…
- Trial name
- NCT04884698
- Testing
- Stimit Activator
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stimit AG
Labor
Labor Progress Indices and the Dynamics of the Individual Contraction During the Active Stage of Labor
Objective of the study: to obtain new data on the dynamics of the labor process, cervix dilatation and head station on the labor process and to develop a new progress indices.
- Trial name
- NCT01009411
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Postpartum Hemorrhage
The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Oxytocin causes myometrial contraction via the oxytocin receptor (OTR). Desensitization of the OTR after exposure to oxytocin has been demonstrated in previous studies.
- Trial name
- NCT03408054
- Testing
- Oxytocin, Nitroglycerin
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Muscle Fatigue, Muscle Strength
Short Term Omega-3 Supplementation on Performance
Nerves are the rate limiting factor that control muscle function. However, it is unknown if a nutritional supplement can change the nerve-muscle interaction, and therefore alter human performance.
- Trial name
- NCT02014233
- Testing
- Omega-3, Olive oil
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypertrophy, Contraction
Resistance Training Effects on Muscle Morphological, Mechanical and Contractile Properties
The aim of the research project is to investigate the influence of resistance-training prescription (repetition duration, time under tension and training volume) and sex have on morpho-functional adaptations of upper and…
- Trial name
- NCT04845295
- Testing
- resistance training
- Where
- Serbia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Type 2 Diabetes Mellitus
Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus
Diabetes is a chronic-degenerative metabolic disorder that has reached pandemic proportions mainly because of the increasing incidence and prevalence of type 2 diabetes mellitus (T2D).
- Trial name
- T2D_MTU (NCT05585502)
- Testing
- Training (minute oscillation stretching)
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Premature Atrial Complex, Premature Ventricular Contraction
The Heart Rhythm Twins Study
Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) are observed in the majority of individuals monitored for more than a few hours.
- Trial name
- NCT05866731
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Preterm Delivery, Preterm Contractions
The Impact of Bryophyllum on Preterm Delivery
The purpose of this study is whether Bryophyllum is more effective and has less side effects than traditional labor inhibitors in preventing preterm delivery.
- Conditions
- Preterm Delivery, Preterm Contractions, Cervical Shortening
- Trial name
- NCT00163579
- Testing
- Bryophyllum
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Neuromuscular Function, Muscle Activation
Mechanistic Drivers of Acute PAPE Responsiveness: Muscle Architecture, Contractile Kinetics, and Excitability in a Randomized Controlled Trial
The goal of this study is to find out if one short set of heavy half-squats can help football players jump higher right away-and to understand what happens inside their muscles and nerves to make that boost happen.
- Conditions
- Neuromuscular Function, Muscle Activation, Postactivation Potentiation, Ultrasonography
- Trial name
- NCT06982937
- Testing
- High-Intensity Half-Squat, Treadmill running
- Where
- Poland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Electromyography
Age-related Differences in Shoulder Dynamic and Isometric Contractions
A cross-sectional descriptive study, in which the surface electromyographic activity of five shoulder muscles was compared in two populations: older adults and adults.
- Trial name
- NCT04706169
- Testing
- Surface Electromyography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Neurocognitive Dysfunction
Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli
This study is a prospective, multicenter, randomized (1:1) controlled comparative effectiveness trial of a transseptal approach to left ventricular ablation compared to a retrograde aortic approach to prevent cerebral emboli and…
- Trial name
- TRAVERSE (NCT03946072)
- Testing
- Transseptal Aortic Approach Catheter Ablation Procedure, Retrograde Aortic Approach Catheter Ablation Procedure
- Where
- 21 sites in United States, Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle tone after delivery.
- Trial name
- NCT02051231
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Preterm Labor, PreTerm Birth
Electrical Inhibition of Human Preterm Contractions
The purpose of this study is to explore a new method to stop preterm uterine contractions using an electrical device. The device, an "electrical pacemaker for the uterus," has been approved by the Food and Drug Administration…
- Conditions
- Preterm Labor, PreTerm Birth, Preterm Labor With Delivery Nos
- Trial name
- NCT02983240
- Testing
- Electrical Uterine Pacemaker
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- e-Bio Corp
Athletic Performance, Volleyball
Acute Effects of Bilateral Versus Unilateral Isometric Conditioning Activity on Jump Performance in Volleyball Players
This randomized crossover trial investigates the acute effects of bilateral and unilateral isometric conditioning activity on bilateral and unilateral jump performance in highly trained male volleyball players.
- Conditions
- Athletic Performance, Volleyball, Isometric Strength Training, Post Activation Potentiation
- Trial name
- BI-UNI ICA (NCT07709104)
- Testing
- Bilateral Isometric Conditioning Activity, Unilateral Isometric Conditioning Activity, Low-Intensity Treadmill Walking
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Postpartum Hemorrhage
In Vitro Myometrial Contractions in Laboring and Non-laboring Women
The purpose of this study is to compare the ability of an isolated sample of uterine muscle tissue (in a tissue bath) to contract in the presence of various drugs.
- Trial name
- NCT01689311
- Testing
- Oxytocin, Ergonovine, Prostaglandin F2alpha
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnant Women
Testing Effects of Melatonin on Uterine Contractions in Women
The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women.
- Trial name
- MelPreg (NCT05358834)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postpartum Hemorrhage
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with…
- Trial name
- NCT06285396
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Subacromial Impingement Syndrome, Central Nervous System Sensitization
Muscle Function, Central Nervous System Sensitization, and Pain Profiling in Patients With Subacromial Pain (SAP-CNSS).
In this case-control study, the investigators compare shoulder muscle function, pain, and central nervous system sensitization in patients with Subacromial Pain (SAP) to that in healthy controls.
- Trial name
- NCT03326466
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital