Clinical trials: Contrast Agent
Magnetic Resonance Imaging
Phase I , MTD, Pharmacokinetic, Safety/Tolerability, Efficacy of IOP Injection for MRI in Healthy Subjects
Study Objectives Primary: To determine MTD and dose limiting toxicities (DLTs) of IOP magnetic resonance imaging (MRI) contrast agent in healthy subjects. Secondary: 1.
- Trial name
- NCT02744248
- Testing
- IOP Injection, 0.9% normal saline
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- MegaPro Biomedical Co. Ltd.
Contrast-enhanced MRI With Dotarem
Post-marketing Surveillance Study for Evaluation of Dotarem Safety
Guerbet conducted a non-interventional post-marketing surveillance study on its Magnetic Resonance Imaging (MRI) contrast agent Dotarem (gadoteric acid/gadoterate meglumine).
- Trial name
- NCT03048006
- Testing
- MRI with Dotarem
- Volunteers
- 44,456 people, healthy volunteers welcome
- Sponsor
- Guerbet
Calculi, Stenosis of Bile Duct
EUS Prior to ERCP in the Positive Setting of Positive Intraoperative Cholangiogram (IOC) During Cholecystectomy
Performing an EUS prior to ERCP in the setting of a positive intraoperative cholangiogram will identify and risk stratify patients for the presence of CBD stones and strictures.
- Trial name
- NCT01525355
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy
Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI)
Aortic coarctation is a relatively common cardiovascular condition with high associated mortality if not treated. Even with successful repair, however, close follow up is needed as late complications can result in significant…
- Trial name
- NCT00722904
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Magnetic Resonance Imaging Contrast Media Adverse Reaction, Sedation Complication
Non-operating Room Anesthesia Experiences in Pediatric Magnetic Resonance Imaging Cases
In recent years, out patient anesthesia applications have been increasing for diagnostic and interventional procedures for pediatric patients.
- Trial name
- NCT05423821
- Testing
- Anesthesia efficacy in patients undergoing MRI
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yunus Emre
Healthy Volunteers, Patients
Magnetic Resonance Imaging (MRI) Ofl Volunteers
Magnetic resonance is an imaging technique that uses magnetic fields and radio waves to create images of the body. The technology used in magnetic resonance imaging continues to improve.
- Trial name
- NCT00001711
- Testing
- MRI
- Where
- United States
- Volunteers
- 1,229 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Magnetic Resonance Imaging
Phase Ib, Administration the IOP Injection for MRI Contrast Agent in Healthy Subjects
The objective of the study is to assess the dose dependent changes in MRI signal intensity (SI) in liver after IOP Injection intravenous administration in healthy volunteers.
- Trial name
- NCT03399214
- Testing
- IOP Injection
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- MegaPro Biomedical Co. Ltd.
Myopia
A Prospective Evaluation of Contrast Sensitivity and Disability Glare in Refractive Surgery, a Sub-Study of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
The purpose of this study is to conduct a prospective assessment of small target contrast sensitivity and disability glare in refractive surgery.
- Trial name
- NCT00413868
- Testing
- LASIK, PRK, Small target contrast sensitivity and disability glare
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Breast Cancer Prevention, Breast Cancer Diagnosis
Supine Photon-Counting CT and Contrast-Enhanced Mammography Versus Breast MRI for Pretreatment Tumor Size in Breast Cancer Candidates for Neoadjuvant Chemotherapy
Retrospective single-centre agreement study in women with biopsy-proven invasive breast cancer who underwent CEM, supine PC-CT and prone breast MRI before neoadjuvant chemotherapy. Prone MRI is the clinical reference.
- Trial name
- PC CEM MRI (NCT06843083)
- Testing
- Supine photon-counting CT (PC-CT), CEM, Prone dynamic contrast-enhanced breast MRI
- Where
- Italy
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Graziella di Grezia
Renal Artery Stenosis, Kidney Diseases
Renal Artery Contrast-Free Trial
This study will compare the results of a clinically ordered abdominal CT angiography to a research non-contrast MR angiogram (MRA).
- Conditions
- Renal Artery Stenosis, Kidney Diseases, Hypertension
- Trial name
- REACT (NCT01576835)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Central Coast Cardiovascular Research
Contrast Enhancement in Magnetic Resonance Imaging, Healthy Volunteers
A Study to Learn More About the Safety and the Level of BAY 1747846 in Body Given as Injection Into the Vein at Increasing Single Doses in Japanese Healthy Male Participants
The goal of this clinical study was to learn more about BAY1747846 compared to placebo when given as an injection into the vein in Japanese healthy male participants: the safety of BAY1747846 when given at increasing single doses…
- Trial name
- NCT06125366
- Testing
- BAY1747846
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayer
Nephropathy
Efficacy of Statins In Prevention of CIN
To determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.
- Trial name
- SCIN (NCT01071993)
- Testing
- atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
CSF Circulation Disorder, Foramen; Monro, Obstruction
Cerebrospinal Fluid Movements Through Interventricular Foramina in Phase Contrast Magnetic Resonance Imaging (PC-MRI)
Assess the reproductibility of PC-MRI for cerebrospinal fluid movements through the interventricular foramina on volunteer subjects.
- Conditions
- CSF Circulation Disorder, Foramen; Monro, Obstruction, Mri
- Trial name
- MLCSFIV (NCT04145414)
- Testing
- MRI
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer
Screening Contrast-Enhanced Mammography as an Alternative to MRI
There are women for whom a screening breast MRI is clinically recommended, but not feasible either due to patient factors (body habitus, pacemaker or other implant, claustrophobia) or access (cost, other constraints).
- Trial name
- SCEMAM (NCT04764292)
- Testing
- Contrast-enhanced mammography, Iodinated Contrast Media (ICM)
- Where
- 3 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Wendie Berg
Venous Insufficiency of Leg, Venous Leg Ulcer
Non Contrast MRI in Lower Extremity
We collected retrospectively the non contrast MRI in chia yi memorial hospital for different venous disease of lower extremity morphology and flow ananlysis were done.
- Conditions
- Venous Insufficiency of Leg, Venous Leg Ulcer, Venous Occlusion, Contrast Media Reaction
- Trial name
- NCT04995432
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Circulatory; Change
Evaluating A Non-Invasive Tissue Perfusion Monitor
The Pedra perfusion system will be used to assess changes in perfusion in response to physiological stimuli. It will be compared to other standard diagnostics.
- Trial name
- NCT04630704
- Testing
- Pedra
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pedra Technology, PTE LTD
Inner Ear ; Meniere's Disease; Imaging
Acceleration of the Kinetics of Diffusion of Gadolinium in the Perilymphatic Structures of the Inner Ear.
To determine the optimal delay after Gadolinium injection to analysis inner ear structures as measured by repeated MR 3D-FLAIR Weighted Imaging.
- Trial name
- FAST-HYDROPS (NCT04949321)
- Testing
- Magnetic Resonance Imaging with Single dose of gadobutrol (Gd-DO3A-butrol, Gadovist® 0.1 mmol/kg, 1 mmol/mL)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Coronary Artery Disease, Diabetes Mellitus Type 2
Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 (GLP-1) on myocardial perfusion in type 2 diabetes (DM).
- Trial name
- GLP-1 (NCT01021865)
- Testing
- Glucagon-Like-Peptide-1/Regadenoson/Perflutren Lipid Microsphere
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nephropathy
A Randomized Trial of Rosuvastatin in Elective Angioplasty to Prevent Contrast-induced Nephropathy (CLEAR-CIN).
The investigators analyzed the HMG-CoA reductase inhibitor, rosuvastatin, for the prevention of contrast-medium-induced nephropathy in patients undergoing primary angioplasty.
- Trial name
- CLEAR-CIN (NCT02737319)
- Testing
- Rosuvastatin
- Where
- Brazil
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Artery Disease, Coronary Atheroscleroses
Screening Coronary Artery Disease Using artiFicial intelligencE in Non-contrast Computed Tomography
This project aims to improve direct patient care by reducing the risks of futile exposure to ionizing radiation and iodinated contrast in patients referred for coronary computed tomography angiography
- Trial name
- SAFE-CT (NCT06438393)
- Testing
- CT coronary angiography and non-contrast CT
- Where
- Portugal
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto