Clinical trials: Contrast Agent
Obesity
Microvascular Flow Assessment Repeatability Study: The MARS Study
The purpose of this study is to test a method of imaging (taking a picture) of the abdomen (belly), neck, thigh and calf (lower leg) areas of the body, using ultrasound along with a drug which makes the pictures look clearer.
- Trial name
- MARS (NCT01242020)
- Testing
- Perflutren Lipid Microsphere Injectable Suspension
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prostate Cancer (Diagnosis)
Prostate Cancer Secondary Screening in Sapienza and Policlinico Umberto I
Prostate Cancer (PCa) screening is still a controversial topic in the urology community, this is mostly linked to the low specificity of Prostate Specific Antigen (PSA) value.
- Trial name
- ProSa-I (NCT04803188)
- Testing
- Magnetic Resonance
- Where
- Italy
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Microvascular Function
Methodological Issues and Laser Speckle Contrast Imaging
Microcirculation, especially skin microcirculation, is a window towards systemic vascular function in magnitude and underlying mechanisms. Different techniques have been developed to assess the microcirculation.
- Trial name
- METHODO-LSCI (NCT01664572)
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Biliary Tract Cancer (BTC)
Prospective AI-Assisted Screening of Biliary Tract Cancer Using Non-Contrast CT
Biliary tract cancer is a group of malignant tumors involving the intrahepatic bile ducts, extrahepatic bile ducts, and gallbladder.
- Trial name
- BTC-NCCT-AI (NCT07911397)
- Testing
- AI-Assisted Biliary Tract Cancer Screening Using NCCT
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Heart Diseases
An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers
Definity (perflutren lipid microspheres, Lantheus Medical Imaging) is an ultrasound contrast indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of…
- Trial name
- NCT03882359
- Testing
- Echocardiogram, MVT-100, Definity
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Microvascular Therapeutics, LLC
Microcirculation
Comparison of Laser Speckle Contrast Imaging and Laser Doppler Imaging
The microcirculation plays a fundamental role in metabolic reactions and has been shown as an essential determinant in many clinical scenarios such as shock states, chronic and cardio-metabolic diseases.
- Trial name
- LACOM (NCT04660162)
- Testing
- Iontophoresis, Stepwise occlusion
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maasstad Hospital
Steatotic Liver Disease, Liver Fibrosis Progression in Chronic Liver Disease
Interventional AI-Human Collaboration for Steatotic Liver Disease Screening
Steatotic liver disease (SLD) is one of the most prevalent chronic liver diseases worldwide, affecting nearly 30% of the global population and projected to exceed 55% by 2040.
- Conditions
- Steatotic Liver Disease, Liver Fibrosis Progression in Chronic Liver Disease, Liver Steatosis, Liver Fibrosis
- Trial name
- NCT07613827
- Testing
- AI-human collaboration for SLD screening
- Where
- China
- Volunteers
- 7,969 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Mammographic Breast Density, Mammography
Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
The purpose of this study is to evaluate how well women may adopt a Contrast-enhanced Spectral Mammography (CESM) as their yearly breast screening test compared to the standard 2-D or 3-D mammogram.
- Trial name
- S-CESM (NCT04904757)
- Testing
- Contrast-enhanced spectral mammography (CESM)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Dry Eye Disease
The Visual Effect of an Investigational Artificial Tear in the Tear Layer.
The purpose of this study is to investigate how the addition of a new artificial tear product when applied to the tear layer affects contrast sensitivity and optical aberrations over time.
- Trial name
- NCT00395759
- Testing
- Optiva artificial tear by Allergan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease
ISOVUE Comparative Trial
This study aimed to investigate a novel technique for intraoperative quantitative and qualitative feedback during discectomy and endplate preparation in TLIF.
- Conditions
- Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
- Trial name
- ISOVUE (NCT07363759)
- Testing
- ISOVUE 300 Observation, ISOVUE 300 Feedback
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Kidney Diseases, Chronic Kidney Disease 5D
The Discrepancy in Radiologists' Practice of Intravenous Contrast Imaging Studies Among Chronic Kidney Disease Patients
There is a discrepancy between protocols used for intravenous imaging for chronic kidney disease including hemodialysis patients among different hospitals and even, among radiologists same selves.
- Trial name
- NCT05729126
- Testing
- Questionnare
- Where
- Egypt
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Benha University
Brain Diseases
Multi-center Study of Artificial Intelligence Model for Gadolinium-based Contrast Agent Reduction in Brain MRI (MAGNET)
MAGNET is a multi-center and prospective study to minimize Gadolinium-based Contrast Agent (GBCA) combining novel artificial intelligence (AI) methods with pre-contrast images and/or low-dose images to synthesize virtual…
- Trial name
- MAGNET (NCT05754476)
- Testing
- Low-dose GBCA levels
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Healthy
Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT
Patients who are scheduled by their health care provider for routine computed tomography (CT) scan will be asked to participate in this study.
- Trial name
- NCT00478556
- Testing
- Omnipaque, Gastroview
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Rheologic Disease, Sickle Cell Disease
Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Disease
The purpose of this study is to examine how abnormal blood flow in the small vessels (microvessels) of the heart, muscle and kidney in paroxysmal nocturnal hemoglobinuria (PNH) or sickle cell disease leads to poor functioning of…
- Conditions
- Rheologic Disease, Sickle Cell Disease, Paroxysmal Nocturnal Hemoglobinuria
- Trial name
- NCT01294891
- Testing
- Imaging
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Renal Disease
A Study on the Verification of Kidney CT Non-inferiority Using Low Concentration Contrast Agent
This prospective study aims to evaluate clinical usefulness of low-voltage renal CT using low-concentration contrast agent and to compare with existing imaging techniques.
- Trial name
- NCT05831943
- Testing
- Contrast enhanced Kidney CT
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Breast Cancer
Quantitative Methods for Supplementing Contrast-Enhanced Magnetic Resonance Imaging of Breast Cancer
Contrast-enhanced magnetic resonance imaging (CE-MRI) is now established as the most accurate non-invasive imaging modality for characterizing breast cancer.
- Trial name
- NCT02058758
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Coronary Artery Disease
Acquiring Consensus for Contrast Echocardiography System Settings - ACCESS Study
This study evaluated and optimized settings for, and evaluated the performance of, AI-700-enhanced echocardiographic imaging on several ultrasound imaging platforms, as well as collected additional safety data for AI-700 in…
- Trial name
- NCT00669851
- Testing
- AI-700
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Acusphere
Contrast-Enhanced Magnetic Resonance Imaging Detection
Pharmacokinetics, Dialysability and Safety of HRS-9231 in Healthy Volunteers and in Patients With Impaired Renal Function
This is an open-label, non-randomized, parallel cohorts design, multicenter, single dose phase I study. The primary objectives are: To evaluate the pharmacokinetics (plasma and urine) profile of HRS-9231 following single…
- Trial name
- NCT06657560
- Testing
- HRS-9231
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Shanghai Shengdi Pharmaceutical Co., Ltd
Multiple Sclerosis
Patient Centered Outcomes Analysis for MS Using a Mobile Application
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that can impact all aspects of nervous system function.
- Trial name
- NCT04281160
- Testing
- BeCare Mobile App
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BeCare Link LLC
Athletic Performance
Priming Using Contrast Training Exercise
This study investigated the effects of a morning complex-contrast training session on afternoon sport-specific and physical performance in competitive judokas.
- Trial name
- NCT07754669
- Testing
- Morning Complex-Contrast Training, Time-Matched Walking Control Condition
- Where
- Poland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice