Clinical trials: Controlled Diabetes
Diabetes, Diabetes Mellitus, Type 2
Safety and Efficacy of Insulin NPH Compared to a New Insulin Formulation in Subjects With Type 2 Diabetes
This trial is conducted in South America. This trial aims for a comparison of the safety and efficacy of insulin NPH and a new insulin formulation on blood glucose control.
- Trial name
- NCT00660374
- Testing
- insulin NPH, EX1000
- Where
- Brazil
- Volunteers
- 402 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Multiple Ascending Dose Phase I Study of DBPR108 in Healthy Male Subjects
The study is being performed to assess the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) properties of multiple oral doses of DBPR108 in healthy male subjects.
- Trial name
- NCT02163278
- Testing
- DBPR108
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Type 2 Diabetes Mellitus (DM)
Mulligan Mobilization With Movement Versus Conventional Physiotherapy on Ankle Range of Motion, Mobility, Pain, and Quality of Life in Patients With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM) is a major global health concern associated with chronic hyperglycemia, oxidative stress, and accumulation of advanced glycation end-products, which impair connective tissue function and commonly…
- Trial name
- NCT07827625
- Testing
- Experimental, Control
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Ibadat International University, Islamabad
Type 2 Diabetes
Trial for People With Established Type 2 Diabetes During Ramadan
Dual therapy with metformin and Liraglutide is more effective at helping people with established Type 2 Diabetes Mellitus (T2DM) observing Ramadan achieve a triple composite endpoint of weight reduction and/or maintenance and…
- Trial name
- T4R (NCT02292290)
- Testing
- Liraglutide, Sulfonylurea or Pioglitazone, Maintain dual therapy (Sulf/Pio) as comparator to Liraglutide
- Where
- 2 sites in United Kingdom
- Volunteers
- 99 people
- Sponsor
- University of Leicester
Diabetic Retinopathy
Using Calcium Dobesilate to Treat Chinese Patients With Mild to Moderate Non-proliferative Diabetic Retinopathy
Calcium dobesilate has been recommended to treat diabetic retinopathy due to its potential in protecting against retinal vascular damage.
- Trial name
- CALM-DR (NCT04283162)
- Testing
- Calcium Dobesilate, conventional treatment
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zhongda Hospital
Diabetes Mellitus
Efficacy and Safety of Alogliptin in Subjects With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety of alogliptin, once daily (QD), in adults with type 2 diabetes.
- Trial name
- NCT00286455
- Testing
- Alogliptin
- Where
- 67 sites in United States, Argentina and 16 more
- Volunteers
- 329 people
- Sponsor
- Takeda
Type2 Diabetes Mellitus
Multicenter Study to Evaluate the Effect of BTI320 on Glycemic Control in Type 2 Diabetes
The objective of the current study is to investigate the efficacy and safety of BTI320 compared to placebo in addition to metformin and/or sulfonylureas on glycemic control over 12 weeks in subjects with type 2 diabetes mellitus.
- Trial name
- NCT03655535
- Testing
- BTI320
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- Boston Therapeutics
Diabetes Mellitus, Type 1
Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)
The study will investigate the efficacy, safety, tolerability and Pharmacokinetic(PK) of 3 doses of empagliflozin compared with placebo over 26 weeks in 960 patients with type 1 diabetes mellitus as adjunctive therapy to insulin
- Trial name
- NCT02580591
- Testing
- Empagliflozin
- Where
- 189 sites in United States, Australia and 22 more
- Volunteers
- 977 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus
Study of Welltang- a Cell Phone-based Diabetes Management Application's Effect on Blood Glucose Control
The aim was to assess the impact of a cell phone-based diabetes management application (Welltang) on HbA1c, blood glucose, lipids, physical activity, weight, and blood pressure during 3 months.
- Trial name
- NCT02313090
- Testing
- Welltang
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabetes Mellitus (Type 2)
Empowering Veterans to Actively Communicate and Engage in Shared Decision Making in Medical Visits, A Randomized Controlled Trial
Type 2 diabetes is a significant condition in VA affecting 20% of VA patients. Adherence to medication regimens and lifestyle factors is important to achieve care goals for these patients.
- Trial name
- ACTIVet-2 (NCT05169359)
- Testing
- Speak Up! Video
- Where
- 3 sites in United States
- Volunteers
- 512 people
- Sponsor
- VA Office of Research and Development
Diabetic Foot Ulcer
Plantar Pressure Distribution in Diabetic Foot Ulcer
The goal of this clinical trial is to find out the changes in peak pressure and pressure-time integral after twelve weeks from the initial utility of foot insoles and eight weeks later as a follow-up in diabetic foot ulcers.
- Trial name
- PPDDFU (NCT05888259)
- Testing
- foot insole
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus
Follow-Up Study for Exubera
In studies of Exubera in persons with diabetes, lung cancer occurred in a few more people who were taking Exubera than in people who were taking other diabetes medicines.
- Trial name
- FUSE (NCT00734591)
- Testing
- Exubera, Randomized diabetes therapy
- Where
- 321 sites in United States, Argentina and 23 more
- Volunteers
- 7,439 people
- Sponsor
- Pfizer
Gestational Diabetes
Maternal Weight Gain in Gestational Diabetes Controlled by Metformin Versus Insulin
Insulin has many disadvantages for mothers with GDM including the need to give injections, frequent daily testing for monitoring, and risks of hypoglycemia, increase in appetite, weight gain and high cost.
- Trial name
- NCT03841591
- Testing
- Insulin, Metformin, Assessment of weight gain
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 1
Assessment of an iPhone Application on Glycemic Control in Type 1 Diabetes
The purpose of the study is to assess whether an electronic self-management tool, specifically an iPhone application entitled bant, can improve glycemic control in Adolescents who have Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT01899274
- Testing
- bant iPhone application
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- The Hospital for Sick Children
Dyslipidemia
Efficacy and Safety of Alirocumab Versus Usual Care on Top of Maximally Tolerated Statin Therapy in Patients With Type 2 Diabetes and Mixed Dyslipidemia (ODYSSEY DM-Dyslipidemia)
Primary Objective: To demonstrate the superiority of alirocumab in comparison with usual care in the reduction of non-high-density lipoprotein cholesterol (non-HDL-C) in participants with type 2 diabetes and mixed dyslipidemia at…
- Trial name
- NCT02642159
- Testing
- Alirocumab, Statins, Ezetimibe
- Where
- 119 sites in United States, Australia and 13 more
- Volunteers
- 413 people
- Sponsor
- Sanofi
Type 2 Diabetes, Obesity
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-2 (NCT05929079)
- Testing
- Retatrutide
- Where
- 98 sites in United States, Argentina and 6 more
- Volunteers
- 1,152 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus, Celiac Disease
Fiber-enriched Buckwheat Pasta and Glucose Variability in Patients With Type 1 Diabetes and Celiac Disease
The intervention was preceded by a 1-week run-in period during which participants underwent continuous glucose monitoring (CGM) and filled in a 7-day dietary record to optimize basal infusion rate and insulin-to-glycemic load…
- Trial name
- NCT03380988
- Testing
- Acute test meal with fiber-enriched buckwheat pasta, Acute test meal with corn pasta
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Diabetes Mellitus Type 2 in Obese
Early Glycaemic Control in Type 2 Diabetes Patients After Bariatric Surgery; ECODABS
Describe and characterize the time-course for improvement in glucose control after bariatric surgery in obese patients with type 2 diabetes Compare these changes in glycemic control after different techniques for bariatric surgery
- Trial name
- NCT04314427
- Testing
- Roux-en-Y gastric bypass, Sleeve gastrectomy
- Where
- 8 sites in Belgium, Spain and 2 more
- Volunteers
- 33 people
- Sponsor
- Sahlgrenska University Hospital
Diabetic Foot
Clinical Trial for the Treatment of Diabetic Foot Ulcers Using a Nitric Oxide Releasing Patch: PATHON
Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences.
- Trial name
- NCT00428727
- Testing
- Controlled nitric oxide releasing patch
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Type 2 Diabetes Mellitus
Evaluate Safety and Effectiveness of MBX-102 in Type 2 Diabetes Patients With Poor Glycemic Control on Metformin
To define the relative efficacy, safety and tolerability profiles of oral daily MBX-102 at daily doses of 400 and 600 mg vs. placebo and Actos® 30 mg (up-titrated to 45 mg after 8 weeks) when administered for up to 24 weeks in…
- Trial name
- NCT00814372
- Testing
- MBX-102, Actos, Metformin
- Where
- 26 sites in United States, India
- Volunteers
- 242 people
- Sponsor
- Gilead Sciences
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