Clinical trials: Controlled Hypertension
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension
To investigate the dose-response relationship of DE-104 ophthalmic solution in lowering intraocular pressure (IOP) in subjects with Primary Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00650338
- Testing
- DE-104 ophthalmic solution, low concentration, DE-104 ophthalmic solution, medium concentration, DE-104 ophthalmic solution, high concentration
- Where
- 14 sites in United States
- Volunteers
- 165 people
- Sponsor
- Santen Inc.
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Hypertension
A Study in the Use of Home Blood Pressure Monitoring and Telephone Follow-up to Control Blood Pressure
The purpose of this study is to determine if the use of home blood pressure monitors plus nurse telephone monitoring is more effective than the use of blood pressure monitors alone in improving control of high blood pressure in…
- Trial name
- NCT00662753
- Testing
- Home monitoring, monitor & phone call
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- George Washington University
Pre-eclampsia
Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia
This study is designed in two parts. Part 1 will assess the safety and tolerability of different doses of RLX030 when given to pregnant women with pre- eclampsia (elevated blood pressure with protein in urine).
- Trial name
- NCT01566630
- Testing
- RLX030
- Where
- 5 sites in United States, Italy
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Hypercholesterolemia, Hypertension
Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
This Phase 2 study will assess the efficacy and safety of ETC-1002 monotherapy versus placebo in participants with hypercholesterolemia and hypertension.
- Trial name
- NCT02178098
- Testing
- ETC-1002
- Where
- 43 sites in United States
- Volunteers
- 143 people
- Sponsor
- Esperion Therapeutics, Inc.
Hypertension
Effect of Rosuvastatin on Coronary Flow Reserve in Hypertensive Patients With Cardiovascular Risk
Investigators recently demonstrated that coronary flow reserve (CFR) significantly improved after rosuvastatin therapy in hypertensive patients with average levels of serum cholesterol by measuring the change in CFR after 1 year…
- Trial name
- RESERVE II (NCT02482207)
- Testing
- Rosuvastatin, Life style modification
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Asan Medical Center
Hypertension
Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel…
- Trial name
- NCT02294539
- Testing
- Losartan 50mg/amlodipine 5mg, Losartan 100mg/amlodipine 5mg, Losartan 50mg/Hydrochlorothiazide 12.5mg
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- Chong-Jin Kim
Hypertension, Diabetes
Addressing Hypertension Care in Africa
A pilot cluster randomized control trial to test the feasibility of a multilevel, nurse-led, mobile health enhanced intervention in patients with uncontrolled hypertension in Ghana
- Conditions
- Hypertension, Diabetes, Telemedicine
- Trial name
- ADHINCRA (NCT04010344)
- Testing
- Enhanced Usual Care Group, Usual Care Group
- Where
- 4 sites in Ghana
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Hypertension in Pregnancy
Effect of Hydroxytyrosol on NLR, MLR, and SOD in Hypertensive Pregnant Women
The goal of this clinical trial is to evaluate whether hydroxytyrosol supplementation (10 mg/day for 4 weeks) is effective in improving inflammatory and oxidative stress markers in pregnant women diagnosed with hypertensive…
- Trial name
- HyPreg (NCT07074548)
- Testing
- Hydroxytyrosol
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Hemolytic and uremic syndrome (HUS) is a clinic-biological syndrome related to thrombotic microangiopathy affecting predominantly the kidney.
- Trial name
- HYPERSHU (NCT05726916)
- Testing
- Soliris®, Renin angiotensin system blockers
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
Cardiovascular Diseases, Medication Adherence
Pharmacist-led Medication Review With Follow-up on Primary Care Cardiovascular Older Adult Patients.
Hypothesis: Medication Review with follow-up can improve clinical, health related quality of life and economic outcomes. To prove this hypothesis a cluster randomized controlled trial will be held in primary care centres of the…
- Conditions
- Cardiovascular Diseases, Medication Adherence, Drug Use, Hypertension
- Trial name
- POLARIS (NCT03502109)
- Testing
- Medication review with follow-up
- Where
- Chile
- Volunteers
- 340 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Primary Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.
To evaluate the safety and efficacy of PF-04217329.
- Trial name
- NCT00572455
- Testing
- PF-04217329 - Lowest Dose, PF-04217329 - Low Dose, PF-04217329 - Middle Dose
- Where
- 23 sites in United States
- Volunteers
- 318 people
- Sponsor
- Pfizer
Hypertension
A Quality Improvement Plan for Hypertension Control
The study hypothesis is that the implementation of a plan for quality improvement at the primary care health teams taking care of hypertensive patients, will increase the level of blood pressure control among those patients.
- Trial name
- INCOTECA (NCT00820183)
- Testing
- Quality Improvement plan for Hypertension Control
- Where
- Spain
- Volunteers
- 34,327 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Portopulmonary Hypertension
Revatio Portal-Pulmonary Arterial Hypertension Trial
The investigators propose the first prospective, double blind, randomized controlled trial of treatment for pulmonary arterial hypertension (PAH) related to underlying portal hypertension.
- Trial name
- RePo1 (NCT01517854)
- Testing
- Sildenafil
- Where
- 3 sites in Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Open Angle Glaucoma
A Phase 1b Study of ONL1204 Ophthalmic Solution in Patients with Progressing Open Angle Glaucoma
The purpose of this study is to demonstrate the safety and tolerability of ONL1204 Ophthalmic Solution in patients with progressing open angle glaucoma.
- Trial name
- NCT05160805
- Testing
- ONL1204 Ophthalmic solution (Dose A), ONL1204 Ophthalmic solution (Dose B)
- Where
- 11 sites in Australia, New Zealand
- Volunteers
- 25 people
- Sponsor
- ONL Therapeutics
Glaucoma Open-Angle Primary, Cataract
Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for Glaucoma Patients
Laser endoscopic cyclophotocoagulation (ECP) has been in use for the treatment of glaucoma for over 20 years and is usually used in conjunction with cataract surgery.
- Trial name
- CONCEPT (NCT04295122)
- Testing
- Phacoemulsification+ Endoscopic cyclophotocoagulation (ECP) laser
- Volunteers
- 160 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hypertension, Condition
Adaptive Cognitive Training on Cognitive Function in Elderly Hypertension Patients in the Community
Objective A growing body of evidence supports hypertension as a risk factor for cognitive decline. Hypertension is significantly associated with accelerated cognitive decline, poorer cognitive function, and mild cognitive…
- Conditions
- Hypertension, Condition, Aging
- Trial name
- NCT06512922
- Testing
- adaptive cognitive training
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Hypertension
Tailored Approaches to Improve Medication Adherence
The purpose of this study is to to culturally tailor a technology-based individualized adherence intervention for Black and Latino patients with uncontrolled HTN or T2DM, who are non-adherent to their medications, and determine…
- Trial name
- NCT01643473
- Testing
- Adherence Intervention, Attention Control
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- NYU Langone Health
Hypertension
Evaluating the Use of a Remote Telehome Monitoring Hypertension Program for Patients Receiving Virtual Care
High blood pressure or hypertension (HTN) is very common and can lead to serious health issues and even death. Medications and lifestyle changes can be used to treat HTN.
- Trial name
- HTN THM (NCT05300503)
- Testing
- Telehome Monitoring
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Heart Institute Research Corporation
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