Clinical trials: Controlled Hypertension
Essential (Primary) Hypertension
Smartphone-Guided Paced Breathing and Aerobic Exercise for Essential Hypertension
Hypertension is a major risk factor for cardiovascular disease and is associated with reduced functional capacity and impaired quality of life.
- Trial name
- SPB-HTN (NCT07717996)
- Testing
- Smartphone-Guided Paced Breathing, Aerobic Exercise, Smartphone-Guided Paced Breathing + Aerobic Exercise
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Chronic Kidney Diseases
Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)
This Phase 3, randomized, Double-blind, placebo-controlled, 2-arm, parallel-group, multicenter study with randomized withdrawal will evaluate the efficacy, safety, and durability of KBP-5074 in adult participants who have stage…
- Trial name
- Clarion-CKD (NCT04968184)
- Testing
- KBP-5074
- Where
- 215 sites in United States, Australia and 20 more
- Volunteers
- 666 people
- Sponsor
- Novo Nordisk A/S
Portal Hypertension, Cirrhosis, Liver
The vPPG-detecting Software Guided Management of Cirrhotic Portal Hypertension
The aim of this study is to investigate the possibilities and effectiveness of managing cirrhotic portal hypertension using the non-invasive portal pressure gradient (PPG) detecting software.
- Trial name
- NCT04786782
- Testing
- PPG-detecting software, LSM and PLT count
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Changqing Yang
Heart Failure With Preserved Ejection Fraction, Pulmonary Hypertension
Study of HS135 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
A Study of HS135 for the Treatment of in Obese Patients with Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
- Trial name
- NCT06581159
- Testing
- HS135
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- 35Pharma Inc., a GSK company
Pseudotumor Cerebri, Cystinosis
The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study
This study will examine whether the tendency to have thrombosis, or the formation of blood clots inside blood vessels, has a role in the development of pseudotumor cerebri (PTC).
- Trial name
- NCT00071903
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Primary Open-angle Glaucoma
Multicenter Study Using Glaukos® Trabecular Micro-Bypass Stent Model GTS400 Using the G2-M-IS Injector System in Conjunction With Cataract Surgery
Evaluate the safety and efficacy of the Glaukos Trabecular Micro-Bypass Stent Model GTS400 using the G2-M-IS injector system in conjunction with cataract surgery vs.
- Trial name
- NCT01461291
- Testing
- iStent inject, Cataract surgery
- Where
- United States
- Volunteers
- 505 people
- Sponsor
- Glaukos Corporation
Hypertension, Hyperaldosteronaemia
Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia
Elevated aldosterone causes moderate to severe increase in blood pressure, and leads to various target organ damage including cardiovascular ones.
- Trial name
- EMRACHH (NCT05688579)
- Testing
- Mineralocorticoid Receptor Antagonists(MRAs), Blank control
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Nanfang Li
Essential Hypertension, Atrial Fibrillation
Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension
The purpose of this 7- to 13-month study is to determine the efficacy of 8 mg/day oral perindopril to prevent the recurrence of atrial fibrillation (AF) in patients with essential hypertension.
- Trial name
- CTAF-2 (NCT00461903)
- Testing
- Perindopril
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- Montreal Heart Institute
Open Angle Glaucoma
Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma
The purpose of this study is to compare the efficacy and safety of Trabectome versus Trabeculectomy with adjunctive Mitomycin C, combined with cataract surgery, in patients with open angle glaucoma.
- Trial name
- NCT00901108
- Testing
- Trabectome-IOL, Trab-IOL
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Alberta
Glaucoma, Ocular Hypertension
Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension
This purpose of this study is to access the efficacy, tolerability and safety of RKI983 (0.05% and 0.10%) ophthalmic solution bid versus once daily latanoprost 0.005%, in patients with POAG or ocular hypertension.
- Trial name
- NCT00846989
- Testing
- RKI983A, Latanoprost
- Where
- 29 sites in United States
- Volunteers
- 276 people
- Sponsor
- Novartis Pharmaceuticals
Liver Cirrhosis
Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study)
This is a two part Phase IIa/b multicentre, randomised, double-blind, placebo-controlled, parallel group dose-ranging study to assess the efficacy, safety, and tolerability of the combination of zibotentan and dapagliflozin, and…
- Trial name
- ZEAL (NCT05516498)
- Testing
- Part A: zibotentan (dose B) + dapagliflozin, Part B: zibotentan (dose A) + dapagliflozin
- Where
- 50 sites in United States, Australia and 13 more
- Volunteers
- 205 people
- Sponsor
- AstraZeneca
Hypertension
Individually Tailored Web-Based Program to Improve Blood Pressure Control
High blood pressure affects 65 million adults in the United States, and more than one third of these individuals do not have adequate control of their blood pressure.
- Trial name
- NCT00377208
- Testing
- Web-Based Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Primary Open-Angle Glaucoma, Ocular Hypertension
Bimatoprost Ocular Insert Compared to Topical Timolol Solution in Patients With Glaucoma or Ocular Hypertension
The objective of this Phase 2 study is to evaluate whether the Bimatoprost Ocular Insert is non-inferior to that of timolol ophthalmic solution (0.5%) at 12 weeks.
- Trial name
- NCT01915940
- Testing
- Bimatoprost, Timolol 0.5%
- Where
- 10 sites in United States
- Volunteers
- 169 people
- Sponsor
- ForSight Vision5, Inc.
Cardiovascular Diseases, Heart Diseases
IN CONTROL--Hypertension Reduction in Inner City Seattle
To implement and evaluate with a randomized, controlled trial interventions to improve control of hypertension among inner city low- income and minority residents of Seattle.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005698
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prehypertension, Prehypertension (Elevated Blood Pressure) or Hypertension
Effects of the DASH Diet and Lifestyle Modification on Blood Pressure in Adults With Prehypertension
This pilot randomized controlled trial evaluated the effects of the Dietary Approaches to Stop Hypertension (DASH) diet and lifestyle modification on blood pressure in adults with prehypertension.
- Trial name
- DASH-PREHT (NCT07692971)
- Testing
- Lifestyle Modification Advice, DASH Diet
- Volunteers
- 32 people
- Sponsor
- Antalya Bilim University
Hypertension, Tachycardia
Comparison of Fentanyl and Magnesium to Control Reflex Hemodynamics in Patients Aged 50 and Older
This prospective, randomized, controlled trial aims to evaluate the effects of magnesium sulfate and fentanyl on the hemodynamic response to endotracheal intubation in surgical patients aged 50 years and older.
- Trial name
- NCT07258628
- Testing
- magnesium sulfate, Fentanyl (IV)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara City Hospital Bilkent
Hypertension
Improving Blood Pressure Control Among Food Insecure Hypertensive Adults
The overall objective of this project is to assess the feasibility, acceptability, and appropriateness of adapted community health worker (CHW)-led implementation strategies designed to improve intake of fruits and vegetables and…
- Trial name
- NCT05877898
- Testing
- CHW Education, CHW Education and Navigation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Florida
Blood Pressure, High
Goal Setting and Mobile-based Self-management Tool to Improve Diet Quality of People With High Blood Pressure
SMART goal setting is a patient-led method that can help improve execution and facilitate behavioral changes. Functions such as diet tracking, interaction, and feedback in smartphone application may help enhance patient…
- Trial name
- NCT06988501
- Testing
- Goal setting with mobile-based self-management tool, Nutrition education
- Where
- China
- Volunteers
- 110 people
- Sponsor
- China National Center for Cardiovascular Diseases
Persistent Pulmonary Hypertension of the Newborn
Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children
Neonates with persistent pulmonary hypertension (PPH) should be administered inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO), but these are not available in most resource-constrained settings like ours.
- Trial name
- NCT06562036
- Testing
- Sildenafil, Milrinone
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Muhammad Aamir Latif
Hypertension in Type 2 Diabetes
Device-guided Breathing Exercises on Blood Pressure in Diabetic Patients
Rationale: Hypertension is an important risk factor of cardiovascular disease, especially in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- Reperate3 (NCT00951119)
- Testing
- Resperate
- Where
- 2 sites in Netherlands
- Volunteers
- 48 people
- Sponsor
- Medical Research Foundation, The Netherlands
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